2023
DOI: 10.1167/iovs.64.15.9
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Tear Fluid Inflammatory Proteome Analysis Highlights Similarities Between Keratoconus and Allergic Conjunctivitis

Marlies Gijs,
Tuneille I. Adelaar,
Daphne P. C. Vergouwen
et al.

Abstract: Purpose Keratoconus is characterized by the progressive thinning of the cornea, which leads to a cone-like appearance of the eye over time. Although conventionally defined as a noninflammatory condition, a number of recent studies have associated keratoconus (KC) with allergic conjunctivitis (AC) based on clinical parameters. This study aimed to consolidate this association by performing a proteomic analysis of tear fluid from patients with keratoconus and/or allergic conjunctivitis. … Show more

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Cited by 2 publications
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“…Ruedemann also reported a history of allergic reactions in most patients with keratoconus ( Ruedemann, 1970 ; Wajnsztajn and Solomon, 2021 ; Seth et al, 2023 ). There are some similarities between keratoconus and allergic conjunctivitis ( Gijs et al, 2023 ). Allergic reactions cause inflammation, and our study of an association between IBD and keratoconus also provides some evidence for the theory of allergic reaction in keratoconus.…”
Section: Discussionmentioning
confidence: 99%
“…Ruedemann also reported a history of allergic reactions in most patients with keratoconus ( Ruedemann, 1970 ; Wajnsztajn and Solomon, 2021 ; Seth et al, 2023 ). There are some similarities between keratoconus and allergic conjunctivitis ( Gijs et al, 2023 ). Allergic reactions cause inflammation, and our study of an association between IBD and keratoconus also provides some evidence for the theory of allergic reaction in keratoconus.…”
Section: Discussionmentioning
confidence: 99%