Technetium‐99m ECD Single Photon Emission Computed Tomography in Brain Trauma: Comparison of Early Scintigraphic Findings With Long‐Term Neuropsychological Outcome

Baulieu, F.; Fournier, Patrice; Baulieu, Jean-Louis; Dalonneau, Marinette; Chiaroni, Patrick; Eder, Véronique; Pottier, Jean Marie; Legros, Bernard

doi:10.1111/j.1552-6569.2001.tb00020.x

Cited by 16 publications

(11 citation statements)

References 18 publications

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“…Abnormal SPECT can be predictive of neuropsychological deficits. 126 Studies have found that decreased blood flow to various parts of the brain correlate with various types of behavior: the frontal lobes with disinhibitive behavior, the left cerebral hemisphere with increased social isolation, and the right hemispheric areas with increased aggressive behavior. 127 Deficits in frontal lobe and thalamic perfusion have been linked to impairments in executive functioning.…”

Section: Prognosis and Spectmentioning

confidence: 99%

Neuroimaging in traumatic brain imaging

2005

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Summary: Traumatic brain injury (TBI) is a common and potentially devastating clinical problem. Because prompt proper management of TBI sequelae can significantly alter the clinical course especially within 48 h of the injury, neuroimaging techniques have become an important part of the diagnostic work up of such patients. In the acute setting, these imaging studies can determine the presence and extent of injury and guide surgical planning and minimally invasive interventions. Neuroimaging also can be important in the chronic therapy of TBI, identifying chronic sequelae, determining prognosis, and guiding rehabilitation.

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Section: Prognosis and Spectmentioning

confidence: 99%

Neuroimaging in traumatic brain imaging

2005

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“…Early studies suggested that SPECT scans may aid in understanding a TBI patient’s symptomatology [21], [22]. More recently, some investigators have suggested that SPECT imaging could even assist clinicians in developing treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Clinical Comparison of 99mTc Exametazime and 123I Ioflupane SPECT in Patients with Chronic Mild Traumatic Brain Injury

et al. 2014

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BackgroundThis study evaluated the clinical interpretations of single photon emission computed tomography (SPECT) using a cerebral blood flow and a dopamine transporter tracer in patients with chronic mild traumatic brain injury (TBI). The goal was to determine how these two different scan might be used and compared to each other in this patient population.Methods and FindingsTwenty-five patients with persistent symptoms after a mild TBI underwent SPECT with both 99mTc exametazime to measure cerebral blood flow (CBF) and 123I ioflupane to measure dopamine transporter (DAT) binding. The scans were interpreted by two expert readers blinded to any case information and were assessed for abnormal findings in comparison to 10 controls for each type of scan. Qualitative CBF scores for each cortical and subcortical region along with DAT binding scores for the striatum were compared to each other across subjects and to controls. In addition, symptoms were compared to brain scan findings. TBI patients had an average of 6 brain regions with abnormal perfusion compared to controls who had an average of 2 abnormal regions (p<0.001). Patient with headaches had lower CBF in the right frontal lobe, and higher CBF in the left parietal lobe compared to patients without headaches. Lower CBF in the right temporal lobe correlated with poorer reported physical health. Higher DAT binding was associated with more depressive symptoms and overall poorer reported mental health. There was no clear association between CBF and DAT binding in these patients.ConclusionsOverall, both scans detected abnormalities in brain function, but appear to reflect different types of physiological processes associated with chronic mild TBI symptoms. Both types of scans might have distinct uses in the evaluation of chronic TBI patients depending on the clinical scenario.

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“…These perfusion deficits may extend into normal appearing tissue, and in some cases, very diffuse hemodynamic abnormalities consistent with the concept of diaschisis have been reported. 2,17,18 Overall, resting PET and SPECT demonstrate abnormalities in 25% to 80% of head trauma survivors-the likelihood of a positive finding being dependent on the severity of initial trauma, the presence of MRI findings, the severity of postconcussive compromise, and the time lag between imaging and the traumatic event. 14 SPECT studies in mild trauma often show focal regions of hypoperfusion consistent with expectations based on neuropsychological testing, 15,16 but not all groups have reported a strong correlation between specific regional SPECT findings and specific cognitive test results.…”

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confidence: 99%