Technetium-99m labeled Mebendazole and biodistribution in experimentally Trichinella spiralis-infected rats

İnceboz, Tonay; Yurt, Fatma; Yılmaz, Osman; Kaya, Gamze Çapa; Kolatan, Efsun; Durkan, K.; Bağriyanik, H. Alper; Üner, Ahmet

doi:10.1007/s00044-011-9590-8

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…In fact, in the study performed by Inceboz et al [120], the authors wanted to investigate the biodistribution of 99m Tc-mebendazole in a rat model, infected with T. spiralis , a nematode that is often present in wild carnivorous animals. Briefly, 750–1000 larvae were orally administrated in rats to induce infection in the muscles, while healthy rats were used as controls.…”

Section: Othersmentioning

confidence: 99%

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Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review

Auletta

Galli

Lauri

et al. 2016

Clin Transl Imaging

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Bacterial infections are still one of the main causes of patient morbidity and mortality worldwide. Nowadays, many imaging techniques, like computed tomography or magnetic resonance imaging, are used to identify inflammatory processes, but, although they recognize anatomical modifications, they cannot easily distinguish bacterial infective foci from non bacterial infections. In nuclear medicine, many efforts have been made to develop specific radiopharmaceuticals to discriminate infection from sterile inflammation. Several compounds (antimicrobial peptides, leukocytes, cytokines, antibiotics…) have been radiolabelled and tested in vitro and in vivo, but none proved to be highly specific for bacteria. Indeed factors, including the number and strain of bacteria, the infection site, and the host condition may affect the specificity of tested radiopharmaceuticals. Ciprofloxacin has been proposed and intensively studied because of its easy radiolabelling method, broad spectrum, and low cost, but at the same time it presents some problems such as low stability or the risk of antibiotic resistance. Therefore, in the present review studies with ciprofloxacin and other radiolabelled antibiotics as possible substitutes of ciprofloxacin are reported. Among them we can distinguish different classes, such as cephalosporins, fluoroquinolones, inhibitors of nucleic acid synthesis, inhibitors of bacterial cell wall synthesis and inhibitors of protein synthesis; then also others, like siderophores or maltodextrin-based probes, have been discussed as bacterial infection imaging agents. A systematic analysis was performed to report the main characteristics and differences of each antibiotic to provide an overview about the state of the art of imaging infection with radiolabelled antibiotics.

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Section: Othersmentioning

confidence: 99%

“…a.90 % at 2 hRatLungs 99m Tc-mebendazoleT. Inceboz [120]Direct labelling—SnCl 2 ·2H 2 O2.3–4.6 × 10 −2 n. a.n.…”

Section: Summary Of Systematic Analysis Of the Literaturementioning

confidence: 99%

Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review

Auletta

Galli

Lauri

et al. 2016

Clin Transl Imaging

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Currently Available Radiopharmaceuticals for Imaging Infection and the Holy Grail

Salmanoglu

Kim

Thakur

2018

Seminars in Nuclear Medicine

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Infection is ubiquitous. However, its management is challenging for both the patients and the health-care providers. Scintigraphic imaging of infection dates back nearly half a century. The advances in our understanding of the pathophysiology of disease at cellular and molecular levels have paved the way to the development of a large number of radiopharmaceuticals for scintigraphic imaging of infection. These include radiolabeling of blood elements such as serum proteins, white blood cells (WBCs), and cytokines, to name a few. Infectious foci have also been imaged using a radiolabeled sugar molecule by taking advantage of increased metabolic activity in the infectious lesions. Literature over the years has well documented that none of the radiopharmaceuticals and associated procedures that facilitate imaging infection are flawless and acceptable without a compromise. As a result, only a few compounds such as Tc-hexamethylpropyleneamineoxime,F-FDG, the oldest but still considered as a gold standard In-oxine, and, yes, evenGa-citrate in some countries, have remained in routine clinical practice. Nonetheless, the interest of scientists and physicians to improve the approaches to imaging and to the management of infection is noteworthy. These approaches have paved the way for the development of numerous, innovative radiopharmaceuticals to label autologous WBCs ex vivo or even those that could be injected directly to image infection or inflammation without direct involvement of WBCs. In this review, we briefly describe these agents with their pros and cons and place them together for future reference.

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^99mTc‐labeled antibiotics for infection diagnosis: Mechanism, action, and progress

Naqvi

2021

Chem Biol Drug Des

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Discovery of penicillin marked a turning point in the history of infection therapy which also led to the emergence of bacterial resistance. It is now 100 years to fight with ever‐muted variants of pathogens by developing more and more antibiotics. Since 1987 to todate, no successful class of antibiotic was introduced; this three decade period is known as “the discovery void” period. While, the clinically approved antibiotics are gradually dying in front of bacterial resistance due to which bacterial infections are appearing leading cause of death and disability. Nuclear medicine imaging technique is the strongest modality to diagnose and follow‐up of deep‐seated and complicated infections. However, the selection of radiolabeled antimicrobial agents plays critical role in gaining sensitivity and specificity of the imaging results. This review comprises of two main sections; first section explains antibiotic targets, and second section explains the imaging efficacy of 99mTc‐labeled antimicrobial agents against bacterial infection along with the emphasis on progress and update of 99mTc‐labeled antibiotics as infection imaging probes. The review, in conclusion, could be an acceleration for radiopharmaceutical chemists for designing and developing 99mTc‐labeled antimicrobial agents to improve infection imaging quality.

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Technetium-99m labeled Mebendazole and biodistribution in experimentally Trichinella spiralis-infected rats

Cited by 6 publications

References 29 publications

Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review

Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review

Currently Available Radiopharmaceuticals for Imaging Infection and the Holy Grail

^99mTc‐labeled antibiotics for infection diagnosis: Mechanism, action, and progress

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