Technetium-99m Phosphate Bone Imaging: A Method for Assessing Bone Graft Healing

Stevenson, John S.; Bright, Robert W.; Dunson, George L.; Nelson, Fred R.T.

doi:10.1148/110.2.391

Cited by 68 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bone scintigraphy using 99mTc-bisphosphonate compounds has also been used for the evaluation of vascularization of bone grafts. 30 The most important concern is whether the radiologic findings correctly reflect the histologic reparative process or not. Increased uptake on scintigraphy was considered to reflect good remodeling of grafted bone.…”

Section: Discussionmentioning

confidence: 99%

Vascularized Fibular Flaps Enhance Histological Repair in Pasteurized Autogenous Bone Graft

Nishida

Tsukushi²,

Wasa³

et al. 2011

Annals of Plastic Surgery

View full text Add to dashboard Cite

The healing process of structural pasteurized autogenous bone graft has not been studied in detail. The purpose of this investigation was to assess the reparative process of pasteurized bone graft histologically, and clarify the factors influencing the outcome. From among 51 cases using pasteurized autogenous bone graft since 1992, 10 specimens were retrieved after lower extremity reconstruction of tibia or femur with or without simultaneous fibula flap, and subjected to the analysis. Regeneration of the grafted bone was assessed as the ratio of the number of viable cells to that of whole cells. Pasteurized bone combined with a vascularized fibula showed markedly better repair. Long duration from implantation to retrieval was associated with a better reparative process with vascularized fibula (P = 0.03), whereas other factors had no significant impact. This study demonstrated that pasteurized autogenous bone graft remained structurally stable for many years, although facilitators such as the combined use of a vascularized fibula are required to promote regeneration of the graft.

show abstract

Section: Discussionmentioning

confidence: 99%

Vascularized Fibular Flaps Enhance Histological Repair in Pasteurized Autogenous Bone Graft

Nishida

Tsukushi²,

Wasa³

et al. 2011

Annals of Plastic Surgery

View full text Add to dashboard Cite

show abstract

“…This imaging modality has been used to assess spinal fusions; 21 however, clinical studies have not shown this test to be reliable in detecting pseudarthrosis that is otherwise documented surgically. 8 Magnetic resonance imaging has also been used to evaluate spinal fusions.…”

Section: Technetium Bone Scanning and Mr Imagingmentioning

confidence: 99%

Surgical Interbody Research Group–radiographic assessment of interbody fusion devices: fusion criteria for anterior lumbar interbody surgery

Burkus¹,

Foley²,

Haid³

et al. 2001

FOC

119

View full text Add to dashboard Cite

The authors present their radiographic criteria for assessing fusion of the lumbar spine after anterior interbody fusion with intradiscal implants. These criteria include the assessment of plain radiographs, dynamic motion radiographs, and thin-cut computerized tomography scans. Fusion within the instrumented spinal motion segment can be determined using radiographic evaluation to assess spinal alignment on sequential examinations, angular and translational changes on dynamic motion studies, and device–host interface, and to identify new bone formation and bone remodeling. Finally, to aid the clinician in assessing fusion, the authors describe the five zones of fusion within the intervertebral disc space.

show abstract

“…adequate localised perfusion, and vitality of the muscle cells and osteoblasts are essential for an adequate healing process. These well-known components are demonstrated on three-phase bone scintigraphy, and it is known that complications in cortical and cancellous bone graft incorporation or non-viability of the graft can be recognised by bone scintigraphy [18,19,20,21,22,23,24,25,26].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of 99mTc-tetrofosmin scintigraphy in maxillofacial flaps

Aigner

Schultes

Sorantin

2003

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

In oro-maxillofacial malignancies, new therapeutic approaches are placing changing demands on the diverse diagnostic modalities. In contradistinction to mandibular reconstruction of former years, the transplants (microvascular anastomosed pedicled flaps, "flaps") now consist of one or more arteries feeding a soft tissue component attached to a piece of bone suitably fitted to fill the defect. We addressed the diagnostic value of technetium-99m tetrofosmin scintigraphy in differentiating between viability and non-viability of the soft tissue portion of flaps in the immediate postoperative assessment. A total of 60 patients who had received flaps for reconstruction of the mandible after partial resection were investigated with (99m)Tc-tetrofosmin 3-5 days after surgery. Scintigraphy consisted of (a) radionuclide angiography, (b) static planar imaging in four projections starting at 10 min post injection, and (c) single-photon emission tomography (SPET) performed immediately after the planar imaging. Normal perfusion associated with no defects throughout the soft tissue portion of the transplant was observed in 46/60 patients. This scintigraphic pattern was identical to viability and normal postoperative follow-up. Hypoperfusion and small defects on planar and SPET images indicated viability and uncomplicated postoperative healing in 6/60 patients, but non-viability/inadequate healing of the flap in 4/60 patients. Absence of perfusion combined with a large defect on static planar and SPET images definitively showed the non-viability of the flap (4/60 patients). It is concluded that (99m)Tc-tetrofosmin scintigraphy is a sensitive diagnostic tool for the immediate postoperative assessment of the viability and the adequacy of implantation of the soft tissue portion of flaps. Therefore tetrofosmin scintigraphy is an important modality in order (a) to define the optimal therapeutic regimen in the immediate postoperative period and (b) to provide better prognosis.

show abstract

Technetium-99m Phosphate Bone Imaging: A Method for Assessing Bone Graft Healing

Cited by 68 publications

References 0 publications

Vascularized Fibular Flaps Enhance Histological Repair in Pasteurized Autogenous Bone Graft

Vascularized Fibular Flaps Enhance Histological Repair in Pasteurized Autogenous Bone Graft

Surgical Interbody Research Group–radiographic assessment of interbody fusion devices: fusion criteria for anterior lumbar interbody surgery

Diagnostic and prognostic value of 99mTc-tetrofosmin scintigraphy in maxillofacial flaps

Contact Info

Product

Resources

About