Technical aspects and challenges of colorimetric detection with microfluidic paper-based analytical devices (μPADs) - A review

Morbioli, Giorgio Gianini; Mazzu-Nascimento, Thiago; Stockton, Amanda M.; Carrilho, Emanuel

doi:10.1016/j.aca.2017.03.037

Cited by 352 publications

(162 citation statements)

References 116 publications

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“…Three distinguished branches with hydrophobic barriers made of SU-8 photoresist were patterned on chromatography paper using photolithography process and used for glucose and albumin detection. Since the development of 2D-l PAD, extensive research has been carried out in device design, performance improvement and their utilization in various point-of-care applications in the past decades (Cate et al 2014;Kumar et al 2016aKumar et al , b, 2017aKumar et al , b, 2018Morbioli et al 2017;Li et al 2017;You et al 2017;Yeh et al 2017;Whitesides 2018).…”

Section: Paper Microfluidics: Historical Perspectivementioning

confidence: 99%

A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics

Kumar

Bhushan

Ágarwal

et al. 2019

Advanced Functional Materials and Sensors

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Paper-based microfluidic systems have emerged as one of the most favorable technologies used in many potential applications such as point-of-care diagnostics, flexible electronics, energy storage, etc. From the past several decades, paper-based technology has readily accepted in the academic research lab and industries as well. The paper-based devices have changed the life of humankind. The distinguishing characteristics of paper substrate like low cost, biodegradability, biocompatibility, and ease of fabrication helped their adaptability in biosensing applications. This chapter gives a concise overview of the historical perspective of paper-based devices, classification of paper types, and their recent applications.

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Section: Paper Microfluidics: Historical Perspectivementioning

confidence: 99%

A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics

Kumar

Bhushan

Ágarwal

et al. 2019

Advanced Functional Materials and Sensors

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“…The mathematical conversion of RGB intensities into the corresponding parameters of other colour spaces is well documented; [27][28][29][30] A brief introduction to the aforementioned colour spaces and their inter-conversions is given in the ESI. † However, some programs perform these conversions at a click of a button.…”

Section: -29mentioning

confidence: 99%

The Yxy colour space parameters as novel signalling tools for digital imaging sensors in the analytical laboratory

2018

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Digital imaging devices can be promising, sensitive, and cost-effective chemical sensors for resourcelimited settings. Three model colour reactions of iron were used and monitored using a simple platform consisting only of a camera, a cuvette, and a white paper diffuser. A desktop scanner and a mobile phone camera were also used as imaging devices. Captured images were analysed to obtain the RGB intensities (red, green, blue) and were further converted into the corresponding signals of the grayscale,

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“…6 Various analytical methods have been employed when utilizing PADs, including immunoassays such as colorimetric, localized surface plasmon resonance, fluorescent, electrochemical, chemiluminescent and photoelectrochemical. With the advancement of technology, the detection methods used in PAD devices have moved from the more traditional colorimetric-based detection, which is capable of generating clear, qualitative and semi-quantitative results with detection performed with the naked eye or fully quantitative with the aid of a simple spectrophotometer, [7][8][9] to the more sensitive electrochemical techniques, which utilize carbon paste or metal micro-wires electrodes as sensors to produce highly quantitative results. 10 Electrochemical techniques are being increasingly used in the fabrication and design of PADs due to the potential for miniaturization, low sensor fabrication cost, compatibility with advanced microfabrication technology and high sensitivity that is made possible by better conductivity.…”

Section: Introductionmentioning

confidence: 99%

Trends in Paper-based Electrochemical Biosensors: From Design to Application

et al. 2018

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Electrochemical bio-sensing using paper-based detection systems is the main focus of this review. The different existing designs of 2-dimensional and 3-dimensional sensors, and fabrication techniques are discussed. This review highlights the effect of adopting different sensor designs, distinct fabrication techniques, as well as different modification methods, in order to produce reliable and reproducible reading. The use of various nanomaterials have been demonstrated in order to modify the surface of electrodes during fabrication to further enhance the signal for subsequent analysis. The reviewed sensors were classified into categories based on their applications, such as diagnostics, environmental and food testing. One of the major advantages of using paper-based electrochemical sensors is the potential for miniaturization, which only requires relatively small amount of samples, and the low cost for the purpose of mass production. Additionally, most of the devices reviewed were made to be portable, making them well-suited for on-site detection. Finally, paper-based detection is an ideal platform to fabricate cost-effective, user-friendly and sensitive electrochemical biosensors, with large capacity for customization depending on functional needs.

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Technical aspects and challenges of colorimetric detection with microfluidic paper-based analytical devices (μPADs) - A review

Cited by 352 publications

References 116 publications

A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics

A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics

The Yxy colour space parameters as novel signalling tools for digital imaging sensors in the analytical laboratory

Trends in Paper-based Electrochemical Biosensors: From Design to Application

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