Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA

Mendichovszky, Iosif; Pullens, Pim; Dekkers, Ilona A.; Nery, Fábio; Bane, Octavia; Pohlmann, Andreas; Boer, A de; Ljimani, Alexandra; Odudu, Aghogho; Buchanan, Charlotte; Sharma, Kanishka; Laustsen, Christoffer; Harteveld, Anita A.; Golay, Xavier; Pedrosa, Iván; Alsop, David C.; Fain, Sean B.; Caroli, Anna; Prasad, Pottumarthi V.; Francis, Susan T.; Sigmund, Eric E.; Fernández‐Seara, María A.; Sourbron, Steven

doi:10.1007/s10334-019-00784-w

Cited by 51 publications

(68 citation statements)

References 46 publications

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“…al. [32]. An in-person meeting in Prague preceded the formal start of the Delphi process allowing for attending panel members to start discussions and agree upon the method for generating recommendations [33].…”

Section: Description Of Survey Processmentioning

confidence: 99%

“…An in-person meeting in Prague preceded the formal start of the Delphi process allowing for attending panel members to start discussions and agree upon the method for generating recommendations [33]. The approach used for driving the consensus formation process included one initial preliminary survey and two "consensus" surveys [32,34]. All surveys included questions focusing on obtaining technical recommendations to facilitate translation of renal ASL to the clinic and were divided into several categories: Patient preparation, Hardware, Labelling strategy, FAIR labelling parameters, PCASL parameters, Readout, Other sequence details, Data preprocessing and Quantification.…”

Section: Description Of Survey Processmentioning

confidence: 99%

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Consensus-based technical recommendations for clinical translation of renal ASL MRI

Nery

Buchanan

Harteveld

et al. 2019

Magn Reson Mater Phy

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154

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Objectives This study aimed at developing technical recommendations for the acquisition, processing and analysis of renal ASL data in the human kidney at 1.5 T and 3 T field strengths that can promote standardization of renal perfusion measurements and facilitate the comparability of results across scanners and in multi-centre clinical studies. Methods An international panel of 23 renal ASL experts followed a modified Delphi process, including on-line surveys and two in-person meetings, to formulate a series of consensus statements regarding patient preparation, hardware, acquisition protocol, analysis steps and data reporting. Results Fifty-nine statements achieved consensus, while agreement could not be reached on two statements related to patient preparation. As a default protocol, the panel recommends pseudo-continuous (PCASL) or flow-sensitive alternating inversion recovery (FAIR) labelling with a single-slice spin-echo EPI readout with background suppression and a simple but robust quantification model. Discussion This approach is considered robust and reproducible and can provide renal perfusion images of adequate quality and SNR for most applications. If extended kidney coverage is desirable, a 2D multislice readout is recommended. These recommendations are based on current available evidence and expert opinion. Nonetheless they are expected to be updated as more data become available, since the renal ASL literature is rapidly expanding.

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Section: Description Of Survey Processmentioning

confidence: 99%

Section: Description Of Survey Processmentioning

confidence: 99%

Consensus-based technical recommendations for clinical translation of renal ASL MRI

Nery

Buchanan

Harteveld

et al. 2019

Magn Reson Mater Phy

Self Cite

154

View full text Add to dashboard Cite

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“…The consensus project consisted of an approximation of a twostep modified Delphi method [36], which is a recommended approach to determine a reliable consensus in practice guidelines on health-care-related issues. This is outlined in more detail in the covering paper [5]. The Delphi method is an iterative process using repeated survey rounds to define consensus on proposed items and effective for determining expert group consensus on topics where there is little or no definitive evidence and where opinion is important [37].…”

Section: Description Of Survey Processmentioning

confidence: 99%

“…In line with these aims, the COST Action PARENCHIMA has initiated a consensus project to define expert-based technical recommendations to harmonize imaging protocols and image analysis. This PARENCHIMA consensus project aimed to develop and apply a process for generating technical recommendations on renal MRI using Arterial Spin Labelling (ASL), Diffusion Weighted Imaging (DWI), Blood Oxygenation Level Dependent (BOLD), and T1 and T2 mapping, with a common seven-stage process was defined for attaining consensus across each, as outlined in a covering paper [5]. The technical recommendations outlined in this paper are intended to provide guidance on the current consensus of set-up of imaging protocols for researchers who are new to the field of renal T1 and T2 mapping or researchers who are interested in combining T1 and T2 mapping within a multi-parametric renal MRI protocol.…”

Section: Introductionmentioning

confidence: 99%

Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Dekkers

Boer

Sharma

et al. 2019

Magn Reson Mater Phy

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To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) and transverse (T2) relaxation time mapping. A multidisciplinary panel consisting of 18 experts in the field of renal T1 and T2 mapping participated in a consensus project, which was initiated by the European Cooperation in Science and Technology Action PARENCHIMA CA16103. Consensus recommendations were formulated using a two-step modified Delphi method. The first survey consisted of 56 items on T1 mapping, of which 4 reached the pre-defined consensus threshold of 75% or higher. The second survey was expanded to include both T1 and T2 mapping, and consisted of 54 items of which 32 reached consensus. Recommendations based were formulated on hardware, patient preparation, acquisition, analysis and reporting. Consensus-based technical recommendations for renal T1 and T2 mapping were formulated. However, there was considerable lack of consensus for renal T1 and particularly renal T2 mapping, to some extent surprising considering the long history of relaxometry in MRI, highlighting key knowledge gaps that require further work. This paper should be regarded as a first step in a long-term evidence-based iterative process towards ever increasing harmonization of scan protocols across sites, to ultimately facilitate clinical implementation.

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“…It is to be expected that renal vasomotion, at least of cortical vessels, results in renal BVf changes that exceed those documented for other tissues. 10,21,32,35 Substantial changes in the renal BVf were observed for various experimental settings. 7,11,20 Moreover, the tubules are a unique feature of the kidney.…”

Section: Upon Interventions and Their Impact On T 2 *mentioning

confidence: 97%

Probing renal blood volume with magnetic resonance imaging

et al. 2020

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Damage to the kidney substantially reduces life expectancy. Renal tissue hypoperfusion and hypoxia are key elements in the pathophysiology of acute kidney injury and its progression to chronic kidney disease. In vivo assessment of renal haemodynamics and tissue oxygenation remains a challenge. Blood oxygenation level–dependent (BOLD) magnetic resonance imaging (MRI) is sensitive to changes in the effective transversal relaxation time (T2*) in vivo, and is non‐invasive and indicative of renal tissue oxygenation. However, the renal T2* to tissue pO2 relationship is not governed exclusively by renal blood oxygenation, but is affected by physiological confounders with alterations in renal blood volume fraction (BVf) being of particular relevance. To decipher this interference probing renal BVf is essential for the pursuit of renal MR oximetry. Superparamagnetic iron oxide nanoparticle (USPIO) preparations can be used as MRI visible blood pool markers for detailing alterations in BVf. This review promotes the opportunities of MRI‐based assessment of renal BVf. Following an outline on the specifics of renal oxygenation and perfusion, changes in renal BVf upon interventions and their potential impact on renal T2* are discussed. We also describe the basic principles of renal BVf assessment using ferumoxytol‐enhanced MRI in the equilibrium concentration regimen. We demonstrate that ferumoxytol does not alter control of renal haemodynamics and oxygenation. Preclinical applications of ferumoxytol enhanced renal MRI as well as considerations for its clinical implementation for examining renal BVf changes are provided alongside practical considerations. Finally, we explore the future directions of MRI‐based assessment of renal BVf.

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Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA

Cited by 51 publications

References 46 publications

Consensus-based technical recommendations for clinical translation of renal ASL MRI

Consensus-based technical recommendations for clinical translation of renal ASL MRI

Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Probing renal blood volume with magnetic resonance imaging

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