Techniques for Drug Delivery in Psittacine Birds

Powers, Lauren V.

doi:10.1053/j.jepm.2006.06.005

Cited by 11 publications

(11 citation statements)

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“…Drugs can be administered either individually or as flock therapy in birds, and the most preferred methods of drug administration are drinking water and feed medication (Vermeulen et al, 2002). However, these methods also have certain disadvantages such as differences in drug intake among animals, changing water and feed intake according to disease and environmental conditions, dissolution and stability problems, excessive and non‐professional use and insufficient plasma concentration (Flammer, 1994; Powers, 2006; Vermeulen et al, 2002). Oral medicine (tube feeding) has its advantages such as giving precise doses and administering to the sick animal and lack of stability problems (Flammer, 1994; Powers, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…However, these methods also have certain disadvantages such as differences in drug intake among animals, changing water and feed intake according to disease and environmental conditions, dissolution and stability problems, excessive and non‐professional use and insufficient plasma concentration (Flammer, 1994; Powers, 2006; Vermeulen et al, 2002). Oral medicine (tube feeding) has its advantages such as giving precise doses and administering to the sick animal and lack of stability problems (Flammer, 1994; Powers, 2006). Parenteral medication in birds is an alternative route of administration for the shortest onset of effect in acute diseases and critical patients (Flammer, 1994; Vermeulen et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Parenteral medication in birds is an alternative route of administration for the shortest onset of effect in acute diseases and critical patients (Flammer, 1994; Vermeulen et al, 2002). Parenteral medication has its advantages such as the onset of the effect in a short time, better effectiveness, the adjustment of the exact dose, and the treatment of only the sick animal (Powers, 2006; Vermeulen et al, 2002). Oral and parenteral medications were preferred for geese for their advantages mentioned in this study.…”

Section: Discussionmentioning

confidence: 99%

“…It inhibits both structural COX−1 and inducible COX−2 enzyme responsible for PG synthesis from arachidonic acid (Alkan & Erdem, 2018;Moilanen & Kankaanranta, 1994). However, the inhibition of COX−1 and 2 by tolfenamic acid differ in terms of species (Landoni et al, 1996;Sidhu, Landoni, & Lees, 2005, 2006. In general, tolfenamic acid has a low potential for side effects (Eskerod, 1994;Hendel, 1994;Lascelles et al, 2007).…”

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confidence: 99%

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Pharmacokinetics of tolfenamic acid after different administration routes in geese (Anser cygnoides)

Türk

Tekeli

Çorum

et al. 2021

Vet Pharm & Therapeutics

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The pharmacokinetics and bioavailability of tolfenamic acid were determined in geese (Anser cygnoides) following intravenous (IV), intramuscular (IM), subcutaneous (SC), and oral administrations at 2 mg/kg dose. In this study, eight healthy geese (3.5 ± 0.5 kg) were used. The study was performed in four periods according to a crossover design with a 15‐day washout period between two administrations. The plasma concentrations of tolfenamic acid were analyzed using HPLC‐UV, and pharmacokinetic parameters were calculated by noncompartmental analysis. The elimination half‐life was 1.73, 2.51, 2.34, and 2.31 hr for IV, IM, SC, and oral routes, respectively. The volume of distribution at steady state and total clearance after IV administration were 0.25 L/kg and 0.16 L hr−1 kg−1, respectively. The peak plasma concentrations of tolfenamic acid after IM, SC, and oral administrations were 4.89, 2.94, and 2.92 μg/ml at 0.25, 0.75, and 1 hr, respectively. The bioavailability was 87.91, 77.87, and 76.03% for the IM, SC, and oral routes, respectively. Tolfenamic acid, which exhibits the good bioavailability and plasma concentration following IM, SC, and oral administrations at 2 mg/kg dose, may be useful in the treatment of inflammatory disease conditions in geese.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Pharmacokinetics of tolfenamic acid after different administration routes in geese (Anser cygnoides)

Türk

Tekeli

Çorum

et al. 2021

Vet Pharm & Therapeutics

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“…Intravenous and intraosseous routes of administration are the most efficient and most frequently used for blood volume replacement in birds during surgery or in critical situations (Powers 2006, Fowler 2007). Intraosseous infusion is more efficient than intravenous infusion because of the easy access and the higher stability.…”

Section: Introductionmentioning

confidence: 99%

Lactated Ringer's solution or 0.9% sodium chloride as fluid therapy in pigeons (Columba livia) submitted to humerus osteosynthesis

et al. 2015

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The study aimed to compare the effects of intraosseous infusion of lactated Ringer's and 0.9% sodium chloride solutions on the electrolytes and acid-base balance in pigeons submitted to humerus osteosynthesis. Eighteen pigeons were undergoing to isoflurane anesthesia by an avalvular circuit system. They were randomly assigned into two groups (n=9) receiving lactated Ringer's solution (LR) or 0.9% sodium chloride (SC), in a continuous infusion rate of 20mL/kg/h, by using an intraosseous catheter into the tibiotarsus during 60-minute anesthetic procedure. Heart rate (HR), and respiratory rate (RR) were measured every 10 min. Venous blood samples were collected at 0, 30 and 60 minutes to analyze blood pH, PvCO2, HCO3 -, Na+ and K+. Blood gases and electrolytes showed respiratory acidosis in both groups during induction, under physical restraint. This acidosis was evidenced by a decrease of pH since 0 min, associated with a compensatory response, observed by increasing of HCO3 - concentration, at 30 and 60 min. It was not observed any changes on Na+ and K+ serum concentrations. According to the results, there is no reason for choosing one of the two solutions, and it could be concluded that both fluid therapy solutions do not promote any impact on acid-base balance and electrolyte concentrations in pigeons submitted to humerus osteosynthesis.

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