Tectona grandis leaf extract, free and associated with nanoemulsions, as a possible photosensitizer of mouse melanoma B16 cell

Furtado, Cydia de Menezes; Faria, Fernando; Azevedo, Ricardo Bentes; Py-Daniel, Karen Rapp; Camara, Ana Lygia dos Santos; Silva, Jaqueline da; Oliveira, Everton de Holanda; Rodriguez, Anselmo Fortunato Ruiz; Degterev, I. A.

doi:10.1016/j.jphotobiol.2017.01.004

“…Barbed skullcap Southern China Pheophorbide a Porphyrins and derivatives [47,106] Lamiaceae Tectona grandis L.f. Teak Central America, Brazil, Subsaharian Africa, India and Pacific Asia Unknown Unknown [107] Lamiaceae Thymus vulgaris L.…”

Section: Scutellaria Barbata D Donmentioning

confidence: 99%

A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers

Petit,

Izambart,

Guillou

et al. 2023

Chemistry & Biodiversity

4

0

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This study provides a comprehensive overview of the current knowledge regarding phototoxic terrestrial plants and their phototoxic and photosensitizing metabolites. Within the 435,000 land plant species, only around 250 vascular plants have been documented as phototoxic or implicated in phototoxic occurrences in humans and animals. This work compiles a comprehensive catalog of these phototoxic plant species, organized alphabetically based on their taxonomic family. The dataset encompasses meticulous details including taxonomy, geographical distribution, vernacular names, and information on the nature and structure of their phototoxic and photosensitizing molecule(s). Subsequently, this study undertook an in‐depth investigation into phototoxic molecules, resulting in the compilation of a comprehensive and up‐to‐date list of phytochemicals exhibiting phototoxic or photosensitizing activity synthesized by terrestrial plants. For each identified molecule, an extensive review was conducted, encompassing discussions on its phototoxic activity, chemical family, occurrence in plant families or species, distribution within different plant tissues and organs, as well as the biogeographical locations of the producer species worldwide. The analysis also includes a thorough discussion on the potential use of these molecules for the development of new photosensitizers that could be used in topical or injectable formulations for antimicrobial and anticancer phototherapy as well as manufacturing of photoactive devices.

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“…For both hydro-alcoholic extract from Tectona grandis L.f. leaves (TGE) alone as well as extract incorporated into O/W NE with particles sizes approx. 20 nm and tested against melanoma B16 F10 cells photodynamic effect was estimated due to increasing toxicity under illumination with red light, however NE formulation was much less toxic towards normal cells in the dark compared to free TGE, which exhibited notable dark toxicity towards both B16 F10 and murine fibroblast NIH3T3 cells (Furtado et al 2017). Acai oil in NE, a novel photosensitizer for PDT, applied at PDT treatment of NIH/3T3 normal cells and B16F10 melanoma cell lines caused 85% cell death for melanoma cells, while maintaining high viability in normal cells and tumor volume reduction of 82% in tumor bearing C57BL/6 mice was observed following 5-fold treatment with PDT using acai oil in NE (Monge-Fuentes et al 2017).…”

Section: Nanoemulsions For Cancer Therapymentioning

confidence: 99%

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

Jampílek

¹

,

Kráľová

²

,

Campos

³

et al. 2019

Nanotechnology in the Life Sciences

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Nanotechnology providing "a new dimension" accompanied with new properties conferred to many current materials is widely used for production of a new generation of agrochemicals, in medicine it enables improved drug bioavailability, reducing undesirable side effects, minimizing non-specific uptake and specific targeting to certain target cells, while in food industry it has great importance in food protection and biofortification of food with valuable ingredients. In biobased nanoemulsions belonging to lipid nanocarriers plant oils used for oil phase, emulsifiers, biosurfactants, cosurfactants, targeting ligands on the surface of nanoemulsion (e.g., folate) or encapsulated active ingredients are of natural origin. The biocomponents of such nanoemulsions show low toxicity to living organisms, could protect encapsulated compounds for degradation, ensure their sustainable release and reduce the amount of active ingredient necessary for required effect. This chapter presents a comprehensive current overview of recent findings in the field of nanoemulsions and their utilization in agriculture and food industry, with the main emphasis on formulations encapsulating essential oils or plant extracts suitable as effective pesticide preparations as well as medicinal applications of bio-based nanoemulsions, where attention is paid to transdermal nanoemulsion formulations, the use of nanoemulsions in cancer therapy and for pulmonary and ocular drug delivery. Nanoemulsions formulated with natural emulsifiers, biosurfactants and biopolymers are presented and bio-based nanoemulsions of essential oils and their constituents as well as nanoemulsions with encapsulated vitamins, fatty acids and some bioactive compounds are discussed. Applications of nanoemulsions in edible coatings are outlined as well.

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“…For both hydro-alcoholic extract from Tectona grandis L.f. leaves (TGE) alone as well as extract incorporated into O/W NE with particles sizes approx. 20 nm and tested against melanoma B16 F10 cells photodynamic effect was estimated due to increasing toxicity under illumination with red light, however NE formulation was much less toxic towards normal cells in the dark compared to free TGE, which exhibited notable dark toxicity towards both B16 F10 and murine fibroblast NIH3T3 cells (Furtado et al 2017). Acai oil in NE, a novel photosensitizer for PDT, applied at PDT treatment of NIH/3T3 normal cells and B16F10 melanoma cell lines caused 85% cell death for melanoma cells, while maintaining high viability in normal cells and tumor volume reduction of 82% in tumor bearing C57BL/6 mice was observed following 5-fold treatment with PDT using acai oil in NE (Monge-Fuentes et al 2017).…”

Section: Nanoemulsions For Cancer Therapymentioning

confidence: 99%

Nanobiotechnology in Bioformulations

2019

Nanotechnology in the Life Sciences

View full text Add to dashboard Cite

Nanotechnology providing "a new dimension" accompanied with new properties conferred to many current materials is widely used for production of a new generation of agrochemicals, in medicine it enables improved drug bioavailability, reducing undesirable side effects, minimizing non-specific uptake and specific targeting to certain target cells, while in food industry it has great importance in food protection and biofortification of food with valuable ingredients. In biobased nanoemulsions belonging to lipid nanocarriers plant oils used for oil phase, emulsifiers, biosurfactants, cosurfactants, targeting ligands on the surface of nanoemulsion (e.g., folate) or encapsulated active ingredients are of natural origin. The biocomponents of such nanoemulsions show low toxicity to living organisms, could protect encapsulated compounds for degradation, ensure their sustainable release and reduce the amount of active ingredient necessary for required effect. This chapter presents a comprehensive current overview of recent findings in the field of nanoemulsions and their utilization in agriculture and food industry, with the main emphasis on formulations encapsulating essential oils or plant extracts suitable as effective pesticide preparations as well as medicinal applications of bio-based nanoemulsions, where attention is paid to transdermal nanoemulsion formulations, the use of nanoemulsions in cancer therapy and for pulmonary and ocular drug delivery. Nanoemulsions formulated with natural emulsifiers, biosurfactants and biopolymers are presented and bio-based nanoemulsions of essential oils and their constituents as well as nanoemulsions with encapsulated vitamins, fatty acids and some bioactive compounds are discussed. Applications of nanoemulsions in edible coatings are outlined as well.

show abstract

Tectona grandis leaf extract, free and associated with nanoemulsions, as a possible photosensitizer of mouse melanoma B16 cell

Cited by 13 publications

References 14 publications

A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers

A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

Nanobiotechnology in Bioformulations

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