Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome

Physiological Modulation of Intestinal Motility by Enteric Dopaminergic Neurons and the D2Receptor: Analysis of Dopamine Receptor Expression, Location, Development, and Function in Wild-Type and Knock-Out Mice

“…5-HT 4 receptors, moreover, like D 2 , are most concentrated on neurites within enteric ganglia (Liu et al, 2005). Domperidone (Barone, 1999;Drolet et al, 2000) and tegaserod are both used therapeutically as prokinetic agents, although domperidone is often thought to be more effective on the proximal gut (Longo and Vernava, 1993;Jost, 1997) and so has been used to relieve the symptoms of dyspepsia and gastroparesis (Horowitz and Fraser, 1995;Tonini et al, 2004), whereas tegaserod is used to treat chronic constipation and constipation-predominant irritable bowel syndrome (Prather et al, 2000;Muller-Lissner et al, 2001;Johanson, 2004;Galligan and Vanner, 2005). Domperidone and DA, however, have both been shown to exert effects on the colon and rectum as well as on the upper bowel (Wiley and Owyang, 1987), whereas tegaserod accelerates gastric emptying (Degen et al, 2001;James et al, 2004;Crowell et al, 2005) and has also been useful in treating dyspepsia and gastroparesis (Banh et al, 2005;Galligan and Vanner, 2005;Zuberi et al, 2005).…”

Updates on treatment of irritable bowel syndrome

“…Tegaserod is a 5-HT4 agonist that was initially approved by the FDA for use in female patients with IBS-C, and in men and women under the age of 65 with chronic idiopathic constipation. It stimulates intestinal secretion of water and chloride and decreases the nociceptive response to rectal distension [58] . Several large, randomized-trials have shown that tegaserod has a significant impact on a patient's overall assessment of global relief, and that it statistically improves abdominal pain and bloating [59][60][61][62] .…”

The effects of tegaserod on oesophageal function and bolus transport in healthy volunteers: studies using concurrent high‐resolution manometry and videofluoroscopy

“…1,2 Tegaserod accelerates gastric emptying, small bowel and colonic transit; [2][3][4] however, its effects on oesophageal motor function and bolus transport are unknown. The primary functions of the oesophagus are the transport of food and fluid from the mouth to the stomach and the prevention of gastro-oesophageal reflux.…”