Telangiectatic osteosarcoma affecting the mandible

Naik, LRKumaraswamy; Shetty, Pushparaja; Teerthanath, S; Jagadeesh, HMakannavar

doi:10.4103/0973-029x.141371

Cited by 7 publications

(15 citation statements)

References 11 publications

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“…[ 1 ] A more frequent occurrence is seen in men than women with a ratio of about 1.5:1 and mandibular lesions reported more often than maxillary though some studies suggest equal distribution in both. [ 7 8 9 10 ] In the present case, the patient was a 56-year-old male presenting with a mandibular lesion, which is in accordance with the literature.…”

Section: Discussionsupporting

confidence: 89%

“…It is well known that JOS of various histological types shows local recurrences more frequently than distant metastasis. [ 7 15 ] OS, in this case, was graded as 3/4 based on morphologic observation, which is considered a high grade by the WHO and requires periodic follow-up postsurgery and chemotherapy/radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…JOS is known to have a comparably higher survival rate and a lower incidence of metastasis than OS occurring in other areas of the body. [ 1 4 6 7 ] Early diagnosis and adequate surgical resection is the key to its better prognosis. [ 4 ] This could also be attributed to a better histological differentiation of JOS and a higher mean age group of its occurrence.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Osteosarcoma

Manchanda¹,

Narang²,

Mahajan³

2021

Journal of Oral and Maxillofacial Pathology

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Osteosarcoma (OS) comprises 2.1% of all malignant oral and maxillofacial tumors. OS arising from the jaw OS differs from OS of the long bones in its biological behavior, presenting a lower incidence of metastasis and a better prognosis. The morphologic and behavioral heterogeneity observed in OS and the perplexity of the varied histological features mimicking other primary and metastatic bone tumors has emphasized the need of advanced molecular techniques in its diagnosis. Hereby, we present a case of OS which was diagnosed by immunohistochemical analysis, aiding in establishing its histogenetic origin.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Osteosarcoma

Manchanda¹,

Narang²,

Mahajan³

2021

Journal of Oral and Maxillofacial Pathology

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“…TOS consists of multiple characteristic dilated aneurysmal cavities containing blood, with highly malignant sarcoma cells being present at the peripheral margins and septations surrounding these cavities (7). As this is a very rare form of cancer, no largescale clinical studies of TOS have been conducted to date, and case reports (8)(9)(10) and animal studies (11)(12)(13) thus account for the bulk of research related to this condition. Given these limitations, the clinical characteristics and prognosis of TOS remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and prognosis of telangiectatic osteosarcoma: a population-based study using the Surveillance, Epidemiology and End Results (SEER) database

Xu¹,

Dai²,

Yang³

et al. 2021

Ann Transl Med

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Background: Telangiectatic osteosarcoma (TOS) is a rare type of osteosarcoma for which limited clinical data is available. Furthermore, the clinical characteristics and prognosis of TOS remain unclear.Methods: A large population-based cohort analysis was conducted using the Surveillance, Epidemiology and End Results (SEER) registry. The data of TOS and conventional osteosarcoma (COS) patients from 2000 to 2017 were collected. The categorical variables were assessed by Chi-squared tests. Kaplan-Meier curves and log-rank (Mantel-Cox) tests were used to examine the survival outcomes between the groups.Cox proportional hazard models were used for univariate and multivariate analyses of TOS patient survivalrelated variables.Results: A total of 141 TOS patients and 2961 COS patients were included in this analysis, and the mean age at diagnosis was 23.5 and 29.4 years, respectively. Compared to COS patients, TOS patients were more likely to be under 20 years old (61.7% vs. 51.7%, P=0.022), and without a second peak of incidence after 60 years of age. The median overall survival (mOS) of TOS patients was not reached compared to a median survival of 84 months for COS patients (hazard ratio 0.75, 95% confidence interval 0.59 to 0.95, P=0.0175).After adjusting these data for age at diagnosis, stage, and surgery at the primary site, no significant differences in mOS were observed between the two groups. In univariate analyses, being under 20 years of age, having localized or regional stage disease, and having undergone surgery were associated with a decreased risk of death. Subsequent multivariate analysis indicated that age at diagnosis, stage, and surgery at the primary site were all independent predictors of prognosis in TOS patients.Conclusions: Patients with TOS were younger than patients with COS and did not show a second peak after 60 years of age. Age, summary stage at diagnosis, and surgery at the primary site were independent predictors of survival for TOS patients.

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“…Telangiectatic osteosarcoma is a less common form of osteosarcoma (Ennazli et al., ). Telangiectatic osteosarcoma has been reported in the humans, dog and horse (Brellou et al., ; Ennazli et al., ; Gutierrez‐Nibeyro, Sullins, & Powers, ; Naik, Shetty, Teerthanath, & Jagadeesh, ). Also primary telangiectatic osteosarcoma of a non‐functioning kidney (Gordillo et al., ) has been reported in humans.…”

mentioning

confidence: 99%