Telemetric real-time sensor for the detection of acute upper gastrointestinal bleeding

Schostek, Sebastian; Zimmermann, Melanie; Keller, Jan; Fode, Mario; Melbert, Michael; Schurr, M. O.; Gottwald, Thomas; Prosst, Ruediger L.

doi:10.1016/j.bios.2015.11.073

Cited by 35 publications

(33 citation statements)

References 5 publications

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“…A ratiometric intensity‐based sensor was developed to detect acute upper GI bleeding . Blood has higher absorption of violet light (415 nm) than red light (720 nm).…”

Section: Capsules For Robotic Sensingmentioning

confidence: 99%

Robotics in the Gut

Min

Yang

et al. 2019

Advanced Therapeutics

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Since the advent of ingestible temperature sensors and capsule endoscopes, rapid advances in electronics, robotics, nanotechnology, and material sciences have opened the door for the development of novel medical ingestible robots. The untethered robots provide direct, non-invasive access to the entire gastrointestinal (GI) tract. Furthermore, the tissues, gases, and fluids of the gastrointestinal lumen contain a multitude of biomarkers indicative of gut diseases and health. Ingestible medical robots equipped with advanced imaging and sensing techniques can enable the diagnosis and monitoring of diseases, while providing a better pathophysiological understanding of gastrointestinal disorders. In addition, various robotic actuation mechanisms in the macro-and microscale can realize enhanced drug delivery and surgical interventions for the treatment of diseases. In this paper, an overview of recent advances in ingestible robots toward imaging, sensing, drug delivery, and surgical applications in the GI tract is provided. Key challenges and strategies for the development of novel ingestible robots and future directions of ingestible robots toward precision medicine are also discussed.

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“…A ratiometric intensity‐based sensor was developed to detect acute upper GI bleeding . Blood has higher absorption of violet light (415 nm) than red light (720 nm).…”

Section: Capsules For Robotic Sensingmentioning

confidence: 99%

Robotics in the Gut

Min

Yang

et al. 2019

Advanced Therapeutics

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“…46 Recently, transluminal impedance measurements 47 or electrical permittivity 48 has also been proposed to be important indicators of GI health monitoring. Other recent developments include an LED-based WCE that can detect bleeding in the upper GI tract 49 and an FDA-approved temperature monitoring pill (CorTemp â sensor from HQ Inc) that is accurate to AE0.1°C. 50 Therapeutic capabilities are currently lacking in most commercial capsules.…”

Section: A2 Physiological Sensing and Therapeuticsmentioning

confidence: 99%

Magnetically guided capsule endoscopy

et al. 2017

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Wireless capsule endoscopy (WCE) is a powerful tool for medical screening and diagnosis, where a small capsule is swallowed and moved by means of natural peristalsis and gravity through the human gastrointestinal (GI) tract. The camera-integrated capsule allows for visualization of the small intestine, a region which was previously inaccessible to classical flexible endoscopy. As a diagnostic tool, it allows to localize the sources of bleedings in the middle part of the gastrointestinal tract and to identify diseases, such as inflammatory bowel disease (Crohn's disease), polyposis syndrome, and tumors. The screening and diagnostic efficacy of the WCE, especially in the stomach region, is hampered by a variety of technical challenges like the lack of active capsular position and orientation control. Therapeutic functionality is absent in most commercial capsules, due to constraints in capsular volume and energy storage. The possibility of using body-exogenous magnetic fields to guide, orient, power, and operate the capsule and its mechanisms has led to increasing research in Magnetically Guided Capsule Endoscopy (MGCE). This work shortly reviews the history and state-of-art in WCE technology. It highlights the magnetic technologies for advancing diagnostic and therapeutic functionalities of WCE. Not restricting itself to the GI tract, the review further investigates the technological developments in magnetically guided microrobots that can navigate through the various air-and fluid-filled lumina and cavities in the body for minimally invasive medicine.

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“…To date, the novel capsule device has only been tested in ex vivo experiments [1]. Thus, current database includes no data on humans.…”

Section: Introductionmentioning

confidence: 99%