Telmisartan – an effective antihypertensive for 24-hour blood pressure control

Chambers, Scott; Schächter, Michael; Morrell, Jonathan; Kassianos, George; Gaw, Allan; Kirby, Michael; Tamargo, Juan; Yawn, Barbara P.; Yawn, Roy A.; Barakat, Khalid; Brown, Pam; Dalrymple, Jamie; Elward, Kurt; Ganiats, Ted; Halpin, David; LeFevre, Mike; North, Frederick; Price, David A.; Rasmussen, Jill; Spann, Steven; Stevens, Richard; Tallia, Alfred F.; Uden, Don; Waite, Marion; Waller, Derek G.

doi:10.7573/dic.212220

Cited by 5 publications

(6 citation statements)

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“…Telmisartan provides effective blood pressure control over 24 hours and has renoprotective properties in humans. This fact has been demonstrated in hypertensive patients including the elderly and those with comorbid conditions such as diabetes and renal impairment 24–27. This drug decreased serum glucose and serum triglyceride levels, and acted as partial agonist of the peroxisome proliferator‐activated receptor‐γ.…”

Section: Introductionmentioning

confidence: 89%

“…This fact has been demonstrated in hypertensive patients including the elderly and those with comorbid conditions such as diabetes and renal impairment. [24][25][26][27] This drug decreased serum glucose and serum triglyceride levels, and acted as partial agonist of the peroxisome proliferator-activated receptor-γ. It has been associated with significant reduction in left ventricular mass index, wall thickness and left atrial volumes.…”

Section: Introductionmentioning

confidence: 99%

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Effect of a combination of telmisartan and amlodipine in hypertensive dogs

Caro-Vadillo

Daza-González

Gonzalez-Alonso-Alegre

et al. 2018

Vet Record Case Reports

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Systemic hypertension (SHT) in dogs is considered a health risk factor. Telmisartan is a well-known antihypertensive agent in humans. There are limited reports about its efficacy in dogs. Five dogs with primary and secondary SHT refractory to the combined treatment of benazepril and amlodipine had a successful control of systolic arterial blood pressure (SBP) when telmisartan was combined with amlodipine. SBP showed a significant reduction after any treatment, but only reached successful control when amlodipine plus telmisartan was administered (median SBP: 215 mmHg before treatment [min-max: 180–240 mmHg]; 180 mmHg for amlodipine plus benazepril treatment [min-max: 170–210 mmHg]; 142 mmHg after amlodipine plus telmisartan treatment [min-max: 120–165 mmHg]). This control remained stable in the long-term follow-up (average 5.2 months). In the cases reported, the telmisartan plus amlodipine treatment showed good efficacy in the control of SHT, regardless of cause, and was well tolerated in all patients.

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Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effect of a combination of telmisartan and amlodipine in hypertensive dogs

Caro-Vadillo

Daza-González

Gonzalez-Alonso-Alegre

et al. 2018

Vet Record Case Reports

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“…Telmisartan not only blocks the angiotensin receptor, but also plays a role as a partial agonist of peroxisome proliferator-activated receptor-γ (PPAR-γ), thereby activating PPAR-γ (Chambers, 2008& Funao et al, 2009. The activation causes PPAR-γ form a heterodimer with retinoid X receptors (RXR), creating a corepressor that can inhibit TGF-β1 gene expression (Rotman & Wahli, 2010).…”

Section: Introductionmentioning

confidence: 99%

The Influence of Telmisartan on the Expression of BMP-7 in Rat Kidneys Induced by 8% NaCl

Pahmi

Nufus

Muliani

2022

JIKF

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Excessive salt intake is one of the factors of high blood pressure leading to kidney disease while telmisartan is one of the antihypertensive drugs used in therapy. Telmisartan not only blocks the angiotensin receptor, which leads to a reduction in blood pressure, but also activates the peroxisome proliferator-activated receptor gamma (PPAR-γ), inhibits the expression of transforming growth factor beta-1 (TGFβ-1) and increases bone morphogenetic protein-7 (BMP-7). This experiment examines whether telmisartan increases the expression of BMP-7 in excess NaCl-induced Wistar rats. For this study, 25 male Wistars aged 2.5 to 3 months and rats weighing 100 to 150 g were used.They were grouped into 5, each consists of 5 rats. Group I (G I) as the first negative control received neither NaCl nor telmisartan. G II as the second negative control received NaCl but no telmisartan. G III, IV and V received NaCl and telmisartan 3, 6 and 12 mg/kg body weight. Treatments were given every day for 8 weeks.On day 56, all rats were sacrificed by neck dislocation and operated on to remove the kidney. BMP-7 expression was measured by immunohistochemical technique. Data were expressed as mean ± standard error. They were analyzed by parametric (ANOVA) or nonparametric (Kruskal-Wallis) testing. A value of p ≤ 0.05 was considered statistically significant. The results showed that the expression of the intraglomerular and extraglomerular protein BMP-7 was higher in the telmisartan-treated group of Wistar rats than in the negative control group (pand<0.05). In summary, intraglomerular and extraglomerular BMP-7 protein expression was higher in male Wistar rats treated with telmisartan and induced with 8% sodium chloride than in negative control group members.

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“…Most of antihypertensive medication that largely consumed by society is angiotensin receptor blockers (ARBs), such as telmisartan. Telmisartan not only inhibits angiotensin receptor, however also it can be as agonist partial peroxisome proliferator activated receptor-γ (PPAR-γ), so as it stimulates PPAR-γ [13,14]. The activation drives PPAR-γ shapes heterodimer with retinoid X receptors (RXRs) so as co-repressor is synthesized that may block TGF-β1 expression [15].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Telmisartan on Collagen Percentages by Picrosirius Staining in the Glomerular Renal Organ of 8% NaCl-Induced Rats

Pahmi

Sidratullah

Ramadhian

2020

JSSCR

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Excessive salt consumption is one of the hypertension and kidney disease factors, while telmisartan is one of antihypertensive drugs used in the therapy. Telmisartan not only blocks angiotensin receptor which leads to the decrease of blood pressure, but also activates peroxisome proliferator activated receptor gamma (PPAR-γ) and inhibits transforming growth expression factor of beta-1 (TGFβ-1). Whether telmisartan decreases the kidney collagen volume fraction of excessive NaCl-induced Wistar rats are studied in this experiment. Twenty five male Wistars 2.5-3 months of age and 100-150 g BW rats were used in this research. They were grouped into 5, each consists of 5 rats. Group I (G I) as first negative control did not receive NaCl and telmisartan. G II as second negative control received NaCl but not telmisartan. G III, IV and V received NaCl and telmisartan 3, 6 and 12 mg/kg BW. The treatments were given every day within 8 weeks. At the day of 56 all rats were sacrificed by mean of neck dislocation and operated to take the kidney. The collagen was stained by picrosirius red staining. Data were expressed as mean ± standard deviation. They were analyzed by parametric test (analysis of variance-ANOVA and paired samples t-test) or nonparametric test (Kruskal-Wallis). A value of p0.05 was considered statistically significant. The results showed that intraglomerular and extraglomerular collagen volume fraction were lower in telmisartan-treated Wistar rats group than negative control group (0.05p0.05). In conclusion, intraglomerular and extraglomerular collagen volume fraction were lower in 8% sodium chloride-induced and telmisartan-treated male Wistar rats than the items of negative control group.

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Telmisartan – an effective antihypertensive for 24-hour blood pressure control

Cited by 5 publications

References 0 publications

Effect of a combination of telmisartan and amlodipine in hypertensive dogs

Effect of a combination of telmisartan and amlodipine in hypertensive dogs

The Influence of Telmisartan on the Expression of BMP-7 in Rat Kidneys Induced by 8% NaCl

The Effect of Telmisartan on Collagen Percentages by Picrosirius Staining in the Glomerular Renal Organ of 8% NaCl-Induced Rats

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