Telocyte morphologies and potential roles in diseases

Zheng, Yonghua; Bai, Chunxue; Wang, Xiangdong

doi:10.1002/jcp.23022

Cited by 82 publications

(97 citation statements)

References 57 publications

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“…and Zheng et al, [2012] suggested that telocytes are located near vessels; they might be involved in blood flow regulation. observed telocyte contacts with nerve fibers and/ or smooth muscle cells in the human uterine tube.…”

Section: Discussionmentioning

confidence: 99%

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Abd‐Elhafeez

Soliman

2016

Cells Tissues Organs

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Telocytes are a special type of interstitial cells characterized by distinctive cellular extensions with alternating thin segments (podomers) and dilations (podoms). Telocytes establish contact with various cells and structures, but their role in the regulation of the function of many cell types is still obscure. The aim of the current study was to investigate the morphology, histochemistry, and immunohistochemistry of telocytes, and their distribution, organization, and morphometric measurements in different layers of the adult bovine uterine tube. Telocytes showed positive immunostaining for CD117, S-100 protein, vimentin, desmin, α-smooth muscle actin, tubulin, laminin, estrogen receptor-α, and progesterone receptor. They were organized in different types of sheaths: subepithelial, inner/outer perimuscular, and intramuscular sheaths. Telocytes were scattered in the lamina propria, in the muscular layer, and the serosa. According to their size, they were grouped into different types of telocytes: small, large, and giant telocytes. Small telocytes were the most common type and located in all layers; large telocytes were observed in the epithelium, lamina propria, and inner/outer perimuscular and intramuscular sheaths, and giant telocytes were found in the external layer of the outer perimuscular sheath. Telocytes were connected by thin and thick telopodes (fenestrated membranes). Fenestrated membranes enabled connections between telocytes along the entire muscular wall of the uterine tube. Telocytes established an extensive biological network of different types of cells and structures, including epithelial, muscular, and mast cells, blood vessels, glomus, and nerve fibers. We hypothesize that telocytes help to organize the functional coordination between different types of cells in the uterine tube.

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Section: Discussionmentioning

confidence: 99%

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Abd‐Elhafeez

Soliman

2016

Cells Tissues Organs

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“…In conclusion, potential relationships between telocytes and other cells in lung diseases are proposed and summarized by Zheng et al [42]. Telocytes may be a new target cell for the prevention and treatment of lung diseases, although there is still a need for further studies on the details of their biological functions during the pathologic status of the lung.…”

Section: Zheng Bai and Wangmentioning

confidence: 99%

Potential significance of telocytes in the pathogenesis of lung diseases

Zheng

Bai

Wang³

2012

Expert Review of Respiratory Medicine

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Multiple cells play critical roles in the pathogenesis of lung diseases, even though the exact mechanisms are still not clear. Telocytes are characterized by telopodes, which are thin and long prolongations, and a small amount of cytoplasm rich with mitochondria, as shown by immune-positive staining against CD34, c-kit and vimentin. Telocytes have been found in many organs of mammals, including the trachea and lung. This report summarizes the latest findings associated with telocytes, with a special focus on the lung, and demonstrates that telocytes exist in the smooth muscle layer under cartilage and bronchiole in the lung, and also in the interstitial space of alveoli. Telocytes have a mediate connection with epithelial cells and direct connection with smooth muscle cells both in blood vessels and bronchiole in the lung. Telocytes also have a close relationship with other cell types, such as immune cells and stem cells. Telopodes appear with dichotomous branching and alternation of podom and podomer, forming a 3D network structure with complex homo- and hetero-cellular junctions. All characteristics of telocytes in lung tissue indicate that telocytes may play a potential, but important, role in the pathogenesis of lung diseases.

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“…The phenotype of TCs was characterized by CD34, c-kit, vimentin and caveolin-1 positivity [21]. TCs in different tissues display different phenotypes [22,23]. Cardiac TCs express vimentin, CD34 and PDGFR-β [16].…”

Section: Introductionmentioning

confidence: 99%

Multiple immunophenotypes of cardiac telocytes

Chang

et al. 2015

Experimental Cell Research

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Telocyte morphologies and potential roles in diseases

Cited by 82 publications

References 57 publications

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Potential significance of telocytes in the pathogenesis of lung diseases

Multiple immunophenotypes of cardiac telocytes

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