Telocytes in the human ascending aorta: Characterization and exosome‐related KLF‐4/VEGF‐A expression

Aschacher, Thomas; Schmidt, Katy; Aschacher, Olivia; Eichmair, Eva; Baranyi, Ulrike; Winkler, Bernhard; Grabenwoeger, Martin; Spittler, Andreas; Enzmann, Florian; Meßner, Barbara; Riebandt, Julia; Laufer, Guenther; Bergmann, Michael; Ehrlich, Marek

doi:10.1111/jcmm.16919

Cited by 16 publications

(10 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, we showed that telocytes are involved in HTA, and the number of telocytes was positively correlated with increases in chronic disease and aortic diameter in TAA samples [ 45 , 46 ]. An increase in the number of TCs seems to be positively related to chronic hypoxia and/or cellular stress of the tissue.…”

Section: Resultsmentioning

confidence: 99%

Impacts of Telomeric Length, Chronic Hypoxia, Senescence, and Senescence-Associated Secretory Phenotype on the Development of Thoracic Aortic Aneurysm

Aschacher

Geisler

Lenz

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

Thoracic aortic aneurysm (TAA) is an age-related and life-threatening vascular disease. Telomere shortening is a predictor of age-related diseases, and its progression is associated with premature vascular disease. The aim of the present work was to investigate the impacts of chronic hypoxia and telomeric DNA damage on cellular homeostasis and vascular degeneration of TAA. We analyzed healthy and aortic aneurysm specimens (215 samples) for telomere length (TL), chronic DNA damage, and resulting changes in cellular homeostasis, focusing on senescence and apoptosis. Compared with healthy thoracic aorta (HTA), patients with tricuspid aortic valve (TAV) showed telomere shortening with increasing TAA size, in contrast to genetically predisposed bicuspid aortic valve (BAV). In addition, TL was associated with chronic hypoxia and telomeric DNA damage and with the induction of senescence-associated secretory phenotype (SASP). TAA-TAV specimens showed a significant difference in SASP-marker expression of IL-6, NF-κB, mTOR, and cell-cycle regulators (γH2AX, Rb, p53, p21), compared to HTA and TAA-BAV. Furthermore, we observed an increase in CD163+ macrophages and a correlation between hypoxic DNA damage and the number of aortic telocytes. We conclude that chronic hypoxia is associated with telomeric DNA damage and the induction of SASP in a diseased aortic wall, promising a new therapeutic target.

show abstract

Section: Resultsmentioning

confidence: 99%

Impacts of Telomeric Length, Chronic Hypoxia, Senescence, and Senescence-Associated Secretory Phenotype on the Development of Thoracic Aortic Aneurysm

Aschacher

Geisler

Lenz

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…TCs could promote angiogenesis [ 37 ]. Aschacher et al describe these cells in blood vessels and hypothesise that they might be involved in aortic tissue homeostasis by shedding microvesicles (sMVs) and exosomes containing angiogenic factors, such as VEGF—A [ 38 ]. Our results show that a declining number of myometrial and oviductal TCs in patients with uterine myoma correlates with a low expression of VEGF in the same samples of tissues.…”

Section: Discussionmentioning

confidence: 99%

Oviductal Oxygen Homeostasis in Patients with Uterine Myoma: Correlation between Hypoxia and Telocytes

Wrona¹,

Aleksandrovych

Bereza

et al. 2022

IJMS

View full text Add to dashboard Cite

Oxygen balance is crucial for angiogenesis, immunity, and tissue repair. The human oviduct is essential for reproductive function, and any imbalance in homeostasis leads to fertility disturbances and might be a reason for ectopic pregnancy development. Uterine myoma is a widespread benign tumour, which is often accompanied by infertility. Telocytes have been discussed in the contexts of motility, fibrosis development, and angiogenesis. We observed the oviducts from patients with and without uterine myoma, comparing the expression of HIF-1, HO, VEGF and its receptor, NOS, oestrogen, and progesterone receptors by immunolabeling. The myometrial and oviductal telocytes were also compared in both groups. Biochemical analyses were conducted for FSH, LH, AMH, sFlt, oestrogen, and progesterone in blood samples. Patients with uterine myoma have different expressions of sex steroid receptors and an increased number of telocytes. The decreasing VEFG expression was compensated by the rise in the HIF-1 and NOS expression. Blood biochemical analyses revealed a higher progesterone level and lower AMH in patients with uterine myoma. No differences in sFlt, FSH, and LF were observed. Uterine myoma impacts oviduct oxygen homeostasis and might cause fertility disturbances (uterine and oviductal infertility factors).

show abstract

“…(Heo et al, 2020) PDGF-A The change of extracellular matrix composition was simulated by PDGF-A, which is important for the formation of aortic aneurysms through the induction of pathological phenotype switching of SMCs. (Aschacher et al, 2021) PDGF-AA Exosomes including PDGF-AA derived from differentiating human skeletal myoblasts (HSkM) can induce in vitro myogenesis of human adipose-derived stem cells (HASCs) and improves in vivo muscle regeneration. (Choi et al, 2016) PDGF-AA,PDGF-BB…”

Section: Parkinson's Disease Treatment Based On Single-cell Transcrip...mentioning

confidence: 99%

Insights Into the Role of Platelet-Derived Growth Factors: Implications for Parkinson’s Disease Pathogenesis and Treatment

Huang

Zhang

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

Parkinson’s disease (PD), the second most common neurodegenerative disease after Alzheimer’s disease, commonly occurs in the elderly population, causing a significant medical and economic burden to the aging society worldwide. At present, there are few effective methods that achieve satisfactory clinical results in the treatment of PD. Platelet-derived growth factors (PDGFs) and platelet-derived growth factor receptors (PDGFRs) are important neurotrophic factors that are expressed in various cell types. Their unique structures allow for specific binding that can effectively regulate vital functions in the nervous system. In this review, we summarized the possible mechanisms by which PDGFs/PDGFRs regulate the occurrence and development of PD by affecting oxidative stress, mitochondrial function, protein folding and aggregation, Ca2+ homeostasis, and cell neuroinflammation. These modes of action mainly depend on the type and distribution of PDGFs in different nerve cells. We also summarized the possible clinical applications and prospects for PDGF in the treatment of PD, especially in genetic treatment. Recent advances have shown that PDGFs have contradictory roles within the central nervous system (CNS). Although they exert neuroprotective effects through multiple pathways, they are also associated with the disruption of the blood–brain barrier (BBB). Our recommendations based on our findings include further investigation of the contradictory neurotrophic and neurotoxic effects of the PDGFs acting on the CNS.

show abstract

Telocytes in the human ascending aorta: Characterization and exosome‐related KLF‐4/VEGF‐A expression

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 16 publications

References 49 publications

Impacts of Telomeric Length, Chronic Hypoxia, Senescence, and Senescence-Associated Secretory Phenotype on the Development of Thoracic Aortic Aneurysm

Impacts of Telomeric Length, Chronic Hypoxia, Senescence, and Senescence-Associated Secretory Phenotype on the Development of Thoracic Aortic Aneurysm

Oviductal Oxygen Homeostasis in Patients with Uterine Myoma: Correlation between Hypoxia and Telocytes

Insights Into the Role of Platelet-Derived Growth Factors: Implications for Parkinson’s Disease Pathogenesis and Treatment

Contact Info

Product

Resources

About