Telomerase activity and telomere length in women with breast cancer or without malignancy: A systematic review and meta-analysis

Benites-Zapata, Vicente A.; Ulloque-Badaracco, Juan R.; Alarcón-Braga, Esteban A.; Fernández-Alonso, Ana M.; López-Baena, María T.; Pérez-López, Faustino R.

doi:10.1016/j.maturitas.2023.107882

Cited by 5 publications

(2 citation statements)

References 65 publications

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“…Telomerase is a ribonucleoprotein that act as an enzyme for catalysing the replenishing of these sequences which are gradually lost each time a cell undergoes division [47]. This enzyme activity is typically elevated in germ line, embryonic cells, and certain stem cells that are constantly dividing [48]. Nevertheless, the enzyme's function is suppressed in most somatic cells [31].…”

Section: Telomeres and Telomerase Implication In Health And Diseasementioning

confidence: 99%

Telomeres and Telomerase as Promising Targets for Malaria Therapy: A Comprehensive Review

Wakai,

Anzaku,

Afolabi

2024

Preprint

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Infection with the malaria parasite Plasmodium, remains a major cause of illness and death world-wide. The development of evasion strategies by the parasite from host immunity and its adaptability to antimalarial drugs has raised the urgency for developing new strategies to combat this disease. One promising avenue is targeting telomeres – sequences found at chromosome termini– and telomerase – the enzyme that catalysis synthesis of telomeres using an intrinsic RNA template. As telomeres shorten critically, cells undergo replicative senescence or apoptosis. Plasmodium, lacking telomerase activity in its human stages, exploits alternative mechanisms, accelerating telomere shortening, aging, and immune evasion. Chemical telomerase inhibitors show promise as antimalarials. In this review, we examine the potential of targeting this system in malaria therapy, with telomerase inhibitors offering a novel approach. A systematic search on PubMed using Boolean techniques identified 246 relevant articles from 1985 to March 31, 2024. After filtering, 43 articles met inclusion criteria, supplemented by snowball sampling. The telomerase inhibitor drug strategy is widely applicable against cancer. However, given the drugability of telomerase and the absolute requirement for active telomere maintenance in the vast majority of parasites including plasmodium, telomerase and telomere maintenance could well represent the Achilles heel of the parasite

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Section: Telomeres and Telomerase Implication In Health And Diseasementioning

confidence: 99%

Telomeres and Telomerase as Promising Targets for Malaria Therapy: A Comprehensive Review

Wakai,

Anzaku,

Afolabi

2024

Preprint

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“…These types of infections contribute to cancer development through multiple molecular pathways. For example, a virus can inhibit apoptosis in the infected cell [5], it can integrate its DNA in an oncogenic region of the cell's DNA [6], activate telomerase, which contributes to cellular immortality [7], or induce mitosis in fully differentiated cells leading to their uncontrollable division [8]. Moreover, the effect of many oncogenic viruses is propagated through affecting anti-oncogenic proteins and interfering with the function of cell cycle regulators such as p53, RAS, retinoblastoma protein (Rb), and many others [8,9].…”

Section: Introductionmentioning

confidence: 99%

Association of Human Papilloma Virus, Cytomegalovirus, and Epstein–Barr Virus with Breast Cancer in Jordanian Women

Khasawneh,

Himsawi,

Sammour

et al. 2024

Medicina

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Background and Objectives: The investigation of oncogenic viruses and their potential association with breast cancer (BC) remains an intriguing area of study. The current work aims to assess evidence of three specific viruses, human papillomavirus (HPV), cytomegalovirus (CMV), and Epstein–Barr virus (EBV) in BC samples and to explore their relationship with relevant clinicopathological variables. Materials and Methods: The analysis involved BC samples from 110 Jordanian female patients diagnosed with BC and breast tissue samples from 30 control patients with no evidence of breast malignancy, investigated using real-time PCR. The findings were then correlated with various clinico-pathological characteristics of BC. Results: HPV was detected in 27 (24.5%), CMV in 15 (13.6%), and EBV in 18 (16.4%) BC patients. None of the control samples was positive for HPV or CMV while EBV was detected in only one (3.3%) sample. While (HPV/EBV), (HPV/CMV), and (EBV/CMV) co-infections were reported in 1.8%, 2.7%, and 5.5%, respectively, coinfection with the three viruses (HPV/CMV/EBV) was not reported in our cohort. A statistically significant association was observed between HPV status and age (p = 0.047), and between clinical stage and CMV infection (p = 0.015). Conclusions: Our findings indicate the presence or co-presence of HPV, CMV, and EBV in the BC subpopulation, suggesting a potential role in its development and/or progression. Further investigation is required to elucidate the underlying mechanisms that account for the exact role of oncoviruses in breast carcinogenesis.

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Association between human telomerase reverse transcriptase (hTERT) MNS16A polymorphism and risk of breast cancer

Salehi-Reyhani,

Saadat

2024

Mol Biol Rep

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Telomerase activity and telomere length in women with breast cancer or without malignancy: A systematic review and meta-analysis

Cited by 5 publications

References 65 publications

Telomeres and Telomerase as Promising Targets for Malaria Therapy: A Comprehensive Review

Telomeres and Telomerase as Promising Targets for Malaria Therapy: A Comprehensive Review

Association of Human Papilloma Virus, Cytomegalovirus, and Epstein–Barr Virus with Breast Cancer in Jordanian Women

Association between human telomerase reverse transcriptase (hTERT) MNS16A polymorphism and risk of breast cancer

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