Abstract:Telomere instability results from chromosome end loss due to chromosome breakage at one or both ends or, more frequently, telomere dysfunction. Dysfunctional telomeres arise when they lose their end-capping function or become critically short, which causes chromosomal termini to behave like a DN" double-strand break. "t the chromosomal level, this phenomenon is visualized by using Fluorescence In Situ Hybridization FISH , as chromosomal aberrations directly involving terminal telomeric repeats loss or duplicat… Show more
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