Telomere Length Alterations in Occupational Toxicants Exposure: An Integrated Review of the Literature

Ng, Chiat Yin; Amini, Farahnaz

doi:10.1007/s12403-020-00367-4

Cited by 10 publications

(3 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the results, TL can be affected in 603 different ways (decrease, increase or no effect), depending on e.g. the chemical contaminants studied, 604 the mode of exposure and the type of cells analysed (Louzon et al, 2019, Ng andAmini, 2020). For 605 example, exposure to PCBs and OCPs (as measured by their serum levels) was shown to impact 606 leukocyte TL in humans (Karimi et al, 2020), whereas non-dioxin-like PCBs and dioxin-like PCBs (except 607 for CB28) were related to increased TL; OCP exposure was related to telomere shortening.…”

Section: Telomere Length Can Vary Under the Influence Of Environmenta...mentioning

confidence: 99%

Development in the European flounder (Platichthys flesus) of a q-PCR assay for the measurement of telomere length, a potential biomarker of pollutant effects for biomonitoring studies

Akcha¹,

Cahuc²,

Rouxel³

et al. 2021

Marine Pollution Bulletin

View full text Add to dashboard Cite

Section: Telomere Length Can Vary Under the Influence Of Environmenta...mentioning

confidence: 99%

Development in the European flounder (Platichthys flesus) of a q-PCR assay for the measurement of telomere length, a potential biomarker of pollutant effects for biomonitoring studies

Akcha¹,

Cahuc²,

Rouxel³

et al. 2021

Marine Pollution Bulletin

View full text Add to dashboard Cite

“…Even the etiology of ASD is not well known, but a growing line of evidence proves that genetic components and their interaction with environmental factors contribute. Also, the impact of parents' unhealthy lifestyle and exposure to occupational and non-occupational environmental toxins on genome and epigenome integrity (Ng and Amini, 2020;Eshraghi et al, 2018;Wi sniowiecka-Kowalnik and Nowakowska, 2019;Kubota and Mochizuki, 2016), may contribute to ASD susceptibility. Current genetic information shows that genetic testing of chromosomal abnormalities in children with ASD can explain about 20% of cases, of which $7% are de novo mutations (Qiao et al, 2009;Geier et al, 2016;Abdul-Rahman and Hudgins, 2006;Gupta and State, 2007).…”

Section: Introductionmentioning

confidence: 99%

Awareness and perception of medical genetic services among Malaysian parents of autism spectrum disorders children: the lessons to be learned

Amini

Yee

Soh

et al. 2021

AIA

Self Cite

View full text Add to dashboard Cite

Purpose Autism spectrum disorder (ASD) is a group of complex neurodevelopmental disorders with uncertain etiology. Evidence shows that genetic testing can explain about 20% of cases. This study aims to assess the level of awareness and perception of medical genetic services among Malaysian parents with ASD children. Design/methodology/approach A cross-sectional survey using an interviewer-administered questionnaire was done among 111 parents of children with ASD from August 2017 to September 2019 in two clinics in Malaysia. Findings A majority of children with ASD (80.20%) were male and diagnosed at the age of 3–4 years old (47.80%). When the autistic child was born, most mothers and fathers were aged 26–30 (40.50%) and 31–35 years old (42.30%), respectively. Another child with ASD in nuclear and extended families was reported for 11.70% and 13.50%, respectively. Only 24.30% have seen a professional genetic consultant, and 19.8% have done genetic testing for affected children. The mean score of awareness of genetic services for ASD was 2.48 ± 3.30. Having medical insurance and another child with ASD in the nuclear family was significantly associated with a higher level of awareness (p = 0.01 and p < 0.001, respectively). Most of the participants have a positive perception of these services. Originality/value Regardless of demographic factors, participants have poor awareness of genetic services for ASD, likely because the primary physician did not recommend it upon diagnosis. Increasing health-care providers’ knowledge about the current potential of genetic testing for ASD and educational campaigns for the public are critical components of using available genetic tests to improve ASD management.

show abstract

“…Given the context that obese women experience more serious DNA damage, the incidence of micronutrient deficiency coupled with dietary intake of heavy metals synergistically lead to more significant DNA damage. Varying mechanisms causing genome instability have been reported among those occupationally exposed to heavy 29 . However, data regarding heavy metal exposure and its health consequences are not well established in non-occupational exposed groups.…”

Section: Introductionmentioning

confidence: 99%

Association of DNA damage with vitamin D and hair heavy metals of obese women

Amini

Bustami

et al. 2021

Mol. Cell. Toxicol.

Self Cite

View full text Add to dashboard Cite

Background: Obesity has been linked to DNA damage. The modifiable risk factors may modulate the impact of obesity on DNA damage. Objective: This study aimed to assess DNA damage and its association with dietary nutrient, serum 25-hydroxyvitamin D (25(OH)D) and concentration of hair heavy metals of obese and non-obese women. Method: A case-control study was conducted involving 134 women aged between 20 to 50 years. Serum 25(OH)D, fasting glucose, and lipid profile were assessed. Indicators of DNA damage such as percentage of tail DNA, tail moment, tail olive moment, tail intensity and tail length were measured using an alkaline-Comet assay.Concentrations of hair heavy metals were quantified using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Participants' daily energy, macro, and micronutrient intake were collected using the Food Frequency Questionnaire (FFQ). Results: Mean values of 25(OH)D was 31.8 ± 0.9 nmol/L. Majority of participants (96.3%) were 25(OH)D (<50 nmol/L) deficient. The mean BMI was 26.3 ± 0.5 kg/m 2 . Half of the participants (50.7%) have a high frequency of DNA strand breaks.Mean concentration of hair heavy metals (mg/kg) were 0.1 ± 0.03 (arsenic), 1.0 ± 0.4 (mercury), 2.8 ± 0.8 (lead), 0.2 ± 0.1 (cadmium) and 6.2 ± 0.4 (chromium). There was no significant difference for the mean of 25(OH)D, indicators of DNA damage, concentrations of hair heavy metals and dietary nutrients between obese and non-obese groups (p >0.05). Obese women with 25(OH)D level of ≥ 31nmol/L had a significantly lower tail moment (p=0.029) and tail olive moment (p=0.031); thus, indicating less DNA damage. Additionally, obese women with hair chromium concentration of ≥5.88 mg/kg had a significantly higher tail moment (p=0.047), indicating more DNA damage. Conclusion: DNA damage among obese women correlated with serum 25(OH)D and hair chromium.

show abstract

Telomere Length Alterations in Occupational Toxicants Exposure: An Integrated Review of the Literature

Cited by 10 publications

References 76 publications

Development in the European flounder (Platichthys flesus) of a q-PCR assay for the measurement of telomere length, a potential biomarker of pollutant effects for biomonitoring studies

Development in the European flounder (Platichthys flesus) of a q-PCR assay for the measurement of telomere length, a potential biomarker of pollutant effects for biomonitoring studies

Awareness and perception of medical genetic services among Malaysian parents of autism spectrum disorders children: the lessons to be learned

Association of DNA damage with vitamin D and hair heavy metals of obese women

Contact Info

Product

Resources

About