Telomere length and cardiovascular aging

Fyhrquist, Frej; Saijonmaa, Outi

doi:10.3109/07853890.2012.660497

Cited by 89 publications

(74 citation statements)

References 39 publications

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“…A previous study demonstrated that patients with CVD had shortening of total telomere length compared with healthy participants (21). Notably, previous reports have found that total telomere shortening per se causes cellular senescence in vascular endothelial cells (22) and eventually leads to atherosclerotic plaques (23). It raises the possibility that shortening of total telomere length directly involves pathologic conditions of CVD through cellular senescence.…”

Section: Discussionmentioning

confidence: 99%

Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients

Hirashio

Nakashima

Doi

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Telomeric G-tails play a pivotal role in maintaining the intramolecular loop structure of telomeres. Previous in vitro studies have suggested that the erosion of telomeric G-tails triggers cellular senescence, leading to organ dysfunction and atherosclerosis. The authors recently established a method to measure telomeric G-tail length using a hybridization protection assay. Using this method, this study investigated whether telomeric G-tail length could be used as a novel predictor for future cardiovascular events in hemodialysis patients.Design, setting, participants, & measurements A prospective observational study was performed involving a cohort of 203 Japanese hemodialysis patients to examine the lengths of telomeric G-tails and total telomeres and subsequent cardiovascular events during a median follow-up period of 48 months. The lengths of telomeric G-tails and total telomeres were also measured in 203 participants who did not have CKD and who were age-and sex-matched to hemodialysis patients. ResultsThe lengths of telomeric G-tails and total telomeres were significantly shorter in hemodialysis patients than in control subjects. Telomeric G-tails, but not total telomeres, were independently and negatively associated with clinical history of cardiovascular disease. During follow-up, 80 cardiovascular events occurred. Total telomere length did not predict cardiovascular events. However, the length of telomeric G-tails was associated with new-onset cardiovascular events (hazard ratio per log luminescence signals, 0.12; 95% confidence interval, 0.12 to 0.50) that persisted after adjustment for age, sex, diabetes mellitus, clinical history of cardiovascular disease, inflammation, use of vitamin D, and serum levels of phosphate and intact parathyroid hormone.Conclusions Longer telomeric G-tail length is associated with a lower risk of future cardiovascular events in hemodialysis patients.

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Section: Discussionmentioning

confidence: 99%

Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients

Hirashio

Nakashima

Doi

et al. 2014

Clinical Journal of the American Society of Nephrology

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“…Algunos agentes asociados con estilos de vida específicos (tabaco, adiposidad, estrés, exposición a la polución, dieta, sedentarismo) y al estrés oxidativo, infecciones, enfermedades crónicas e inflamación pueden acelerar el acortamiento de los telómeros, induciendo daños en el ADN o, más específicamente, en telómeros y afectando a la salud o la esperanza de vida del individuo (1,(30)(31)(32)(33)(34)(35)(36).…”

Section: Introductionunclassified

“…Los leucocitos son frecuentemente utilizados para medir la longitud del telómero porque se pueden obtener fácilmente mediante extracción sanguínea y reflejan perfectamente la tasa de acortamiento de las células somáticas (36,46). Sin embargo, no reflejan de manera adecuada el acortamiento de los telómeros en tejidos poco proliferantes como el cerebro, la grasa o el hígado (47).…”

Section: Introductionunclassified

“…Así pues, estos factores son los que están implicados con enfermedades de muy diferente espectro que están relacionadas con los telómeros (48)(49)(50). Entre estas enfermedades están las ligadas al envejecimiento: enfermedades de tipo cardiovascular (infarto de miocardio, enfermedad cerebrovascular, enfermedad arterial periférica) (27,36), cirrosis hepática, hipertensión, aterosclerosis, diabetes, cáncer y enfermedades neurodegenerativas (alzhéimer, párkinson) (14,(51)(52)(53)(54). La longitud de los telómeros predice la mortalidad y las enfermedades relacionadas con el envejecimiento (49).…”

Section: Introductionunclassified

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Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Marti¹,

Echeverría

Morell‐Azanza

et al. 2017

Nutr Hosp

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Palabras clave:Telómeros. Dieta mediterránea. Estrés oxidative. ADN. ResumenFundamento: existen pocos estudios que hayan evaluado la relación entre la calidad de la dieta y la integridad telómerica en humanos. Los telómeros son regiones de ADN no codificante que se encuentran en los extremos de los cromosomas, cuya longitud además de indicar la esperanza de vida, indica el estado global de salud. El objetivo de la presente revisión sistemática es recopilar la evidencia existente sobre la relación entre la longitud de los telómeros y la calidad de la dieta para conocer el impacto que algunos nutrientes, alimentos y patrones dietéticos pueden tener sobre la homeostasis telomérica y por lo tanto, sobre la salud en general. Material y métodos: se realizó una revisión bibliográfica en la base de datos PubMed para identificar los artículos publicados (en inglés o español) hasta diciembre de 2016 que cumplían los siguientes criterios: incluían sujetos humanos; eran estudios transversales; estudios de casos y controles; estudios de cohortes prospectivos o estudios de intervención; que evaluaban la relación de los nutrientes, alimentos o patrones dietéticos con la longitud de los telómeros. La estrategia de búsqueda incluía las siguientes palabras clave: nutrients or food OR food groups OR diet OR dietary pattern OR eating pattern OR dietary habits OR diet type AND telomere attrition OR telomere length. En total, se incluyeron 19 estudios transversales, cinco estudios de casos y controles, cinco estudios de cohortes prospectivos y dos estudios de intervención, incluyendo aquellos artículos que se encontraron por listas de referencias de otras publicaciones. Resultados: se encontraron asociaciones positivas entre la longitud de los telómeros y la adherencia a la dieta mediterránea y el consumo de verduras y frutas. Los resultados obtenidos para otros nutrientes, alimentos o patrones dietéticos fueron incoherentes, aunque parece que las carnes procesadas, los cereales, el alcohol y las bebidas endulzadas podrían estar asociados con telómeros más cortos. Conclusiones: la intervención dietética, y en particular la promoción de una dieta de estilo mediterráneo, podría desempeñar un papel en la protección de la integridad telomérica. Key words:Telomere. Mediterranean diet. Oxidative stress. DNA. AbstractBackground: Few studies have evaluated the relationship between diet quality and telomere integrity in humans. Telomeres are regions of non-coding DNA localized at the end of each chromosome whose length, in addition to indicating life expectancy, indicates an overall health status. The objective of this systematic review is to compile the existing evidence on the relationship between telomere length and diet quality to further explore the impact that some nutrients, foods and dietary patterns may have on telomere homeostasis and therefore, in precision nutrition strategies. Material and methods: A bibliographic review was performed in the PubMed database to identify published articles (in English or Spanish) until December 201...

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“…9,10 Particularly in CVD, which is the leading cause of death worldwide, short leukocyte telomeres have been associated with stroke, heart failure, atherosclerosis, and myocardial infarction. [10][11][12] Apart from CVD events, leukocyte telomere length (LTL) associates independently with CVD risk factors such as low density lipoproteins (LDL), male gender, and insulin resistance, suggesting TL's role in the development of CVD. 12,13 However, the utility of LTL as a potential marker for cardiovascular aging needs further validation due to inconsistent association of LTL with certain risk factors, such as body mass index (BMI) and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Association Between Leukocyte Telomere Length and Plasma Homocysteine in a Singapore Chinese Population

Rane

Koh

Kanchi

et al. 2015

Rejuvenation Research

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Rationale: Leukocyte telomere length (LTL) and plasma homocysteine (HCY) have been independently associated with cardiovascular disease (CVD) morbidity and mortality. However, few studies have investigated the association between LTL and HCY levels. Objective: This study investigated the association of LTL with CVD risk factors, including HCY, in an overt CVD-free Singapore Chinese population comprised of middle aged and elderly, the age group at risk of developing CVD. Approach: The association of plasma HCY and other CVD biomarkers with LTL were assessed in 100 samples drawn from the Singapore Chinese Health Study (SCHS). SCHS, a population-based cohort, recruited Chinese individuals, aged 45-74 years, between 1993 and 1998. Questionnaire data were collected via face-to-face interviews. Known CVD biomarkers were measured from the blood collected at the time of recruitment, and LTL was measured using the conventional Southern blot method. Results: After adjustment for age, gender, smoking status, education, and dialect, LTL was found to be inversely associated with plasma HCY levels ( p for trend = 0.014). Serum urate showed a weak association ( p for trend = 0.056). Other CVD risk factors and nutrients, namely total cholesterol, low-density lipoprotein (LDL), triglycerides and creatinine, high-density lipoprotein (HDL), folate, and vitamin B6 showed the expected trend with LTL, but did not reach statistical significance. Conclusion: LTL displayed an inverse association with plasma HCY. This LTL-HCY inverse association in subjects lacking obvious cardiovascular events suggests that telomere length may be an intermediary in the biological mechanism by which elevated HCY leads to CVD.

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Telomere length and cardiovascular aging

Cited by 89 publications

References 39 publications

Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients

Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Association Between Leukocyte Telomere Length and Plasma Homocysteine in a Singapore Chinese Population

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