Telomere length and telomerase activity in osteoporosis and osteoarthritis (Review)

Abstract

Osteoarthritis (OA) and osteoporosis (OP) are associated skeletal pathologies and have as a distinct feature the abnormal reconstruction of the subchondral bone. OA and OP have been characterized as age-related diseases and have been associated with telomere shortening and altered telomerase activity (TA). This review discusses the role of telomeres and telomerase in OA and OP pathologies and focuses on the usability of telomere length (TL) and the rate of telomere shortening as potential disease biomarkers. A number of studies have demonstrated that telomere shortening may contribute to OA and OP as an epigenetic factor. Therefore, it has been claimed that the measurement of TL of chondrocytes and/or peripheral blood cells may be an appropriate marker for the evaluation of the progression of these diseases. However, there is a need to be perform further studies with larger cohorts, with the aim of obtaining objective results and a better understanding of the association between TL, inflammation and aging, in order to provide further insight into the pathophysiology of degenerative joint diseases.

RETRACTED ARTICLE: A porous Co(II)–MOF for selective C2H2/CO2 separation and treatment activity on virus-induced COPD via reducing tlr3 gene expression

“…We have produced a Co(II)-MOF by reaction of Co(NO 3 ) 2 Á6H 2 O with 5-(3,5-di-pyridin-4yl- [1,2,4]triazol-1-ylmethyl)-isophthalic acid under solvothermal conditions. The structural determination study shows that 1 shows a twofold interpenetrated framework with three-dimensional pore channels covered with nitrogen-and oxygen-coordinated active positions.…”

“…All solvents and reagents used could be obtained from market and were utilized as the receptacles with no extra purification. The ligand 5-(3,5-di-pyridin-4-yl- [1,2,4]triazol-1-ylmethyl)-isophthalic acid was obtained from Shanghai Chemsoon Chemical Technology Co., Ltd. (Shanghai, China). The microanalyses analysis of carbon, hydrogen and nitrogen for the complex in novel samples was carried out using the elemental analyzer of Elementar Vario-EL CHN.…”

“…About 8% of hospitalized patients with community-acquired pneumonia are viral pneumonia. TLR3 is a kind of membrane receptor of alveolar macrophages, which could recognize the virus and then activate the following inflammatory signaling pathway, and release the inflammatory cytokines [3,4]. The accumulated inflammatory cytokines could further damage the lung tissue.…”

“…Moreover, in recent years, it has been shown that the establishment for the porous MOFs with bifunctional ligands is a feasible way to obtain the donor positions discordant MOFs [20][21][22]. In this research, a novel MOF containing Co(II) ions as nodes f[Co(L)]Á4H 2 OÁ2CH 3 CNg n (1) have been prepared via Co(NO 3 ) 2 Á6H 2 O reacting with the bifunctional ligand 5-(3,5-di-pyridin-4-yl- [1,2,4]triazol-1-ylmethyl)-isophthalic acid (H 2 L) under the solvothermal conditions (Scheme 1). The microporous MOF 1 which has the accessible alkaline sites was assessed for the separation of C 2 H 2 /CO 2 .…”

Ergosterol limits osteoarthritis development and progression through activation of Nrf2 signaling

“…Osteoarthritis (OA) is an aging-associated progressive joint disease characterized by cartilage loss and damage ( 1 , 2 ). However, to date, there is no effective and safe medication available against OA.…”