Telomere length as a biomarker of the risk of cardiovascular complications in patients with coronary heart disease

Doroshchuk, N. A.; Ланкин, В. З.; Tikhaze, A. K.; Kheimets, Grigory I.; Doroshсhuk, Alexander D.; Смирнова, М Д; Чазова, И Е

doi:10.26442/00403660.2021.01.200588

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Ashley et al found that there existed a certain relationship between HDL-C and telomere length [ 13 , 14 ]. A strong negative relationship between LDL and telomere length was reported in patients with cardiovascular complications in a case-investigation study [ 15 ]. Moreover, Alison et al discovered that shortening of telomere length in South Asian population with type 2 diabetes was inversely associated with TG and TC [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Persistent dyslipidemia increases the longitudinal changes in telomere length

Liu,

Ma,

Yang

et al. 2023

Lipids Health Dis

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Background and aims Leukocyte telomere length (LTL) as a ‘biological clock’ of aging is closely related to human health, its association with an aging-related disease, dyslipidemia, has been less studied and mainly focused on cross-sectional investigations. Methods Two rounds of information and blood collections were conducted on a cohort of 1624 individuals residing in rural Ningxia, located in northwest China, with an average time gap of 9.8 years. The relative telomere length (RTL) of peripheral blood leukocytes was assessed using real-time quantitative PCR. To investigate the association between dyslipidemia, blood lipid levels, and alterations in RTL, multiple linear regression and generalized linear models were employed. Results After conducting the follow-up analysis, it was observed that 83.3% of the participants in the study exhibited a reduction in telomere length, while 16.7% experienced an increase in telomere length. The results suggested that dyslipidemia at baseline or follow-up may increase longitudinal changes in telomere length, but it was more significant in the healthy group, especially in those aged ≥ 60 years. Furthermore, HDL-C levels in baseline and follow-up were found to be associated with longitudinal changes in telomere length, and lower HDL-C levels may be associated with increased longitudinal changes in telomere length. Conclusions The change in telomere length is correlated with dyslipidemia and its lipid indicators especially HDL-C. Persistent dyslipidemia and a reduction in HDL-C levels may be associated with elevated longitudinal fluctuations in telomere length.

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Section: Introductionmentioning

confidence: 99%

Persistent dyslipidemia increases the longitudinal changes in telomere length

Liu,

Ma,

Yang

et al. 2023

Lipids Health Dis

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Length of Leukocyte Telomeres in Newborns of HIV-Infected Mothers

et al. 2023

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Relationship Between Telomere Length and Markers of Inflammation in the Pre- And Postoperative Period of Patients With Coronary Artery Disease

Asanov,

Poddubnyak,

Ponasenko

2024

Kompleks. probl. serdečno-sosud. zabol.

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Highlights Telomere length in patients with coronary artery disease is shorter compared to the telomere length of healthy individuals.Telomeric regions of DNA in patients with coronary artery disease do not recover over time.Telomere length in atherogenesis negatively correlates with markers of cardiovascular diseases and inflammatory process. Aim. To assess the impact of changes in the length of telomeric regions of chromosomes on the course of coronary artery disease caused by coronary artery atherosclerosis in the population of residents of a coal-mining region.Methods. The study included 60 patients with coronary artery disease (before surgery and five years after) and 52 healthy participants. We isolated the DNA using the standard phenol-chloroform extraction method. We used the quantitative PCR method to measure the relative length of leukocyte telomeres and analyzed biochemical parameters using standard methods, selecting cytokine proteins as markers of the inflammatory process.Results. Telomeres in healthy participants were seven times longer compared to patients with coronary artery disease. At the same time, the length of telomeric regions of DNA did not differ in patients before surgery and after 5 years of rehabilitation. We used ROC analysis to determine the effectiveness of measuring telomeres as a marker of atherosclerosis. The area under the ROC curve was 0.998 ± 0.002. We found an inverse correlation between the telomere length and such parameters as the total body sodium, triglycerides and high-density lipoproteins. We noted a significant inverse correlation between such indicators of the lipid profile as triglycerides and high-density lipoproteins only in patients before surgery. The study results revealed direct and inverse dependence of the length of telomeres and cytokines such as IL-33 and IL-10, respectively.Conclusion. Supposedly, inflammatory processes and oxidative stress, complementing each other, are the causes of irreparable damage to telomeres, accelerating the aging process and leading to irreversible consequences in atherogenesis.

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Telomere length as a biomarker of the risk of cardiovascular complications in patients with coronary heart disease

Cited by 3 publications

References 19 publications

Persistent dyslipidemia increases the longitudinal changes in telomere length

Persistent dyslipidemia increases the longitudinal changes in telomere length

Length of Leukocyte Telomeres in Newborns of HIV-Infected Mothers

Relationship Between Telomere Length and Markers of Inflammation in the Pre- And Postoperative Period of Patients With Coronary Artery Disease

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