Telomere length elongation after weight loss intervention in obese adults

Carulli, Lucia; Anzivino, Claudia; Baldelli, Enrica; Zenobii, Mf; Rocchi, Marco; Bertolotti, Marco

doi:10.1016/j.ymgme.2016.04.003

Cited by 51 publications

(50 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…237 individuals were recruited (130 non-obese individuals 107 obese individuals). 93 of the 107 obese participants underwent bariatric surgery treatment [60]. Findings support the results of diet-induced interventions, reporting that the telomere length of obese participants was significantly shorter (p < 0.0001) [60].…”

Section: Resultsmentioning

confidence: 61%

“…However, they also saw significant methodological, clinical, and statistical heterogeneity between studies, which suggests that this association needs to be better defined and additional causative factors must be taken into account [59]. The effect of intentional weight loss on telomere length has been studied in two RCTs and two non-randomized intervention studies (table 3) [8,9,60,61]. …”

Section: Resultsmentioning

confidence: 99%

“…Formichi et al [60] have conducted the only surgery-induced non-randomized intervention study focusing on the patients' telomere length up to 12 months post-surgery. 237 individuals were recruited (130 non-obese individuals 107 obese individuals).…”

Section: Resultsmentioning

confidence: 99%

“…93 of the 107 obese participants underwent bariatric surgery treatment [60]. Findings support the results of diet-induced interventions, reporting that the telomere length of obese participants was significantly shorter (p < 0.0001) [60]. Moreover, the obese group has been divided into individuals with (n = 62) and without (n = 45) metabolic syndrome, and measurements showed that there was no difference in the telomere length between both groups [60].…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

2017

View full text Add to dashboard Cite

Background: Altered levels of markers of oxidative stress, DNA repair, and telomere integrity have been detected in obese individuals and may underlie the pathogenesis of obesity-related diseases. However, whether or not such effects are reversed by intentional weight loss has not been systematically reviewed. Methods: A literature search in PubMed/Medline identified 2,388 articles of which 21 studies (randomized controlled trial (RCT) (n = 10) and non-randomized intervention studies (n = 11)) were classified as testing the effects of intentional weight loss on i) oxidative stress (n = 15), ii) DNA repair (n = 2), and iii) telomere length (n = 4). Results: Across a broad range of intervention designs, diet-, exercise-, surgery-, balloon-induced weight loss regimens decreased oxidative stress measures. Studies investigating DNA repair capacity or telomere length as endpoints after weight loss were less common in number and yielded null or inconsistent results, respectively. Conclusion: While this systematic review supports a role for intentional weight loss in reducing obesity-associated oxidative stress, it is not clear whether the effects are primary outcomes or secondary to improvement in obesity-associated insulin resistance and/or chronic inflammation. Although the lack of effect of intentional weight loss on DNA repair capacity might be anticipated given that oxidative stress is reduced, additional studies are needed. The inconsistent effects of weight loss on telomere length or DNA repair suggest the need for a re-assessment of intervention designs and assay methodology to definitively address this topic.

show abstract

Section: Resultsmentioning

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

2017

View full text Add to dashboard Cite

show abstract

“…40 Telomere shortening could be another pathway to the establishment of a hematopoietic clone. The reduction of that risk may occur with weight loss.…”

mentioning

confidence: 99%

Obesity and neoplasms of lymphohematopoietic cells

Lichtman

2016

Blood Advances

View full text Add to dashboard Cite

Efficacy of a dietary supplement derived from five edible plants on telomere length in Thai adults: A randomized, double‐blind, placebo‐controlled trial

Praengam,

Tuntipopipat,

Muangnoi

et al. 2023

Food Science & Nutrition

View full text Add to dashboard Cite

Mylife/Mylife100® is a dietary supplement consisting of black sesame seed, guava fruit, mangosteen aril, pennywort leaves, and soy protein. These edible plants contain multiple high‐potential bioactive compounds exerting various vital biological functions including antioxidants which contribute to delaying the rate of telomere shortening. Telomere length is associated with cellular aging and age‐related diseases. This study aimed to assess the efficacy of Mylife/Mylife100® on telomere length through a randomized, double‐blind placebo‐controlled trial. The trial assessed the alteration of leukocyte telomere length after 32 adults aged 50–65 years received either Mylife/Mylife100® or placebo (five capsules/day) for 8‐week supplementation. The results demonstrated a significant increase in mean telomere length from baseline (6313 bp) to the 8‐week supplementation period (6655 bp; p < 0.05) in the group receiving the product, whereas no significant change was observed in the placebo group. Additionally, the product group exhibited a significant improvement in plasma total antioxidant capacity levels compared to the placebo group (mean change, +35 vs −38; p = 0.006). This study also showed a significant correlation between telomere length and % CD4 + T cells (r = +0.325; p = 0.00003), % CD8 + T cells (r = +0.156; p = 0.048), and visceral fat (r = − 0.349; p = 0.000006). The findings suggest that consuming this dietary supplement (Mylife/Mylife100®) for 8 weeks has a positive effect on cellular aging by lengthening telomeres possible through their antioxidant capacities. Oxidative stress and cellular aging are underlying predisease mechanisms that might be alleviated by supplementing with this product.

show abstract

Telomere length elongation after weight loss intervention in obese adults

Abstract: Our study shows that weight loss is associated to telomere lengthening in a positive correlation: the greater weight loss the greater telomere lengthening; moreover telomere lengthening is more significant in those subjects with shortest telomeres at baseline.

Cited by 51 publications

References 32 publications

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

Obesity and neoplasms of lymphohematopoietic cells

Efficacy of a dietary supplement derived from five edible plants on telomere length in Thai adults: A randomized, double‐blind, placebo‐controlled trial

Contact Info

Product

Resources

About