Telomere length in subjects with schizophrenia, their unaffected siblings and healthy controls: Evidence of accelerated aging

Czepielewski, Letícia Sanguinetti; Massuda, Raffael; Panizzutti, Bruna; Rosa, Eduarda Dias da; Lucena, David Freitas de; Macêdo, Danielle Silveira; Grün, Lucas Kich; Barbé-Tuana, Florencia Marı́a; Gama, Clarissa Severino

doi:10.1016/j.schres.2016.04.004

Cited by 38 publications

(16 citation statements)

References 28 publications

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“…Consistent with previous meta-analyses, 17,19 findings were mixed. Five reports found that TL and telomerase activity were decreased in schizophrenia, 29,34,36,42,49 3 observed no difference in TL between schizophrenia and HC groups, 31,32,51 and one reported increased TL in schizophrenia. 33 Wolkowitz et al 47 found a group × gender interaction, such that HC women had longer TL than women with schizophrenia.…”

Section: Characteristics Of Reviewed Studiesmentioning

confidence: 95%

“…Five reports found no relationship between age and TL 29,31,32,51 or telomerase activity, 36 while 4 observed negative correlations between age and TL in both schizophrenia and comparison groups. 33,34,47,49 None of these studies statistically examined group differences in age-relationships. Two studies investigated an age × group interaction.…”

Section: Characteristics Of Reviewed Studiesmentioning

confidence: 99%

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Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions

Nguyen

Eyler

Jeste

2017

Schizophrenia Bulletin

105

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Background: Schizophrenia is associated with increased physical morbidity and early mortality, suggesting that the aging process may be accelerated in schizophrenia. However, the biological underpinnings of these alterations in aging in schizophrenia are unclear. Method: We conducted a detailed search of peer-reviewed empirical studies to evaluate evidence for accelerated biological aging in schizophrenia based on systemic, age-related biomarkers. We included studies that investigated differences between persons with schizophrenia and healthy comparison subjects in levels of biomarkers known to be associated with aging and examined the relationship of these biomarkers to age in the 2 groups. Results: Forty-two articles that met our selection criteria were reviewed. Nearly 75% reported abnormal biomarker levels among individuals with schizophrenia, including indices of inflammation, cytotoxicity, oxidative stress, metabolic health, gene expression, and receptor/synaptic function, with medium to large effect sizes reported in many studies. Twenty-nine percent of the studies observed differential age-related decline in schizophrenia. Markers of receptor/synaptic function and gene expression were most frequently differentially related to age in schizophrenia. Schizophrenia patients with greater disease severity and longer illness duration exhibited higher levels of inflammatory and oxidative stress biomarkers and shorter telomere length. Conclusions: Most studies show biomarker abnormalities in schizophrenia, and there is some suggestion for accelerated aging. Although definitive interpretation is limited by cross-sectional design of the published reports, findings in the area of gene expression and synaptic function are promising and pave the way for future longitudinal studies needed to fully test this hypothesis.

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Section: Characteristics Of Reviewed Studiesmentioning

confidence: 95%

Section: Characteristics Of Reviewed Studiesmentioning

confidence: 99%

Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions

Nguyen

Eyler

Jeste

2017

Schizophrenia Bulletin

105

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“…Schizophrenia is a complex neurodevelopmental disorder characterized by mental dysfunction in multiple domains of the brain ( 46 ). Previous studies have shown lower telomere length in patients with schizophrenia and paranoid schizophrenia compared to control groups ( 47 , 48 ).…”

Section: Schizophreniamentioning

confidence: 99%

Common mental disorders and association with telomere length (Review)

et al. 2018

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Telomeres are repeated 5′-TTAGGG-3′ sequences at the end of chromosomes, which maintain genomic stability. Their length is related to a number of diseases that affect humans. Apart from cancer, cardiovascular diseases, diabetes and other, telomere length has been associated with chronic diseases. Chronic mental illness includes various types of mental disorders with the most common being depression, schizophrenia and stress-anxiety. The aim of this review is to summarize the current state of knowledge on the role of telomeres in these disorders and to compare telomere length variations in patients receiving medication and patients not taking treatment. Most studies report reduced telomere length in patients suffering from mental disorders, compared to the general population. Since the factors that can affect telomere length are various, more experiments and investigations are required to understand the general impact of different factors on telomere length.

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“…In previous experiments, we also used synthetic oligos previously published for the generation of the standard curves for the amplification of the telomeres’ sequence for telomeres or the RPLPO gene with the same results ( O’Callaghan et al, 2008 ). We have already published 2 studies with these conditions ( Barbé-Tuana et al, 2016 ; Czepielewski et al, 2016 ).…”

Section: Bdnf Analysismentioning

confidence: 99%

Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging

Vasconcelos-Moreno

Fries

Gubert

et al. 2017

International Journal of Neuropsychopharmacology

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Background:Growing evidence supports the existence of neurobiological trait abnormalities in individuals at genetic risk for bipolar disorder. The aim of this study was to examine potential differences in brain-derived neurotrophic factor, cytokines, oxidative stress, and telomere length markers between patients with bipolar disorder, their siblings, and healthy controls.Methods:Thirty-six patients with bipolar disorder type I, 39 siblings, and 44 healthy controls were assessed. Serum levels of brain-derived neurotrophic factor, interleukin-6, interleukin-10, tumor necrosis factor-α, C-C motif chemokine 11, C-C motif chemokine 24, and 3-nitrotyrosine were measured, as were the activities of glutathione peroxidase, glutathione reductase, and glutathione S-transferase. Telomere length (T/S ratio) was measured using quantitative polymerase chain reaction.Results:Telomere length was different between the 3 groups (P = .041) with both patients and siblings showing a shorter T/S ratio compared with healthy controls. Patients showed increased levels of interleukin-6 (P = .005) and interleukin-10 (P = .002) compared with controls as well as increased levels of interleukin-6 (p = 0.014) and CCL24 (P = .016) compared with their siblings. C-C motif chemokine 11 levels were increased in siblings compared with controls (P = .015), and a similar tendency was found in patients compared with controls (P = .045). Glutathione peroxidase activity was decreased in patients compared with controls (P = .006) and siblings (P = .025). No differences were found for the other markers.Conclusions:The present results suggest that unaffected siblings may present accelerated aging features. These neurobiological findings may be considered as endophenotypic traits. Further prospective studies are warranted.

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Telomere length in subjects with schizophrenia, their unaffected siblings and healthy controls: Evidence of accelerated aging

Cited by 38 publications

References 28 publications

Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions

Systemic Biomarkers of Accelerated Aging in Schizophrenia: A Critical Review and Future Directions

Common mental disorders and association with telomere length (Review)

Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging

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