TEM analysis of apatite surface layers observed on zinc based glass polyalkenoate cements

Boyd, Daniel; Towler, Mark R.; Wren, A.W.; Clarkin, Owen; Tanner, David A.

doi:10.1007/s10853-007-2362-7

Cited by 21 publications

(17 citation statements)

References 20 publications

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“…Similar trends have been reported for incubated bioactive glasses . The observed increase in the intensity of the Ca, P, and Zn peaks in the EDS spectra can be seen as an indication of formation of CaP layer, where Ca seems to be partially replaced by Zn; this partial replacement of Ca with Zn has been previously reported for other bioactive glasses with Zn in their composition . Further analyses such as FTIR and XRD can provide more information about the chemical composition and crystallinity of the observed precipitations.…”

Section: Resultssupporting

confidence: 85%

The impact of gallium content on degradation, bioactivity, and antibacterial potency of zinc borate bioactive glass

et al. 2017

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Zinc borate glasses with increasing gallium content (0, 2.5, 5, 10, and 15 Wt % Ga) were synthesized and their degradation, bioactivity in simulated body fluid (SBF), and antibacterial properties were investigated. ICP measurements showed that increased gallium content in the glass resulted in increased gallium ion release and decreased release of other ions. Degradability declined with the addition of gallium, indicating the formation of more symmetric BO 3 units with three bridging oxygens and asymmetric BO 3 units with two bridging oxygens in the glass network as the gallium content in the series increased. The formation of amorphous CaAP on the glass surface after 24 h of incubation in SBF was confirmed by SEM, XRD, and FTIR analyses. Finally, antibacterial evaluation of the glasses using the agar discdiffusion method demonstrated that the addition of gallium increased the antibacterial potency of the glasses against P. aeruginosa (Gram-negative) while decreasing it against S. epidermidis (Gram-positive); considering the ion release trends, this indicates that the gallium ion is responsible for the glasses' antibacterial behavior against P. aeruginosa while the zinc ion controls the antibacterial activity against S. epidermidis. The statistical significance of the observed trends in the measurements were confirmed by applying the Kruskal-Wallis H Test.

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Section: Resultssupporting

confidence: 85%

The impact of gallium content on degradation, bioactivity, and antibacterial potency of zinc borate bioactive glass

et al. 2017

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“…The soluble silica content forms the negatively charged Si-OH -groups on the surface of the material [39,40] . It is also evident that there is a high concentration of Zn 2+ released from the cement which has previously been found to inhibit the crystallization of this surface layer to hydroxyapatite (HA) [41] . SBF testing revealed that surface precipitation of CaP was present on each of the cements at each time period.…”

Section: Resultsmentioning

confidence: 99%

The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications

Wren

Cummins

Laffir

et al. 2010

J Mater Sci: Mater Med

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The ion release profiles and bioactivity of a series of Ti containing glass polyalkenoate cements (GPCs). Characterization revealed each material to be amorphous with a T g in the region of 650-660ºC. The network connectivity decreased (1.83-1.35) with the addition of TiO 2 which was also evident with analysis by X-ray Photoelectron Spectroscopy (XPS). Ion release from cements were determined using Atomic Absorption Spectroscopy (AAS) for zinc (

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“…In addition, Ga increases the Lewis acidic strength of bioglass, which makes them suitable for interaction with biomolecules such as proteins and drugs [37]. Furthermore, Zn has been known to enhance bone regeneration and retard the transformation of amorphous hydroxyl carbonate apatite to crystalline HA which is comparable to the biological formation of HA in vivo [55].…”

Section: Indirect Immunostainingmentioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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Bone can be affected by osteosarcomae requiring surgical excision of the tumor as part of the treatment regime. Complete removal of cancerous cells is difficult and conventionally requires the removal of a margin of safety around the tumor to offer improved patient prognosis. This work considers a novel series of composite scaffolds based on poly(octanediol citrate) (POC) impregnated with galliumbased bioglass microparticles for possible incorporation into bone following tumor removal. The objective of this research was to fabricate and characterize these scaffolds and subsequently report on their mechanical and biological properties. The porous microcomposite scaffolds with various concentrations of bioglass (10, 20, 30 wt%) incorporated were fabricated using a salt leaching technique. The scaffolds exhibited compression modulus in the range of 0.3-7 MPa. The addition of bioglass increased the mechanical properties even though porosity increased. Furthermore, increasing the concentration of bioglass had a significant influence on glass transition temperature from 2.5°C for the pure polymer to around 25°C for 30 % bioglass-containing composite. The ion release study revealed that composites containing 10 % bioglass had the highest ion release ratio after 28 days of soaking in phosphate buffered saline. The interaction of bioglass phase with POC led to the formation of additional ionic crosslinks aside from covalent crosslinks which further resulted in increased stiffness and decreased weight loss. The osteoblast cells were well attached and growth on composites and collagen synthesis increased particularly with the 10 % bioglass concentration.

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TEM analysis of apatite surface layers observed on zinc based glass polyalkenoate cements

Cited by 21 publications

References 20 publications

The impact of gallium content on degradation, bioactivity, and antibacterial potency of zinc borate bioactive glass

The impact of gallium content on degradation, bioactivity, and antibacterial potency of zinc borate bioactive glass

The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

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