Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells

Yang, Zhikuan; Wei, Dongbin; Liu, Fei-Fei; Liu, Jing; Wu, Xiaoming; Stevens, Malcolm F. G.; Bradshaw, Tracey D.; Luo, Ying; Zhang, Jihong

doi:10.1002/jcb.26674

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…None of the chemotherapy agents typically used as part of LCRT or TNT are true directly alkylating agents. It is possible that any substantially increased benefit for MGMTh patients from the addition of Temozolomide or other direct alkylating agents may be in the definitive setting combined with newer therapies [49] , [50] .…”

Section: Discussionmentioning

confidence: 99%

Improved Pathologic response to chemoradiation in MGMT methylated locally advanced rectal cancer

Jensen

Pourfarrokh²,

Volz³

et al. 2023

Clinical and Translational Radiation Oncology

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Section: Discussionmentioning

confidence: 99%

Improved Pathologic response to chemoradiation in MGMT methylated locally advanced rectal cancer

Jensen

Pourfarrokh²,

Volz³

et al. 2023

Clinical and Translational Radiation Oncology

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“…However, oxaliplatin treatment had less inhibitory effect in mice bearing HCT116 tumor cells (Figure S2A-C). Several studies have shown that HCT116 is an MMR-deficient cell line while SW480 is an MMR-proficient cell line, and that loss of MMR leads to increased adaptive variability and chemoresistance in CRC [10,[16][17][18]. Therefore, we detected the protein and mRNA expression of functional proteins in MMR.…”

Section: Mmr Is Inhibited In C Tropicalis-induced Crc Chemotherapy Resistancementioning

confidence: 99%

C. tropicalis promotes chemotherapy resistance in colon cancer through increasing lactate production to regulate the mismatch repair system

Sun

Chen

et al. 2021

Int. J. Biol. Sci.

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Due to chemotherapeutic drug resistance, tumor recurrence is common in patients with colorectal cancer (CRC) and chemo-resistant patients are often accompanied by defects in the mismatch repair system (MMR). Our previous study has shown that Candida tropicalis (C. tropicalis) is closely related to the occurrence and development of colorectal cancer, but whether this conditional pathogenic fungus is involved in chemotherapy needs further investigation. Here we found that C. tropicalis promoted chemotherapy resistance of colon cancer to oxaliplatin. Compared with oxaliplatin-treated group, the expression of functional MMR proteins in tumors were decreased in C.tropicalis/oxaliplatin -treated group, while the glycolysis level of tumors was up-regulated and the production of lactate was significantly increased in C.tropicalis/oxaliplatin -treated group. Inhibiting lactate production significantly alleviated the chemoresistance and rescued the decreased expression of MMR caused by C. tropicalis. Furthermore, we found that lactate down-regulated the expression of MLH1 through the GPR81-cAMP-PKA-CREB axis. This study clarified that C. tropicalis promoted chemoresistance of colon cancer via producing lactate and inhibiting the expression of MLH1, which may provide novel ideas for improving CRC chemotherapy effect.

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The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis

Zhang

Ren

et al. 2021

BMC Cancer

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Background In recent years, emerging studies have demonstrated critical functions and potential clinical applications of long non-coding RNA (lncRNA) in osteosarcoma. To further validate the prognostic value of multiple lncRNAs, we have conducted this updated meta-analysis. Methods Literature retrieval was conducted by searching PubMed, Web of Science and the Cochrane Library (last update by October 2, 2019). A meta-analysis was performed to explore association between lncRNAs expression and overall survival (OS) of osteosarcoma patients. Relationships between lncRNAs expression and other clinicopathological features were also analyzed respectively. Results Overall, 4351 patients from 62 studies were included in this meta-analysis and 25 lncRNAs were identified. Pooled analyses showed that high expression of 14 lncRNAs connoted worse OS, while two lncRNAs were associated with positive outcome. Further, analysis toward osteosarcoma clinicopathologic features demonstrated that overexpression of TUG1 and XIST indicated poor clinical parameters of patients. Conclusions This meta-analysis has elucidated the prognostic potential of 16 lncRNAs in human osteosarcoma. Evidently, desperate expression and functional targets of these lncRNAs offer new approaches for prognosis and therapy of osteosarcoma.

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Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells

Cited by 4 publications

References 19 publications

Improved Pathologic response to chemoradiation in MGMT methylated locally advanced rectal cancer

Improved Pathologic response to chemoradiation in MGMT methylated locally advanced rectal cancer

C. tropicalis promotes chemotherapy resistance in colon cancer through increasing lactate production to regulate the mismatch repair system

The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis

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