Temozolomide loaded nano lipid based chitosan hydrogel for nose to brain delivery: Characterization, nasal absorption, histopathology and cell line study

Khan, Anam; Aqil, Mohd.; Imam, Syed Sarim; Ahad, Abdul; Sultana, Yasmin; Ali, Asgar; Khan, Khalid Mohammed

doi:10.1016/j.ijbiomac.2018.05.079

Cited by 88 publications

(38 citation statements)

References 41 publications

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“…Previous findings [78,79], agreed that chitosan coated nanoparticles increased the drug permeation across the nasal mucosa compared to the free drug control. This controlled SVT permeation, together with mucoadhesion effect, may be an important strategy to prolong the effect of the drug when administered via the nasal route.…”

Section: Discussionsupporting

confidence: 66%

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

Bruinsmann¹,

Pigana²,

Aguirre³

et al. 2019

Preprint

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Drug delivery to the brain represents a challenge especially in the therapy of central nervous system malignancies. Simvastatin (SVT), as other statins, has shown potential anticancer properties that are difficult to exploit in the CNS. In the present work the physico-chemical, mucoadhesive and permeability enhancing properties of simvastatin-loaded poly-ε-caprolactone nanocapsules coated with chitosan for nose-to-brain administration were investigated. Lipid-core nanocapsules coated with different molecular weight (MW) chitosans (LNCchit) prepared by a novel one-pot technique were characterized for particle size, surface charge, particle number density, morphology, drug encapsulation efficiency, interaction between surface nanocapsules with mucin, drug release and permeability across two nasal mucosa models. Results show that all formulations present adequate particle size (below 220 nm), positive surface charge, narrow droplet size distribution (PDI<0.2) and high encapsulation efficiency. Nanocapsules presented controlled drug release and mucoadhesive properties dependent on the MW of the coating chitosan. The results of permeation across RPMI 2650 human nasal cell line evidenced that LNCchit increased the permeation of SVT. In particular, the amount of SVT permeated after 4h for nanocapsules coated with low MW chitosan, high MW chitosan and control SVT was 13.91 ± 0.78 µg, 9.15 ± 1.23 µg and 1.42 ± 0.21 µg respectively. These results were confirmed by the SVT ex vivo permeation across rabbit nasal mucosa. This study highlighted the suitability of LNCchit as promising strategy for the administration of simvastatin for a nose-to-brain approach for the therapy of brain tumors.

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Section: Discussionsupporting

confidence: 66%

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

Bruinsmann¹,

Pigana²,

Aguirre³

et al. 2019

Preprint

View full text Add to dashboard Cite

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“…However, as previously mentioned, different properties of the nanocarrier are determining factors to go through BBB, and the neutral charge of lipid nanosystems is a limitation. For this reason, SLN made of behenic acid [94] and Vit E:gelucire 44/14 [95] were decorated with chitosan to get a cationic nanocarrier and enhance the BBB permeation of paclitaxel and temozolomide, respectively. Both formulations presented increased cytotoxicity, which was explained by the increased permeability through the BBB monolayer compared to free drug, as well as an increase in viscosity and residence time of the system in the nasal region.…”

Section: Lipid Nanoparticlesmentioning

confidence: 99%

A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier

et al. 2020

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The blood-brain barrier (BBB) is a sophisticated and very selective dynamic interface composed of endothelial cells expressing enzymes, transport systems, and receptors that regulate the passage of nutrients, ions, oxygen, and other essential molecules to the brain, regulating its homeostasis. Moreover, the BBB performs a vital function in protecting the brain from pathogens and other dangerous agents in the blood circulation. Despite its crucial role, this barrier represents a difficult obstacle for the treatment of brain diseases because many therapeutic agents cannot cross it. Thus, different strategies based on nanoparticles have been explored in recent years. Concerning this, chitosan-decorated nanoparticles have demonstrated enormous potential for drug delivery across the BBB and treatment of Alzheimer’s disease, Parkinson’s disease, gliomas, cerebral ischemia, and schizophrenia. Our main objective was to highlight the high potential of chitosan adsorption to improve the penetrability through the BBB of nanoformulations for diseases of CNS. Therefore, we describe the BBB structure and function, as well as the routes of chitosan for crossing it. Moreover, we define the methods of decoration of nanoparticles with chitosan and provide numerous examples of their potential utilization in a variety of brain diseases. Lastly, we discuss future directions, mentioning the need for extensive characterization of proposed nanoformulations and clinical trials for evaluation of their efficacy.

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“…Chitosan-based biomaterials have become a popular target in the development of tissue engineering and significant progress has recently been made. It provides certain mechanical and structural properties for proper functioning for the repaired tissues (Khan et al, 2018;Fiqrianti et al, 2018;Sun, Lee, Zhang, 2018).…”

Section: Stability Studiesmentioning

confidence: 99%

Targeting of temozolomide using magnetic nanobeads: an in vitro study

Gurten

Yenigül

Sezer

et al. 2020

Braz. J. Pharm. Sci.

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Temozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug was encapsulated within the hydrophobic cavities of b-CD modified magnetite nanoparticles, which are embedded in chitosan nanobeads prepared by salt addition. In-vitro studies have shown that the magnetic properties of the novel delivery vehicle are adequate for targeted drug delivery applications under an external magnetic field. Additionally, an increase in the amount of chitosan was shown to exhibit a strong shielding effect over the magnetic properties of the delivery vehicle, which lead to deterioration of the amount of captured drug at the targeted area, suggesting a delicate balance between the amounts of constituents composing the drug delivery vehicle.

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Temozolomide loaded nano lipid based chitosan hydrogel for nose to brain delivery: Characterization, nasal absorption, histopathology and cell line study

Cited by 88 publications

References 41 publications

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier

Targeting of temozolomide using magnetic nanobeads: an in vitro study

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