Temperature control in large-internal-diameter scaffolded monolithic columns operated at ultra-high pressures

Core–Shell, Ultrasmall Particles, Monoliths, and Other Support Materials in High-Performance Liquid Chromatography

“…The peak capacity obtainable with a polymer monolithic column of conventional size was shown to be smaller than that with silica core–shell particulate or monolithic column in protein digest analysis . Research on high-efficiency polymer monolithic columns has been carried out in a capillary format in most cases; however, the application of metal-scaffolded columns may enable the preparation and application of conventional-size high-efficiency polymer monolithic columns under high pressure …”

Towards spatial comprehensive three-dimensional liquid chromatography: A tutorial review

“…These problems can be overcome by using a scaffold, albeit at the expense of available separation space, as used by Vonk et al who developed a titanium-scaffolded polymermonolithic structure compatible with UHPLC gradient operation in 4 mm i.d. column formats [75,76].…”

Are we approaching a post‐monolithic era?

“…Even multistep preparation of polymer‐based monolithic stationary phases combining a radical polymerization and postpolymerization hypercross‐linking modification provides batch‐to‐batch retention time deviations <2.7% [12]. Additionally, an effect of the heating device controlling thermally initiated polymerization [13], applied photoinitiator [14], and id [15] on the repeatability of preparation has been studied to confirm robust preparation of polymer monoliths.…”