Temperature Dependence of the Colloidal Stability of Neutral Amphiphilic Polymers in Water

Aseyev, Vladimir; Tenhu, Heikki; Winnik, Françoise M.

doi:10.1007/12_052

Cited by 223 publications

(145 citation statements)

References 307 publications

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“…Occurrence of hysteresis was explained by the presence of intra-or interchain hydrogen bonds that are broken during cooling. [23,25] Our light scattering experiments prove that the synthesized thermosensitive polyoxazolines have similar features to the thermosensitive polymers described above. We have completed a basic characterization in water to make the system as principally transparent as possible.…”

Section: Temperature-responsive Aggregation Behaviormentioning

confidence: 50%

“…A detailed review of the properties of temperature-sensitive polymers, including light scattering studies, has been published. [23] Recently, light and neutron scattering methods were exploited extensively for the investigation of these polymers, e.g., of poly(N-isopropylacrylamide) [24,25] (PNIPAM), poly(N-vinyl caprolactam) [24,26] (PVCL), poly(methyl vinyl ether) [24] (PVME), hydrophobically modified poly(N-isopropylacrylamide) (HM-PNI-PAM) [27][28][29][30][31] or of hydrophobically modified polyoxazolines. [32][33][34] Several scenarios for the structural transition in a solution during phase separation could come to life, depending on the chemical composition and concentration of the thermoresponsive polymer.…”

Section: Temperature-responsive Aggregation Behaviormentioning

confidence: 99%

“…Such behavior is in agreement with previous observations for thermoresponsive polymers reported in the literature. [23] It is reasonable to assume that due to the smallest content of hydrophilic MeOX groups in the macromolecular structure, the thermosensitive IprOX block have control over behavior of the aggregates above the CPT. A very important property of micelles designed for drug delivery purposes is their critical micellar concentration (CMC).…”

Section: Temperature-responsive Aggregation Behaviormentioning

confidence: 99%

See 2 more Smart Citations

Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems

Hrubý

Filippov

Pánek

et al. 2010

Macromolecular Bioscience

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Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5-10 × 10(-5) g · mL(-1) with diameter ≈200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine-125 ongoing in good yield with sufficient in vitro stability under model conditions.

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Section: Temperature-responsive Aggregation Behaviormentioning

confidence: 50%

Section: Temperature-responsive Aggregation Behaviormentioning

confidence: 99%

Section: Temperature-responsive Aggregation Behaviormentioning

confidence: 99%

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Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems

Hrubý

Filippov

Pánek

et al. 2010

Macromolecular Bioscience

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“…Homopolymer poly(NIPAM) and other AM-based polymers which are amphiphilic in nature, exhibits LCST in aqueous solutions. These polymers swell at the lowest temperatures, whereas heating above LCST causes contraction due to expelling of water [46][47][48]. Abrupt macromolecular transition in poly(NIPAM) from hydrophilic to hydrophobic structure occurs as a consequence of LCST [47].…”

Section: Introductionmentioning

confidence: 99%

Hydrogels based on N-isopropylmethacrylamide and N-isopropylacrylamide

Urošević¹,

Nikolić²,

Ilić‐Stojanović³

et al. 2018

Adv Techol

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Hydrogels are three-dimensional polymer networks which have the capacity to retain a large quantity of water or biological fluids in the swollen state. Thermosensitive hydrogels have received special attention of reserachers since they represent a parameter which frequently changes in chemical, biological and physiological systems. Thermosensitive hydrogels have the critical solution temperature, i.e. they exhibit a substantial change in volume with the temperature change. Homopolymers poly(N-isopropylmethacrylamide) (poly(NIPMAM)) and poly(N-isopropylacrylamide) (poly(NIPAM)) are thermosensitive materials which have lately become the subject of intensive study. Monomer N-isopropylmethacrylamide, NIPMAM, enters into copolymerization with monomer N-isopropylacrylamide, NIPAM, in order to create a system with a phase transition temperature approximate to the human body temperature. In literature data there is available information on the synthesis and characterization of microgels, nanogels and copolymers based on NIPMAM and NIPAM. These thermosensitive polymer materials are used in controlled drug delivery and protein immobilization.

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“…The ability of the polymers to change their behavior according to external conditions, and the possibility to moderate this effect, make such systems interesting for drug delivery applications, as sensors, and in cosmetics [1][2][3][4]. Investigations of the transition phenomena in model systems can offer knowledge that is of practical use.…”

Section: Introductionmentioning

confidence: 99%

Additive Effects on Phase Transition and Interactions in Poly(vinyl methyl ether) Solutions

et al. 2015

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Abstract:A comparative study of thermal response of poly (vinyl methyl ether) in the presence of different hydrophilic and hydrophobic additives was performed by Nuclear magnetic resonance (NMR) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and optical microscopy. The effect of polymer concentration and additive content on the appearance and extent of the phase transition was determined. A detailed study of interaction mechanism in solutions with two hydrophobic additives showed differences in the way in which polymer globules are formed. For solutions containing t-butyl methyl ketone and t-butanol, measurements of 1 H spin-spin relaxations showed the presence of water and additive molecules bound in PVME globular structures. These originally-bound molecules are then slowly released from the globular-like structures. Incorporation of molecules into the globules disrupts the cooperativity of the transition and affects the size of globular structures.

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Temperature Dependence of the Colloidal Stability of Neutral Amphiphilic Polymers in Water

Cited by 223 publications

References 307 publications

Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems

Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems

Hydrogels based on N-isopropylmethacrylamide and N-isopropylacrylamide

Additive Effects on Phase Transition and Interactions in Poly(vinyl methyl ether) Solutions

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