Temperature Feedback‐Controlled Photothermal/Photodynamic/Chemodynamic Combination Cancer Therapy Based on NaGdF₄:Er,Yb@NaGdF₄:Nd@Cu‐BIF Nanoassemblies

Abstract

The intelligent design of multifunctional nanoplatforms is critical for cancer therapy. Herein, NaGdF 4 :Er,Yb@NaGdF 4 :Nd@Cu(II) boron−imidazolate frameworks (denoted as CSNPs@Cu-BIF) nanoassemblies are designed and fabricated. Upon a single 808 nm laser irradiation, the nanoassemblies not only show the outstanding photothermal conversion capacity (= 41.7%) but also generate cytotoxic reactive oxygen species through an in situ Fenton-like reaction and fluorescence resonance energy transfer. Importantly, the nanoassemblies simultaneously introduce remarkable antitumor efficacy via photothermal/photodynamic/chemodynamic combination therapy both in vitro and in vivo. To improve the therapeutic effect of solid tumor ablation, it is highly desirable to monitor the treatment process in real-time. Multiclinical imaging modalities of ultrasonography are employed to systematically investigate the ablation mechanism of solid tumors in vivo. Furthermore, the significant difference between the eigen temperature of CSNPs@Cu-BIF nanoassemblies obtained by the temperature-sensitive emission bands signal changes and the apparent temperature recorded by the thermal imaging camera is 14.55 K at equilibrium. This current work therefore supplies an alternative strategy in temperature feedback-controlled accurate cancer therapy.

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

“…There are some examples of using Cu‐containing nanomaterials for CDT‐involved multimodal therapy, [ 253–270 ] some of which are listed in Table 2. For example, Cu‐based CDT together with other therapies can enhance cancer immunotherapy.…”

Enhanced Chemoradiotherapy for MRSA‐Infected Osteomyelitis Using Immunomodulatory Polymer‐Reinforced Nanotherapeutics

“…The presence of the other dioxide, O 2 −• , was further verified using nitro‐blue tetrazolium (NBT), which exhibited a maximum absorption wavelength of 260 nm. [ 43 ] The absorbance of NBT was reduced in both X‐ray irradiation groups, especially in the SNP + X‐ray group, thus indicating high O 2 −• production by SNP under X‐ray irradiation (Figure 2e). These results indicated that SNP promoted the production of O 2 −• in radiotherapy because it has a strong X‐ray absorption capacity and reacts with the surrounding O 2 and water.…”

Polydopamine-Modified Zeolite Imidazole Framework Drug Delivery System for Photothermal Chemotherapy of Hepatocellular Carcinoma

“…As emerging class of hybrid porous materials constructed from metal nodes and organic linkers, metal organic frameworks (MOFs) gain numerous attentions in recent years and widely applicated in catalysis, gas separation and conversion, chemical sensors, and biomedicine. , With the intrinsic characteristics of large surface areas and highly ordered porosities, MOFs exhibit potent capability of loading and releasing different therapeutic cargoes. − Zeolitic imidazolate frameworks (ZIF-8) as a new porous material consist of zinc ions and 2-methylimidazole, which endow it with pH responsiveness, size controllable adjustment, and comparable compatibility. As an excellent drug carrier, cargoes can be easily encapsulated on the surface or center of ZIF-8 via multiple interactions such as electrostatic adsorption, coordination, and π–π stacking .…”