Temperature‐mediated diffusion of nanoparticles in semidilute polymer solutions

Abstract

The temperature is often a critical factor affecting the diffusion of nanoparticles in complex physiological media, but its specific effects are still to be fully understood. Here, we constructed a temperature‐regulated model of semidilute polymer solution and experimentally investigated the temperature‐mediated diffusion of nanoparticles using the particle tracking method. By examining the ensemble‐averaged mean square displacements (MSDs), we found that the MSD grows gradually as the temperature increases while the transition time from sublinear to linear stage in MSD decreases. Meanwhile, the temperature‐dependent measured diffusivity of the nanoparticles shows an exponential growth. We revealed that these temperature‐mediated changes are determined by the composite effect of the macroscale property of polymer solution and the microscale dynamics of polymer chain as well as nanoparticles. Furthermore, the measured non‐Gaussian displacement probability distributions were found to exhibit non‐Gaussian fat tails, and the tailed distribution is enhanced as the temperature increases. The non‐Gaussianity was calculated and found to vary in the same trend with the tailed distribution, suggesting the occurrence of hopping events. This temperature‐mediated non‐Gaussian feature validates the recent theory of thermally induced activated hopping. Our results highlight the temperature‐mediated changes in diffusive transport of nanoparticles in polymer solutions and may provide the possible strategy to improve drug delivery in physiological media.