Temperature-responsive supramolecular hydrogels

Xian, Sijie; Webber, Matthew J.

doi:10.1039/d0tb01814g

Cited by 105 publications

(70 citation statements)

References 217 publications

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“…Another application field for thermo-responsive materials is biomedicine and drug delivery. [75][76][77][78][79] Fore xample,i nverse optical particles obtained from poly(N-isopropylacrylamide) (pNIPAM) hydrogels show thermo-responsive characteristics. [80] Depending on the temperature,the particles shrink or swell accompanied by ac olor change form red to blue,a s depicted in Figure 6A,making them an ideal system for drug delivery applications.T he particles provide macropores for active drug loading, which can be precisely released by adjusting the temperature.I ntriguingly,t he drug release was fine-tuned, hence allowing for the regulation of the drug delivery and the recovery of the initial particles (Figure 6B).…”

Section: Thermo-responsive Materialsmentioning

confidence: 99%

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Prevent or Cure—The Unprecedented Need for Self‐Reporting Materials

2021

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Hatice Mutlu, born in Bulgaria, studied Chemistry at Marmara University and Bogazici University.S ubsequently, she obtained her PhD from the Karlsruhe Institute of Technology (KIT) in the group of M. A. R. Meier.After post-doctoral stays in the groups of J.-F. Lutz (ICS-CNRS, Strasbourg) and C. Barner-Kowollik (KIT), she currently works as asenior researcher at KIT.Her research interest spans from the synthesis of complex macromolecular architecturesand functional polymers to the development of new polymer-forming reactions and novel conjugation chemistries with aparticularfocus on the design of novel sulfur-based and self-reporting materials. Christopher Barner-Kowollik, Australian Research Council (ARC) Laureate Fellow, graduated in chemistry from Gçttingen University,G ermany,and joined the University of New South Wales in early 2000 rising to lead the Centre for Advanced Macromolecular Design in 2006 as one of its directors. He returned to Germany to the KIT in 2008, where he establishedand led aDFG-funded Centre of Excellence in soft matter synthesis. He moved to QUT in 2017 and established QUT'sSoft Matter Materials Laboratory. His research achievements have been recognized by an array of national and international awards.

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Section: Thermo-responsive Materialsmentioning

confidence: 99%

“…Another application field for thermo‐responsive materials is biomedicine and drug delivery [75–79] . For example, inverse optical particles obtained from poly( N ‐isopropylacrylamide) (pNIPAM) hydrogels show thermo‐responsive characteristics [80] .…”

Section: Stimuli‐responsive Self‐reporting Polymeric Materialsmentioning

confidence: 99%

Prevent or Cure—The Unprecedented Need for Self‐Reporting Materials

2021

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“…Ein weiteres Anwendungsgebiet fürw ärmeempfindliche Materialien betrifft die Biomedizin und den Tr ansport von Medikamenten. [75][76][77][78][79] Zum Beispiel zeigen inverse optische Partikel aus Poly(N-isopropylacrylamid) (pNIPAM)-Hydrogelen temperaturabhängige Eigenschaften. [80] Je nach Temperatur schrumpfen oder schwellen die Partikel und ändern ihre Farbe von Rot nach Blau, wie in Abbildung 6A dargestellt, wodurch sie ideal fürden Tr ansport von Medikamenten geeignet sind.…”

Section: Thermoresponsive Materialienunclassified

“…Ein weiteres Anwendungsgebiet für wärmeempfindliche Materialien betrifft die Biomedizin und den Transport von Medikamenten [75–79] . Zum Beispiel zeigen inverse optische Partikel aus Poly( N ‐isopropylacrylamid) (pNIPAM)‐Hydrogelen temperaturabhängige Eigenschaften [80] .…”

Section: Stimuliresponsive Selbstberichtende Polymere Materialienunclassified

Vorbeugen oder Heilen – die beispiellose Notwendigkeit von selbstberichtenden Materialien

2021

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Hatice Mutlu, geboren in Bulgarien, studierte Chemie an der Marmara Universitätu nd der Bogazici Universität. Anschließend promovierte sie am KIT in der Gruppe von M. A. R. Meier.Nach Postdoc-Aufenthalten in den Gruppen von J.-F. Lutz (ICS-CNRS, Straßburg) und C. Barner-Kowollik (KIT) arbeitet sie derzeit als leitende Wissenschaftlerin am KIT.I hr Forschungsinteresse reicht von der Synthese komplexer makromolekularer Architekturen und funktioneller Polymere bis hin zur Entwicklung neuer polymerbildender Reaktionen und neuartiger Konjugationschemien mit besonderem Schwerpunkta uf dem Design neuartiger schwefelbasierter und selbstberichtender Materialien. Christopher Barner-Kowollik schloss sein Chemistudium an der UniversitätG çttingen ab. Anfang 2000 ging er an die Universität New South Wales und übernahmdort 2006 als einer der Direktoren die Leitung des Centre for Advanced Macromolecular Design. 2008 kehrte er nach Deutschland an das KIT zurück, wo er einen DFG-gefçrderten SFB zu Synthese und Struktur weicher Materie aufbaute und leitete. 2017 wechselte er zur QUT und baute das QUT-Laborf ür weiche Materialwissenschaften auf. Seine Forschungsleistungen wurden durch eine Reihe von nationalen und internationalen Preisen anerkannt.

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“…Among this rich class of cyclic oligosaccharides, α-/β-/γ- CDs are widely studied as hosts for a variety of organic molecular guests because of their suitable size, amphiphilic structures, and good availability. Compared to other synthetic host systems, e.g., crown ethers [ 7 , 8 , 9 ], calixarenes [ 10 , 11 , 12 ], cucurbiturils [ 9 , 13 , 14 ], and pillararenes [ 15 , 16 , 17 ], CDs are less toxic and/or exhibit good water solubility and biocompatibility [ 11 , 18 ]. Their facile covalent modification also renders them highly promising candidates as functional delivery systems [ 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Structural Insights into the Host–Guest Complexation between β-Cyclodextrin and Bio-Conjugatable Adamantane Derivatives

Wang

et al. 2021

Molecules

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Understanding the host–guest chemistry of α-/β-/γ- cyclodextrins (CDs) and a wide range of organic species are fundamentally attractive, and are finding broad contemporary applications toward developing efficient drug delivery systems. With the widely used β-CD as the host, we herein demonstrate that its inclusion behaviors toward an array of six simple and bio-conjugatable adamantane derivatives, namely, 1-adamantanol (adm-1-OH), 2-adamantanol (adm-2-OH), adamantan-1-amine (adm-1-NH2), 1-adamantanecarboxylic acid (adm-1-COOH), 1,3-adamantanedicarboxylic acid (adm-1,3-diCOOH), and 2-[3-(carboxymethyl)-1-adamantyl]acetic acid (adm-1,3-diCH2COOH), offer inclusion adducts with diverse adamantane-to-CD ratios and spatial guest locations. In all six cases, β-CD crystallizes as a pair supported by face-to-face hydrogen bonding between hydroxyl groups on C2 and C3 and their adjacent equivalents, giving rise to a truncated-cone-shaped cavity to accommodate one, two, or three adamantane derivatives. These inclusion complexes can be terminated as (adm-1-OH)2⊂CD2 (1, 2:2), (adm-2-OH)3⊂CD2 (2, 3:2), (adm-1-NH2)3⊂CD2 (3, 3:2), (adm-1-COOH)2⊂CD2 (4, 2:2), (adm-1,3-diCOOH)⊂CD2 (5, 1:2), and (adm-1,3-diCH2COOH)⊂CD2 (6, 1:2). This work may shed light on the design of nanomedicine with hierarchical structures, mediated by delicate cyclodextrin-based hosts and adamantane-appended drugs as the guests.

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Temperature-responsive supramolecular hydrogels

Abstract: A subclass of hydrogels which are prepared from supramolecular interactions can realized enhanced functionality, especially in the context of biomedical applications, upon the inclusion of temperature-responsive properties.

Cited by 105 publications

References 217 publications

Prevent or Cure—The Unprecedented Need for Self‐Reporting Materials

Prevent or Cure—The Unprecedented Need for Self‐Reporting Materials

Vorbeugen oder Heilen – die beispiellose Notwendigkeit von selbstberichtenden Materialien

Structural Insights into the Host–Guest Complexation between β-Cyclodextrin and Bio-Conjugatable Adamantane Derivatives

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