Temperature‐sensitive hydrogel microspheres formed by liquid–liquid phase transitions of aqueous solutions of poly(N,N‐dimethylacrylamide‐co‐allyl methacrylate)

Yin, Xin; Stöver, Harald D. H.

doi:10.1002/pola.20523

Cited by 16 publications

(10 citation statements)

References 27 publications

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“…The pendant allyl groups were used to crosslink the polymers by free radical polymerization. Microparticles were produced with diameters ranging from 14–72 µm [183]. In another study, a comb copolymer of PEG, styrene and maleic anhydride was incubated with poly(diallyldimethylammonium chloride) to form complex coacervates (carboxylic acids were present in the copolymer due to partial hydrolysis of the anhydride groups).…”

Section: Instructive Examples Of Liquid-liquid Two Phase Systemsmentioning

confidence: 99%

Liquid–liquid two-phase systems for the production of porous hydrogels and hydrogel microspheres for biomedical applications: A tutorial review

2011

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Macroporous hydrogels may have direct applications in regenerative medicine as scaffolds to support tissue formation. Hydrogel microspheres may be used as drug delivery vehicles or as building blocks to assemble modular scaffolds. A variety of techniques exist to produce macroporous hydrogels and hydrogel microspheres. A subset of these relies on liquid-liquid two phase systems. Within this subset, vastly different types of polymerization processes are found. In this review, the history, terminology and classification of liquid-liquid two phase polymerization and crosslinking are described. Instructive examples of hydrogel microsphere and macroporous scaffold formation by precipitation/dispersion, emulsion and suspension polymerizations are used to illustrate the nature of these processes. The role of the kinetics of phase separation in determining the morphology of scaffolds and microspheres is also delineated. Brief descriptions of miniemulsion, microemulsion polymerization and ionotropic gelation are also included.

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Section: Instructive Examples Of Liquid-liquid Two Phase Systemsmentioning

confidence: 99%

Liquid–liquid two-phase systems for the production of porous hydrogels and hydrogel microspheres for biomedical applications: A tutorial review

2011

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“…In addition, in the last few years, the synthesis of polymers having polymerizable groups has been an active field of research because it provides an approach to subsequent modification of the polymers for a required application. Thus, for example, random copolymers of N,N ‐dimethylacrylamide and AMA form novel thermosensitive hydrogel microspheres, and such materials may find applications in protein separation and protein delivery 15…”

Section: Introductionmentioning

confidence: 99%

Supratentorial extraventricular ependymal neoplasms

Shuangshoti

Rushing

Mena

et al. 2005

Cancer

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Objective Transient amnesia can be the principal manifestation of epilepsy. This diagnosis, however, is seldom suspected by clinicians and remains controversial. The amnestic attacks are often associated with persistent memory complaints. This study was designed to provide the first description of transient epileptic amnesia in a substantial series of patients. Methods Fifty patients were recruited over 18 months using the following diagnostic criteria: (1) recurrent, witnessed episodes of amnesia; (2) other cognitive functions intact during attacks; and (3) compelling evidence of epilepsy. We assessed clinical features and performed neuropsychological evaluation in cases and 24 matched control subjects. Results Transient epileptic amnesia develops in later life (mean onset, 62 years). Amnestic episodes are frequent (median, 12/year), brief (median duration, 30–60 minutes), and often occur on waking (37/50 cases). Epilepsy was the initial specialist diagnosis in only 12 of 50 cases. Attacks ceased on anticonvulsant medication in 44 of 47 treated patients. A total of 40 of 50 cases described persistent memory difficulties. Despite normal performance on standard memory tests, patients exhibited accelerated forgetting of verbal and visual material over 3 weeks by comparison with matched control subjects (p < 0.001). They also showed loss of autobiographical memories for events extending back over 40 years (p < 0.05). Interpretation We propose that transient epileptic amnesia is a distinctive epilepsy syndrome, typically misdiagnosed at presentation and associated with accelerated long‐term forgetting and autobiographical amnesia. The syndrome is of clinical and theoretic importance. Ann Neurol 2007

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“…Studies on DMA based copolymers have reported excellent characteristics. However, the mechanical strength of these synthesized hydrogels is weak [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antibacterial Application of Copolymers Based on N,N-Dimethyl Acrylamide and Acrylic Acid

Nakan

Bieerkehazhi

Tolkyn³

et al. 2021

Materials

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Hydrogel copolymers based on N,N-dimethyl acrylamide (DMA) and acrylic acid (AAc) were synthesized using a solution polymerization technique with different monomer ratios and ammonium persulfate as an initiator. This paper investigates the thermal stability, physical and chemical properties of the hydrogel copolymer. Testing includes Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and elemental analysis (CHNS). The copolymer composition was determined by elemental analysis, and the reactivity ratios of monomers were calculated through linearization methods such as Fineman–Ross (FR), inverted Fineman–Ross (IFR), Kelen–Tudos (KT) and Mayo–Lewis (ML). Good agreement was observed between the results of all four methods. The ratio of r1 and r2 were 0.38 (r1) and 1.45 (r2) (FR), 0.38 (r1) and 1.46 (r2) (IFR), 0.38 (r1) and 1.43 (r2) (KT), and 0.38 (r1) and 1.45 (r2) (ML). Hydrogel copolymers exhibited good thermal stability, and SEM showed three-dimensional porous structures. Antibiotic-free and antibiotic-loaded hydrogels demonstrated antimicrobial properties against both Gram-positive and Gram-negative bacteria. As the ratio of DMA in hydrogel copolymer increased, the activity of copolymer against bacteria enhanced. The results indicated that these hydrogels have the potential to be used as antibacterial materials.

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Temperature‐sensitive hydrogel microspheres formed by liquid–liquid phase transitions of aqueous solutions of poly(N,N‐dimethylacrylamide‐co‐allyl methacrylate)

Cited by 16 publications

References 27 publications

Liquid–liquid two-phase systems for the production of porous hydrogels and hydrogel microspheres for biomedical applications: A tutorial review

Liquid–liquid two-phase systems for the production of porous hydrogels and hydrogel microspheres for biomedical applications: A tutorial review

Supratentorial extraventricular ependymal neoplasms

Synthesis, Characterization and Antibacterial Application of Copolymers Based on N,N-Dimethyl Acrylamide and Acrylic Acid

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