Temperature-sensitive polymeric nanogels encapsulating with β-cyclodextrin and ICG complex for high-resolution deep-tissue ultrasound-switchable fluorescence imaging

Liu, Ruilin; Yao, Tingfeng; Liu, Yang; Yu, Shaoming; Ren, Lele; Hong, Yi; Nguyen, Kytai T.; Yuan, Baohong

doi:10.1007/s12274-020-2752-6

Cited by 16 publications

(25 citation statements)

References 41 publications

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“…The ultrasound-modulated tactics can realize good acoustic resolution in deep scattering media during the fluorescence imaging. However, manipulating the on/off signals of the NIR fluorescence imaging probe in living tissues via an ultrasonic modulator remains a significant challenge [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Ultrasound-controlled fluorescence (UCF) imaging can effectively address the issues mentioned above; thus, this technique has garnered considerable attention in recent years [ [16] , [17] , [18] , [19] , [20] , [21] ]. The unique UCF imaging probe with temperature-responsive property can be quickly unlocked via ultrasound-controlled approach only in the ultrasound confined space [ 17 ]. In addition, the UCF imaging system is different from the traditional fluorescence imaging system because the collected UCF signal is only derived from the signal changes of the UCF probe; in addition, the signal strength can be facilely adjusted by an ultrasonic modulator.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the UCF imaging system is different from the traditional fluorescence imaging system because the collected UCF signal is only derived from the signal changes of the UCF probe; in addition, the signal strength can be facilely adjusted by an ultrasonic modulator. Overall, the excellent UCF contrast agent and the sensitive UCF imaging system facilitate both ex vivo and/or in vivo high-resolution imaging [ 17 ]. Therefore, to develop a novel UCF probe and simultaneously build a sensitive UCF imaging system is a great challenge.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging

Liu

Cai

2022

Journal of Pharmaceutical Analysis

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging

Liu

Cai

2022

Journal of Pharmaceutical Analysis

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“…Ultrasound-sensitive fluorescent agents can be synthesized in either microbubble [16,18] or nanoparticle forms [10,13,19,20]. Microbubbles expand and contract in response to incident acoustic waves.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Phase-Changing Perfluorocarbon Nanodroplets as Activatable Near-Infrared Probes

Spatarelu

Namen

Jandhyala

et al. 2022

IJMS

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The sensitivity of fluorescence imaging is limited by the high optical scattering of tissue. One approach to improve sensitivity to small signals is to use a contrast agent with a signal that can be externally modulated. In this work, we present a new phase-changing perfluorocarbon nanodroplet contrast agent loaded with DiR dye. The nanodroplets undergo a liquid-to-gas phase transition when exposed to an externally applied laser pulse. This results in the unquenching of the encapsulated dye, thus increasing the fluorescent signal, a phenomenon that can be characterized by an ON/OFF ratio between the fluorescence of activated and nonactivated nanodroplets, respectively. We investigate and optimize the quenching/unquenching of DiR upon nanodroplets’ vaporization in suspension, tissue-mimicking phantoms and a subcutaneous injection mouse model. We also demonstrate that the vaporized nanodroplets produce ultrasound contrast, enabling multimodal imaging. This work shows that these nanodroplets could be applied to imaging applications where high sensitivity is required.

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Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents

Kubeil,

Suzuki,

Casulli

et al. 2023

Adv Healthcare Materials

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Nanogels open up access to a wide range of applications and offer among others hopeful approaches for use in the field of biomedicine. This review provides a brief overview of current developments of nanogels in general, particularly in the fields of drug delivery, therapeutic applications, tissue engineering and sensor systems. Specifically, cyclodextrin (CD)‐based nanogels are important because they have exceptional complexation properties and are highly biocompatible. Nanogels as a whole and CD‐based nanogels in particular can be customized in a wide range of sizes and equipped with a desired surface charge as well as containing additional molecules inside and outside, such as dyes, solubility‐mediating groups or even biological vector molecules for pharmaceutical targeting. Currently, biological investigations are mainly carried out in vitro, but more and more in vivo applications are gaining importance. Modern molecular imaging methods are increasingly being used for the latter. Due to an extremely high sensitivity and the possibility of obtaining quantitative data on pharmacokinetic and pharmacodynamic properties, nuclear methods such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) using radiolabeled compounds are particularly suitable here. The use of radiolabeled nanogels for imaging, but also for therapy, is being discussed.This article is protected by copyright. All rights reserved

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Temperature-sensitive polymeric nanogels encapsulating with β-cyclodextrin and ICG complex for high-resolution deep-tissue ultrasound-switchable fluorescence imaging

Cited by 16 publications

References 41 publications

Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging

Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging

Fluorescent Phase-Changing Perfluorocarbon Nanodroplets as Activatable Near-Infrared Probes

Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents

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