Temperature triggered high-performance carbon dots with robust solvatochromic effect and self-quenching-resistant deep red solid state fluorescence for specific lipid droplet imaging

Gao, Dongwen; Liu, Amin; Zhang, Yusheng; Zhu, Yuda; Wei, Dan; Sun, Jing; Luo, Hongrong; Fan, Hongsong

doi:10.1016/j.cej.2021.128984

Cited by 70 publications

(39 citation statements)

References 55 publications

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“…Several CDs have been reported for imaging lipid droplets. [112][113][114][115][116][117][118][119] Gao et al prepared CDs (R-CDs210) with a high PLQY (73% for yellow fluorescence) from thiourea and o-phenylenediamine through a solvothermal method (Figure 3C). [112] In particular, R-CDs210 exhibited deep-red solid-state fluorescence, as the polymer chains on their surface impeded the direct contact between their subfluorophores and carbonized core.…”

Section: Lipid Dropletmentioning

confidence: 99%

“…[112][113][114][115][116][117][118][119] Gao et al prepared CDs (R-CDs210) with a high PLQY (73% for yellow fluorescence) from thiourea and o-phenylenediamine through a solvothermal method (Figure 3C). [112] In particular, R-CDs210 exhibited deep-red solid-state fluorescence, as the polymer chains on their surface impeded the direct contact between their subfluorophores and carbonized core. Moreover, R-CDs210 possessed an evident solvatochromic effect with an emission shift (up to %132 nm) from green to far-red region when the solvent polarity was elevated, which was accompanied with the decrease in the PLQY from 73% to 1%.…”

Section: Lipid Dropletmentioning

confidence: 99%

“…C) Scheme showing the fabrication of R-CDs210, and confocal microscopic images of Hep G2 cells costained with R-CDs210 and BODIPY 493/503. Reproduced with permission [112]. Copyright 2021, Elsevier.…”

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confidence: 99%

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Carbon Dots for Intracellular Sensing

Lin

Jia

2022

Small Structures

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Carbon dots (CDs), a type of small, carbon element‐based nanomaterials, have found numerous applications in many fields due to their outstanding properties like fascinating photoluminescence characteristic, great biocompatibility, easy and economical synthesis, and facile functionalization. Over the last decade, huge progress and achievements have been made in terms of the applications of CDs in cellular detection. However, a comprehensive review focusing on this topic is still lacking. Herein, the recent progress in CDs‐mediated intracellular detection, including the fluorescence imaging of cellular structures (e.g., nucleus/nucleolus, mitochondrion, lysosome, endoplasmic reticulum, Golgi apparatus, and lipid droplet), the fluorescence detection of a large variety of cellular substances (including endogenous biomacromolecules and their monomers, vitamins, important metabolites, adenosine triphosphate, reactive oxygen species, biothiols, ions, and exogenous compounds), and the monitoring of cellular parameters (pH, temperature, and mitochondrial membrane potential), is thoroughly reviewed. The synthesis, functionalization, and performance of the CDs that serve as fluorescent nanoprobes in living cells are presented. Their underlying working mechanisms are also discussed if available. Finally, the challenges and future research directions of the related research field are listed. This review may foster the future development of more CDs with better cellular sensing performance.

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Section: Lipid Dropletmentioning

confidence: 99%

Section: Lipid Dropletmentioning

confidence: 99%

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Carbon Dots for Intracellular Sensing

Lin

Jia

2022

Small Structures

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“…Carbon dots (CDs), a novel type of fluorescent nanomaterial, are being increasingly used in sensing, bioimaging, catalysis, and light-emitting diodes, given their attractive features such as tunable photoluminescence, biocompatibility, readily available raw materials, and simple preparation. − Although CDs have been successfully applied to target various organelles, such as the lysosomes, mitochondria, endoplasmic reticulum, and nucleolus, − research on LD-targeting CDs is limited. To the best of our knowledge, only two LD-targeting CD reports have been published. , Fan and co-workers reported LD-targeting CDs based on the control of the temperature during synthesis, while Yu and co-workers described a room-temperature oxidative polymerization method. A primary reason for this deficiency is the lack of effective LD-targeting groups that can be readily incorporated in the design of probes, unlike other organelles such as the lysosome (targetable by the morpholine group), mitochondria (high affinity for the triphenylphosphonium group), and the endoplasmic reticulum (sulfonamide group). , In addition, the synthesis of CDs is akin to a “black box” type of reaction, making it challenging to design CDs with the desired optical and binding properties.…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, only two LD-targeting CD reports have been published. 28,29 Fan and co-workers reported LD-targeting CDs based on the control of the temperature during synthesis, while Yu and co-workers described a room-temperature oxidative polymerization method. A primary reason for this deficiency is the lack of effective LD-targeting groups that can be readily incorporated in the design of probes, unlike other organelles such as the lysosome (targetable by the morpholine group), mitochondria (high affinity for the triphenylphosphonium group), and the endoplasmic reticulum (sulfonamide group).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Structure–Activity Relationship Enables the Rational Design of Lipid Droplet-Targeting Carbon Dots for Visualizing Bisphenol A-Induced Nonalcoholic Fatty Liver Disease-like Changes

Wang

Guo

Geng

et al. 2021

ACS Appl. Mater. Interfaces

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Lipid droplets (LDs) play indispensable roles in numerous physiological processes; hence, the visualization of the dynamic behavior of LDs in living cells is of great importance in physiological and pathological research. In this article, the quantitative structure–activity relationship (QSAR) theory was employed as an effective design strategy for the development of organelle-targeting carbon dots (CDs). The lipid–water partition coefficient (Log P) of the QSAR was adopted as a key parameter to predict the cellular uptake and subcellular localization of CDs in live cells. By carefully adjusting the molecular structure and lipophilicity of the precursors, p-phenylenediamine-derivatized nucleolus-targeting hydrophilic CDs were converted to lipophilic CDs [4-piperidinoaniline (PA) CDs] with inherent LD-targeting performance. The PA CDs were able to indicate the dynamic behavior of LDs and visualize the changes of bisphenol A-induced nonalcoholic fatty liver disease-like changes in a cellular model. The QSAR strategy of CDs demonstrated here is expected to be increasingly exploited as a powerful design tool for developing various organelle-targeting CDs.

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Innovations in the Solid‐State Fluorescence of Carbon Dots: Strategies, Optical Manipulations, and Applications

Wang

Song

et al. 2023

Adv Funct Materials

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Carbon dots (CDs)—carbon nanoparticles smaller than 10 nm—have attracted widespread attention owing to their excellent optical properties. However, high‐performing CDs often suffer from severe aggregation‐induced quenching in the solid state, which limits their commercial applicability. Therefore, CD materials with efficient solid‐state luminescence are sought. As research on the structure and photoluminescence mechanisms of CDs has intensified in recent years, strategies to construct fluorescent solid‐state CD materials and tune their emissions have broadened. This article reviews recent advances in the strategies and mechanisms for attaining solid‐state fluorescence in CDs, describes specific ways to tune the optical properties of this fluorescence, introduces the latest applications of the resulting CDs to optoelectronics, biology, and sensing, and finally considers the prospects for future application and current challenges facing the development of solid‐state fluorescence in CDs.

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Temperature triggered high-performance carbon dots with robust solvatochromic effect and self-quenching-resistant deep red solid state fluorescence for specific lipid droplet imaging

Cited by 70 publications

References 55 publications

Carbon Dots for Intracellular Sensing

Carbon Dots for Intracellular Sensing

Quantitative Structure–Activity Relationship Enables the Rational Design of Lipid Droplet-Targeting Carbon Dots for Visualizing Bisphenol A-Induced Nonalcoholic Fatty Liver Disease-like Changes

Innovations in the Solid‐State Fluorescence of Carbon Dots: Strategies, Optical Manipulations, and Applications

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