Template-Monomer Interaction in Molecular Imprinting: Is the Strongest the Best?

Fu, Xuewen; Yang, Qiang; Zhou, Qiang; Lin, Qiang; Wang, Chun

doi:10.4236/ojopm.2015.52007

Cited by 29 publications

(13 citation statements)

References 25 publications

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“…There have been extensive studies for the choice of the starting materials and synthesis routes leading to the preparation of MIPs [6,18,19]. The functional monomers should strongly interact with the template molecules, but other parameters also matter [20,21]. Such interactions depend also on the liquid medium used during the copolymerization.…”

Section: Discussionmentioning

confidence: 99%

Design of Molecularly Imprinted Polymeric Materials: The Crucial Choice of Functional Monomers

Anene¹,

Kalfat²,

Chevalier

et al. 2020

Chemistry Africa

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The choice of the functional monomer is addressed in the present study. It is not only dictated by its ability to interact with the template molecule. Its reactivity towards the cross-linker in the radical polymerization reaction is also to be considered in order to yield a suitable distribution of the monomer bearing binding groups within the material and also to adjust the cross-linking degree which provides rigidity to MIP network. MIPs prepared using two functional monomers of very different reactivity in radical polymerization allowed to investigate the criteria for the optimum choice of the functional monomer. MIPs were made of cross-linked poly(methacrylic acid) or poly(maleic acid) bound as thin films to a silica solid support. Ethylene glycol dimethacrylate was the cross-linker. Calculations of the composition drift of the copolymer material from monomers reactivity ratios give new insights into the control of MIP properties by the choice of the functional monomer. As a consequence of the lower reactivity of maleic acid than methacrylic acid for copolymerization with methacrylic esters, the incorporation of maleic acid is low, the cross-linking density is very high, the polymer coating is very thin, and the specific area is high. The final structure of the MIP network with a predominance of isolated functional units closely surrounded by cross-links yields a rigid material capable of preserving the memory of the model molecule of patulin in molecular imprints. Low reactivity of the functional monomer has beneficial effects regarding the binding selectivity for the target molecule compared to materials prepared from the more reactive methacrylic acid which lead to the formation of flexible polymer formed of short poly(methacrylic acid) sequences.

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Section: Discussionmentioning

confidence: 99%

Design of Molecularly Imprinted Polymeric Materials: The Crucial Choice of Functional Monomers

Anene¹,

Kalfat²,

Chevalier

et al. 2020

Chemistry Africa

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“…The interaction between the template and functional monomer should be as strong as possible during the polymerization . Experimental method and computational modeling are used in order to evaluate the interaction between template and functional monomer. The imprinting procedure is generally based on the linkage of suitable monomers containing functional groups to template molecules by some kind of interactions.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a stoichiometric molecularly imprinted polymer for auramine O and application in solid‐phase extraction

Pataer

Muhammad

Turahun

et al. 2019

J of Separation Science

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We describe a stoichiometric approach to the synthesis of molecularly imprinted polymers specific for auramine O. Using the stoichiometric interaction in molecular imprinting, no excess of binding sites is necessary and binding sites are only located inside the imprinted cavities. The free base of the template was obtained to facilitate the interaction with the monomers. Itaconic acid was selected as the functional monomer, and stoichiometric ratio of the interaction with the free base was investigated. The molecularly imprinted polymer preparation conditions such as cross-linker, molar ratio, porogen were optimized as divinylbenzene, 1:2:20 and chloroform/N,Ndimethylformamide, respectively. Under the optimum conditions, a good imprinting effect and very high selectivity were achieved. A solid-phase extraction method was developed using the molecularly imprinted polymers as a sorbent and extraction procedure was optimized. The solid-phase extraction method showed a high extraction recovery for auramine O in its hydrochloride form and free form compared to its analogues. The results strongly indicated that stoichiometric imprinting is an efficient method for development of high selectivity molecularly imprinted polymers for auramine O. K E Y W O R D Sauramine O hydrochloride, molecularly imprinted polymers, rational design, solid-phase extraction, stoichiometric interactions 1634

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“…Functional monomers are an essential factor for binding interactions in molecular imprinting technology [ 51 ]. The functional monomer will influence the binding site affinity of a MIP [ 52 ]. In the MIP pre-polymerization, the functional monomers are going to interact with the template molecules [ 11 ].…”

Section: Choosing Right Component For Mipmentioning

confidence: 99%

“…The strength and affinity of the template-monomer will affect the selectivity and affinity of the polymer. Therefore, it is crucial to determine the suitable functional monomer which will interact strongly with the template to form a stable complex [ 52 ].…”

Section: Analysis Of Template-monomer Functional Interactionsmentioning

confidence: 99%

Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials

et al. 2021

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Molecular imprinting is a technique for creating artificial recognition sites on polymer matrices that complement the template in terms of size, shape, and spatial arrangement of functional groups. The main advantage of Molecularly Imprinted Polymers (MIP) as the polymer for use with a molecular imprinting technique is that they have high selectivity and affinity for the target molecules used in the molding process. The components of a Molecularly Imprinted Polymer are template, functional monomer, cross-linker, solvent, and initiator. Many things determine the success of a Molecularly Imprinted Polymer, but the Molecularly Imprinted Polymer component and the interaction between template-monomers are the most critical factors. This review will discuss how to find the interaction between template and monomer in Molecularly Imprinted Polymer before polymerization and after polymerization and choose the suitable component for MIP development. Computer simulation, UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Proton-Nuclear Magnetic Resonance (1H-NMR) are generally used to determine the type and strength of intermolecular interaction on pre-polymerization stage. In turn, Suspended State Saturation Transfer Difference High Resolution/Magic Angle Spinning (STD HR/MAS) NMR, Raman Spectroscopy, and Surface-Enhanced Raman Scattering (SERS) and Fluorescence Spectroscopy are used to detect chemical interaction after polymerization. Hydrogen bonding is the type of interaction that is becoming a focus to find on all methods as this interaction strongly contributes to the affinity of molecularly imprinted polymers (MIPs).

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Template-Monomer Interaction in Molecular Imprinting: Is the Strongest the Best?

Cited by 29 publications

References 25 publications

Design of Molecularly Imprinted Polymeric Materials: The Crucial Choice of Functional Monomers

Design of Molecularly Imprinted Polymeric Materials: The Crucial Choice of Functional Monomers

Preparation of a stoichiometric molecularly imprinted polymer for auramine O and application in solid‐phase extraction

Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials

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