Template synthesis, spectroscopic studies and biological activities of macrocyclic complexes derived from thiocarbohydrazide and glyoxal

Abstract

A novel series of complexes of the type [M(TML)X 2 ]; where TML is Tetradentate Macrocyclic Ligand; M ¼ Co(II), Ni(II), Cu(II), Zn(II)or Cd(II); X ¼ Cl 2 , CH 3 COO 2 or NO 2 3 have been synthesized by template condensation of glyoxal and thiocarbohydrazide in the presence of divalent metal salts in methanolic medium. The complexes have been characterized by elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. Electronic spectra along with magnetic moments suggest a six coordinate octahedral geometry for these complexes. The low molar conductance values indicates them to be non-electrolytes. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibitory potential.

Antibacterial activity and spectral studies of trivalent chromium, manganese, iron macrocyclic complexes derived from oxalyldihydrazide and glyoxal

“…Macrocyclic complexes have attracted attention because of their pharmacological properties i.e. toxicity against bacterial and fungal growth [8,9]. Some macrocyclic complexes have been reported to have anti-inflammatory approach [10].…”

Antibacterial and antifungal studies of macrocyclic complexes of trivalent transition metal ions with their spectroscopic approach

“…Macrocyclic metal complexes of lanthanides, e.g. Gd 3+ , are used as MRI contrast agents 20 . Macrocyclic metal chelating agents (DOTA) are useful for detecting tumor lesions 21 .…”

Synthesis, Spectral and Antimicrobial Studies of Some d10 Metal-Ions Ditellura Tetraazamacrocyclic Complexes

“…The chemistry of macrocyclic ligands and their metal complexes has become a growing class of research and received the attention of both bioinorganic and inorganic chemists in recent years 1,2 . Due to the presence of various donor atoms in macrocycle and their pliancy and ability to coordinate with metal ions, transition metal complexes are of great importance in synthesis 3 .…”