Temporal acuity is preserved in the auditory midbrain of aged mice

Land, Rüdiger; Kral, Andrej

doi:10.1016/j.neurobiolaging.2021.10.009

Cited by 5 publications

(5 citation statements)

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“…Such stability of temporal resolution in aging has been described in the IC and cortex of normal hearing mice (Osterhagen and Hildebrandt, 2018; Land and Kral, 2022), and age-related changes in central temporal acuity in the midbrain can often be explained by inherited peripheral effects (Land and Kral, 2022). Thus, the issue of confounding peripheral effects remains central, as existing studies on gap detection (Barsz et al, 2002; Walton et al, 2008; Ross et al, 2010; Shen, 2014) indicate an upper limit of pure age-related changes in the auditory midbrain if no other pathological states are present.…”

Section: Discussionmentioning

confidence: 99%

“…Our results support the differentiation of auditory pathway stages with respect to central presbycusis. Although brainstem, auditory midbrain, and thalamus population processing often is stable in old animals with normal hearing (Lee et al, 2002;Mendelson and Lui, 2004;Osterhagen and Hildebrandt, 2018;Land and Kral, 2022), small effects may cumulate towards higher levels of the auditory system (Mendelson and Lui, 2004;Occelli et al, 2019;Quraishe et al, 2020), affecting the precision of cortical processing, which is critical for temporal and complex sound and processing (Nourski and Brugge, 2011;Nourski et al, 2021aNourski et al, , 2021b. Elongation of cortical potentials is present in aged mice (Mei et al, 2021), and middle latency and cortical evoked potentials in aged humans (Goodin et al, 1978;Dum, 1983;Allison et al, 1984;Martini et al, 1991;Gourévitch and Edeline, 2011;Price et al, 2017;Occelli et al, 2019).…”

Section: Relation To Other Age-related Factors Influencing Hearing Pr...mentioning

confidence: 99%

“…In comparison to peripheral and cognitive effects (Eckert et al, 2021), age-related central processing deficits - sometimes referred to as ‘central presbycusis’-are less clear. Mixed evidence has led some authors to question the existence of a ‘pure’ age-related central auditory decline in isolation without being confounded by ‘indirect’ effects of cochlear damage or top-down cognitive factors (Humes et al, 2012; Atcherson et al, 2015; Land and Kral, 2022). This is reflected by the fact, that variability in findings on simple measures support both sides, the preservation of central temporal acuity in aging, as well as its decline, e.g.…”

Section: Introductionmentioning

confidence: 99%

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Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays

Land

Kral

2022

Preprint

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The extent to which aging of the central auditory pathway impairs auditory perception in the elderly independent of peripheral cochlear decline is debated. To cause auditory deficits in normal hearing elderly, central aging needs to degrade neural sound representations at some point along the auditory pathway. However, inaccessible to psychophysical methods, the level of the auditory pathway at which aging starts to effectively degrade neural sound representations remains poorly differentiated. Here we tested how potential age-related changes in the auditory brainstem affect the stability of spatiotemporal multiunit complex speech-like sound representations in the auditory midbrain of old normal hearing CBA/J mice. Although brainstem conduction speed slowed down in old mice, the change was limited to the sub-millisecond range and only minimally affected temporal processing in the midbrain (i.e. gaps-in-noise sensitivity). Importantly, besides the small delay, multiunit complex temporal sound representations in the auditory midbrain did not differ between young and old mice. This shows that although small age-related neural effects in simple sound parameters in the lower brainstem may be present in aging they do not effectively deteriorate complex neural population representations at the level of the auditory midbrain when peripheral hearing remains normal. This result challenges the widespread belief of pure central auditory decline as an automatic consequence of aging. However, the stability of midbrain processing in aging emphasizes the role of undetected 'hidden' peripheral damage and accumulating effects in higher cortical auditory-cognitive processing explaining perception deficits in 'normal hearing' elderly.

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Section: Discussionmentioning

confidence: 99%

Section: Relation To Other Age-related Factors Influencing Hearing Pr...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays

Land

Kral

2022

Preprint

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“…However, there are few studies on the binaural advantages in sound temporal information processing. Gap detection threshold (GDT), which measures the ability to detect the shortest silent interval in a sound, is widely used to assess the auditory temporal resolution and evaluate the ability of auditory system in sound temporal processing ( Werner et al, 1992 ; Pysanenko et al, 2021 ; Land and Kral, 2022 ). Shorter GDTs indicate higher temporal acuity in decoding of the sound stream, such as speech stream of human and communication sounds of animals.…”

Section: Introductionmentioning

confidence: 99%

“…The neuronal correlates of gap detection in the central auditory system have been determined in the inferior colliculus ( Walton et al, 1997 ; Weible et al, 2020 ; Land and Kral, 2022 ), auditory thalamus ( Anderson and Linden, 2016 ), and auditory cortex ( Eggermont, 1999 ; Recanzone et al, 2011 ; Jiang et al, 2015 ; Zhao et al, 2015 ; Keller et al, 2018 ; Awwad et al, 2020 ) across different animal species. These studies determined the GDTs of auditory neurons under either binaural conditions or monaural conditions without a direct comparison of GDTs under both conditions.…”

Section: Introductionmentioning

confidence: 99%

Binaural advantages in sound temporal information processing by neurons in the rat inferior colliculus

Li,

Zhang

2023

Front. Neurosci.

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Previous studies on the advantages of binaural hearing have long been focused on sound localization and spatial stream segregation. The binaural advantages have also been observed in speech perception in reverberation. Both human speech and animal vocalizations contain temporal features that are critical for speech perception and animal communication. However, whether there are binaural advantages for sound temporal information processing in the central auditory system has not been elucidated. Gap detection threshold (GDT), the ability to detect the shortest silent interval in a sound, has been widely used to measure the auditory temporal resolution. In the present study, we determined GDTs of rat inferior collicular neurons under both monaural and binaural hearing conditions. We found that the majority of the inferior collicular neurons in adult rats exhibited binaural advantages in gap detection, i.e., better neural gap detection ability in binaural hearing conditions compared to monaural hearing condition. However, this binaural advantage in sound temporal information processing was not significant in the inferior collicular neurons of P14-21 and P22-30 rats. Additionally, we also observed age-related changes in neural temporal acuity in the rat inferior colliculus. These results demonstrate a new advantage of binaural hearing (i.e., binaural advantage in temporal processing) in the central auditory system in addition to sound localization and spatial stream segregation.

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Research progress of the inferior colliculus: from Neuron, neural circuit to auditory disease

Liu,

Wang,

Jiang

et al. 2024

Brain Research

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Temporal acuity is preserved in the auditory midbrain of aged mice

Cited by 5 publications

References 83 publications

Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays

Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays

Binaural advantages in sound temporal information processing by neurons in the rat inferior colliculus

Research progress of the inferior colliculus: from Neuron, neural circuit to auditory disease

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