Temporal and spatial characterization of myopia in China

Shi, Xiujing; Gao, Zhaorong; Leng, Lin; Guo, Zhen

doi:10.3389/fpubh.2022.896926

Cited by 13 publications

(7 citation statements)

References 44 publications

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“…Myopia is a major public health concern precipitated by its increasing prevalence worldwide 1–7 and the associated risk of potentially blinding conditions 8–12 . Projections indicate that by the year 2050, over half of the world's population will have myopia, with 10% of those having high myopia 13 .…”

Section: Introductionmentioning

confidence: 99%

Baseline metrics that may predict future myopia in young children

Vera-Díaz

Jnawali

Panorgias

et al. 2023

Ophthalmic Physiologic Optic

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Myopia is a major public health concern precipitated by its increasing prevalence worldwide 1-7 and the associated risk of potentially blinding conditions. [8][9][10][11][12] Projections indicate that by the year 2050, over half of the world's population will have myopia, with 10% of those having high myopia. 13 Individuals with myopia, even low to moderate myopia, are at higher risk for a number of ocular pathologies, including myopic maculopathy, glaucoma, retinal detachment and certain types of cataract. 14,15 Furthermore, the increasingly earlier onset of myopia in children with consequent higher progression rates is generating an epidemic of potentially blinding, high myopia. For all these reasons, there is an urgent need to prevent myopia development and its progression.

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Section: Introductionmentioning

confidence: 99%

Baseline metrics that may predict future myopia in young children

Vera-Díaz

Jnawali

Panorgias

et al. 2023

Ophthalmic Physiologic Optic

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show abstract

“…The situation of myopia among adolescents is particularly serious, especially in East Asian countries. Adolescents (young people aged 10–19) ( Das et al, 2017 ) are crucial to the future development and progress of a country, and adolescent eye health is related to the national health ( Shi et al, 2022 ), therefore, the high incidence of myopia will bring a burden to society and families. Thus, to slow down or even prevent the high incidence rate of myopia, it is necessary to clarify the mechanism of its occurrence and development, and this is the main direction of myopia research at present.…”

Section: Introductionmentioning

confidence: 99%

Effects of exogenous retinoic acid on ocular parameters in Guinea pigs with form deprivation myopia

Feng

Yang

et al. 2023

Front. Cell Dev. Biol.

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Aim: Myopia is a common chronic eye disease, this study is to investigate the effects of exogenous retinoic acid (RA) on intraocular parameters, especially choroidal thickness (CT) and retinal thickness (RT), in guinea pigs with form deprivation myopia (FDM).Methods: A total of 80 male guinea pigs were divided randomly into 4 groups: Control, FDM, FDM + RA, and FDM + Citral groups. The FDM + RA group was given 24 mg/kg RA dissolved in 0.4 mL peanut oil; the FDM + Citral group was given citral 445 mg/kg dissolved in 0.4 mL peanut oil; The other two groups were given 0.4 mL peanut oil. After 4 weeks, the refractive error (RE), axial length (AL), and intraocular pressure (IOP) of all guinea pigs were measured, and the parameters of RT and CT were obtained using enhanced depth imaging optical coherence tomography (EDI-OCT).Results: After 4 weeks, both the RE and AL in the FDM and FDM + RA groups were increased, and the RT and CT in both groups were smaller than those in the Control group (p < 0.05). Only the IOP of the right eye in the FDM + RA group increased significantly (p < 0.05). The RT of the right eye of the 4 groups was compared: Control group > FDM + Citral group > FDM group > FDM + RA group. Compared with the RT of the left eye and the right eye among the 4 groups, the RT of the right eye in the FDM and FDM + RA groups was significantly less than that in the left eye (p < 0.05). Moreover, the CT of the right eye in the Control group was greater than that in the other three groups (p < 0.0001). There was no significant difference in the CT among the FDM, FDM + RA, and FDM + Citral groups (p > 0.05). In contrast to the RT results, the CT results of the left and right eyes in the FDM + Citral group showed statistically significant differences (p < 0.05).Conclusion: RA participates in the progression of FDM as a regulatory factor. Exogenous RA can increase the RE, AL, and IOP of FDM guinea pigs, and might aggravate the retinal thinning of FDM guinea pigs. Citral can inhibit these changes, but RA might not affect the thickness of the choroid.

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“…2 East Asian countries, especially China, have the highest prevalence of myopia, with studies indicating that more than 50% of high school students and young adults are affected by the condition. 3 Furthermore, the increasing prevalence of myopia among younger children and higher rates of progression during school years have led to an escalating burden. 4 High myopia is defined as a high degree of myopic refractive error ≤−6.00D and/or axial length (AL) ≥26.0 mm, 5 while pathological myopia is characterised by myopic maculopathy equal to or more severe than diffuse choroidal atrophy (META-analysis of Pathologic Myopia, META-PM) or the presence of posterior staphyloma.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Initiation of China Alliance of Research in High Myopia (CHARM): protocol for an AI-based multimodal high myopia research biobank

He,

Liu,

Song

et al. 2023

BMJ Open

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IntroductionHigh myopia is a pressing public health concern due to its increasing prevalence, younger trend and the high risk of blindness, particularly in East Asian countries, including China. The China Alliance of Research in High Myopia (CHARM) is a newly established consortium that includes more than 100 hospitals and institutions participating across the nation, aiming to promote collaboration and data sharing in the field of high myopia screening, classification, diagnosis and therapeutic development.Methods and analysisThe CHARM project is an ongoing study, and its initiation is distinguished by its unprecedented scale, encompassing plans to involve over 100 000 Chinese patients. This initiative stands out not only for its extensive scope but also for its innovative application of artificial intelligence (AI) to assist in diagnosis and treatment decisions. The CHARM project has been carried out using a ‘three-step’ strategy. The first step involves the collection of basic information, refraction, axial length and fundus photographs from participants with high myopia. In the second step, we will collect multimodal imaging data to expand the scope of clinical information, for example, optical coherence tomography and ultra-widefield fundus images. In the final step, genetic testing will be conducted by incorporating patient family histories and blood samples. The majority of data collected by CHARM is in the form of images that will be used to detect and predict the progression of high myopia through the identification and quantification of biomarkers such as fundus tessellation, optic nerve head and vascular parameters.Ethics and disseminationThe study has received approval from the Ethics Committee of Beijing Tongren Hospital (TREC2022-KY045). The establishment of CHARM represents an opportunity to create a collaborative platform for myopia experts and facilitate the dissemination of research findings to the global community through peer-reviewed publications and conference presentations. These insights can inform clinical decision-making and contribute to the development of new treatment modalities that may benefit patients worldwide.Trial registration numberChiCTR2300071219.

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Temporal and spatial characterization of myopia in China

Cited by 13 publications

References 44 publications

Baseline metrics that may predict future myopia in young children

Baseline metrics that may predict future myopia in young children

Effects of exogenous retinoic acid on ocular parameters in Guinea pigs with form deprivation myopia

Initiation of China Alliance of Research in High Myopia (CHARM): protocol for an AI-based multimodal high myopia research biobank

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