Temporal and spatial expression patterns for the tumor suppressor Maspin and its binding partner interferon regulatory factor 6 during breast development

Bailey, Caleb M.; Margaryan, Naira V.; Abbott, Daniel E.; Schutte, Brian C.; Yang, Baoli; Khalkhali‐Ellis, Zhila; Hendrix, Mary J.C.

doi:10.1111/j.1440-169x.2009.01110.x

Cited by 22 publications

(23 citation statements)

References 29 publications

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“…IRF6 has recently been shown to promote differentiation of zebrafish periderm by directly regulating the expression of Grainyhead-like 3 (GRHL3) (37). Despite these observations, subcellular localization studies indicate that IRF6 localizes to the cytoplasm both in vivo and in vitro (9,21,38,39) suggesting that, as with other IRF family members, IRF6 exists in an autoinhibited state until activated by phosphorylation (40). Although previous studies have indicated that IRF6 is subject to phosphorylation, the kinase responsible has not been identified.…”

Section: Discussionmentioning

confidence: 64%

Periderm prevents pathological epithelial adhesions during embryogenesis

et al. 2014

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Section: Discussionmentioning

confidence: 64%

Periderm prevents pathological epithelial adhesions during embryogenesis

et al. 2014

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“…The role of Irf6 during development is largely unknown, however its role during epidermal and mammary formation highlights its effect on the cell cycle and cellular differentiation [2], [3], [26]. The decrease in proliferation throughout the Irf6 −/− lingual tissue suggested that (1) Irf6 was acting directly on the SPM in a cell-autonomous fashion to affect cell cycle progression and/or (2) acting in a non-cell-autonomous fashion on the CNC, which then may signal back to the SPM, similar to the results seen in the Wnt1-cre;Tgfbr2 F/F mice.…”

Section: Discussionmentioning

confidence: 99%

Cell-Autonomous and Non-Cell-Autonomous Roles for Irf6 during Development of the Tongue

et al. 2013

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Interferon regulatory factor 6 (IRF6) encodes a highly conserved helix-turn-helix DNA binding protein and is a member of the interferon regulatory family of DNA transcription factors. Mutations in IRF6 lead to isolated and syndromic forms of cleft lip and palate, most notably Van der Woude syndrome (VWS) and Popliteal Ptyerigium Syndrome (PPS). Mice lacking both copies of Irf6 have severe limb, skin, palatal and esophageal abnormalities, due to significantly altered and delayed epithelial development. However, a recent report showed that MCS9.7, an enhancer near Irf6, is active in the tongue, suggesting that Irf6 may also be expressed in the tongue. Indeed, we detected Irf6 staining in the mesoderm-derived muscle during development of the tongue. Dual labeling experiments demonstrated that Irf6 was expressed only in the Myf5+ cell lineage, which originates from the segmental paraxial mesoderm and gives rise to the muscles of the tongue. Fate mapping of the segmental paraxial mesoderm cells revealed a cell-autonomous Irf6 function with reduced and poorly organized Myf5+ cell lineage in the tongue. Molecular analyses showed that the Irf6−/− embryos had aberrant cytoskeletal formation of the segmental paraxial mesoderm in the tongue. Fate mapping of the cranial neural crest cells revealed non-cell-autonomous Irf6 function with the loss of the inter-molar eminence. Loss of Irf6 function altered Bmp2, Bmp4, Shh, and Fgf10 signaling suggesting that these genes are involved in Irf6 signaling. Based on these data, Irf6 plays important cell-autonomous and non-cell-autonomous roles in muscular differentiation and cytoskeletal formation in the tongue.

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“…mammary gland, in pregnant mice (35, 36). Earlier, we showed that maspin is expressed in prostate epithelial cells, Pten +/+ , but not in Pten −/− (16).…”

Section: Resultsmentioning

confidence: 99%

An Essential Role of Maspin in Embryogenesis and Tumor Suppression

Dzinic

Bernardo

et al. 2017

Cancer Research

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Maspin (SerpinB5) is an epithelial-specific tumor suppressor gene product that displays context-dependent cellular functions. Maspin-deficient mouse models created to date have not definitively established maspin functions critical for cancer suppression. In this study, we generated a mouse strain in which exon 4 of the Maspin gene was deleted, confirming its essential role in development but also enabling a breeding scheme to bypass embryonic lethality. Phenotypic characterization of this viable strain established that maspin deficiency was associated with a reduction in maximum body weight and a variety of context-dependent epithelial abnormalities. Specifically, maspin-deficient mice exhibited pulmonary adenocarcinoma, myoepithelial hyperplasia of the mammary gland, hyperplasia of luminal cells of dorsolateral and anterior prostate, and atrophy of luminal cells of ventral prostate and stratum spinosum of epidermis. These cancer phenotypes were accompanied by increased inflammatory stroma. These mice also displayed the autoimmune disorder alopecia aerate. Overall, our findings defined context-specific tumor suppressor roles for maspin in a clinically relevant model to study maspin functions in cancer and other pathologies.

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Temporal and spatial expression patterns for the tumor suppressor Maspin and its binding partner interferon regulatory factor 6 during breast development

Cited by 22 publications

References 29 publications

Periderm prevents pathological epithelial adhesions during embryogenesis

Periderm prevents pathological epithelial adhesions during embryogenesis

Cell-Autonomous and Non-Cell-Autonomous Roles for Irf6 during Development of the Tongue

An Essential Role of Maspin in Embryogenesis and Tumor Suppression

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