Temporal changes of smoking status and motivation among Chinese heroin-dependent, methadone-maintained smokers

Li, Longhui; Liu, Yu; Zhang, Yahai; Beveridge, Thomas J.R.; Zhou, Wenhua

doi:10.1016/j.addbeh.2010.05.003

Cited by 16 publications

(11 citation statements)

References 29 publications

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“…Following stabilization on methadone, the prime motivation for smoking identified by the subjects was tobacco addiction. The study concluded that although nicotine may enhance the high associated with opioids, methadone treatment overall reduced this effect compared to heroin [55]. The opioidnicotine interaction may also be affected by the route of administration of the opioid.…”

Section: Interaction Between Nicotine and Methadonementioning

confidence: 95%

Cigarette Smoking in Methadone Maintained Patients: An Up-to-Date Review

Zirakzadeh¹,

Shuman²,

Stauter³

et al. 2013

CDAR

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Tobacco dependence is the leading cause of preventable death and disability in the United States. While smoking prevalence among U.S. adults is 19.3%, the prevalence of smoking among methadone-maintained patients ranges between 73.5% and 94%. Most methadone-maintained smokers (76%-80%) desire to quit smoking; however only a minority of these smokers receive cessation treatment or referrals for smoking cessation intervention. Smoking cessation treatment in methadone-maintained patients has generally been successful in reducing the daily number of cigarettes smoked. Unfortunately, sustained cessation rates using nicotine replacement therapy and behavioral interventions have generally been low (0%-11%). Poor cessation outcomes may be partially explained by pharmacodynamic interactions between nicotine and methadone leading to increased reinforcement of smoking behavior. Further research is needed to improve smoking cessation rates in methadone-maintained patients.

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Section: Interaction Between Nicotine and Methadonementioning

confidence: 95%

Cigarette Smoking in Methadone Maintained Patients: An Up-to-Date Review

Zirakzadeh¹,

Shuman²,

Stauter³

et al. 2013

CDAR

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“…The opioid withdrawal symptoms are more severe just before next methadone dose. Another factor is that heroin use also increases tobacco smoking [17], and patients seeking methadone maintenance treatment are already smokers before beginning opioid substitution therapy [18]. Admission to methadone maintenance therapy may decrease the number of cigarettes smoked [19].…”

Section: Tobacco Smoking In Methadone-maintained Patientsmentioning

confidence: 99%

“…The reasons for methadone use and concurrent smoking have been studied using surveys [18,90]. Smoking and concurrent use of methadone make each other more enjoyable and provide mutual benefits.…”

Section: The Pharmacokinetic and Pharmacodynamic Interactions Betweenmentioning

confidence: 99%

“…Nicotine may enhance the reinforcing effects of methadone, or nicotine may serve as a conditioned stimulus for methadone selfadministration. The primary motivations for smoking during heroin use differ in nature from those for smoking during methadone use [18]. Heroin users smoke mainly to maintain pleasure, alleviate agitation and sleeping disturbances, and socialize.…”

Section: The Pharmacokinetic and Pharmacodynamic Interactions Betweenmentioning

confidence: 99%

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Methadone’s effect on nAChRs—a link between methadone use and smoking?

Talka

Tuominen

Salminen

2015

Biochemical Pharmacology

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“…9 Several studies have reported the associations between smoking and opioid receptors. [10][11][12][13][14][15] For example, Li et al 16 reported that the prevalence of cigarette smoking is significantly increased in heroin-dependent patients. However, these studies were primarily based on self-report.…”

Section: Introductionmentioning

confidence: 99%

OPRM1 genetic polymorphisms are associated with the plasma nicotine metabolite cotinine concentration in methadone maintenance patients: a cross sectional study

et al. 2012

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Majority of the heroin-dependent patients smoke cigarettes. Although it has been reported that the OPRM1 genetic polymorphism is associated with the brain mu-opioid receptor binding potential in cigarette smokers, there is no direct evidence showing the impact of plasma cotinine, a nicotine metabolite, on treatment responses to methadone maintenance treatment (MMT). In this study, we aimed to test the hypothesis that the genetic polymorphisms in the OPRM1 are associated with the methadone treatment responses and the severity of cigarette smoking directly measured by the plasma concentration of cotinine in a Taiwanese MMT cohort. Fifteen OPRM1 single-nucleotide polymorphisms (SNPs) were selected and genotyped on DNA samples of 366 MMT patients. Plasma concentrations of cotinine were measured by cotinine enzyme-linked immunosorbent assay. The plasma cotinine concentration had positive correlation with concentrations of methadone (P ¼ 0.042) and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine (P ¼ 0.037). Methadone treatment non-responders, defined by a positive urine morphine test, had a higher plasma concentration of cotinine (P ¼ 0.005), but a lower plasma concentration-todose ratio of both R-and S-methadone (P ¼ 0.001 and 0.012, respectively) than the responders. OPRM1 genetic variants, rs1074287, rs6912029, rs1799971, rs12209447, rs510769, rs3798676, rs553202, rs7748401, rs495491, rs10457090, rs589046, rs3778152 and rs563649, were significantly associated with the plasma concentration of cotinine when using recessive model for genotypes (general linear model (GLM), Po0.038; false discovery rate (FDR)o0.035) and additive model for allele types (GLM, Po0.03; FDRo0.049) in association analyses. The G allele carriers of SNP rs1799971 (A118G) on exon 1 of OPRM1 gene had a lower plasma cotinine concentration than the A allele carriers (GLM, P ¼ 0.029). OPRM1 genetic polymorphisms are associated with the plasma concentration of cotinine in a Taiwanese MMT cohort. Carriers with the major allele of SNP rs1799971 had a higher plasma cotinine concentration.

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Temporal changes of smoking status and motivation among Chinese heroin-dependent, methadone-maintained smokers

Cited by 16 publications

References 29 publications

Cigarette Smoking in Methadone Maintained Patients: An Up-to-Date Review

Cigarette Smoking in Methadone Maintained Patients: An Up-to-Date Review

Methadone’s effect on nAChRs—a link between methadone use and smoking?

OPRM1 genetic polymorphisms are associated with the plasma nicotine metabolite cotinine concentration in methadone maintenance patients: a cross sectional study

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