Temporal Factors Affecting the Secondary Critical Ischemia of Normothermic Experimental Skin Flaps

Babajanian, Michel; Zhang, Wen X.; Turk, Jon B.; Weinberg, Hubert; Biller, Hugh F.; Urken, Mark L.

doi:10.1001/archotol.1991.01870240052008

Cited by 9 publications

(8 citation statements)

References 35 publications

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“…A study performed on mouse skin flaps subjected to combinations of primary ischemia, reperfusion, and secondary ischemia revealed that flap survival significantly decreased due to a decreased reperfusion time (the time between primary and secondary ischemia). A longer period of primary ischemia and/or decreased reperfusion time lowers the tolerance of that flap to subsequent ischemic insults and secondary ischemia [ 9 ]. Based on this information, we could describe the ischemia timeline for the scalp in the hair transplant process.…”

Section: Discussionmentioning

confidence: 99%

Feily’s method as a new mode of hair grafting in prevention of scalp necrosis even in dense hair transplantation

Feily

Moeineddin

2015

Dermatol Pract Concept

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Hair restoration is a safe procedure and most of its associated complications are preventable by the surgeon and/or the patient. Recipient area necrosis is rare but arises when an increased number of recipient grafts are utilized and de-vascularization of the scalp occurs. The aim of this study was to investigate and compare all cases and pictures reported in main search engines and Iranian centers of hair transplant to find the dangerous zone of necrosis and to provide a new method for prevention of necrosis. Pictorial analysis of this study revealed that the majority of necrosis (14 of 18) occurs in central region of the scalp and is inclined, particularly, to the right parietal aspect of the scalp. Accordingly, a case series was done and a new method for prevention of scalp necrosis even in dense packing transplantation was discussed.

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Section: Discussionmentioning

confidence: 99%

Feily’s method as a new mode of hair grafting in prevention of scalp necrosis even in dense hair transplantation

Feily

Moeineddin

2015

Dermatol Pract Concept

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“…Ischemia causes rapid depletion of adenosine triphosphate (ATP) and other high‐energy substrates 6‐10 . When energy from these substrates is no longer available, cellular homeostatic mechanisms fail, including the sodium‐potassium pump and calcium storage 9‐11 .…”

Section: Integrated Theory Of No‐reflowmentioning

confidence: 99%

“…Sequestration of calcium stores cannot be maintained, resulting in general intracellular calcium overload 14 . Fluid shifts occur, and the cells swell 8,14‐17 …”

Section: Integrated Theory Of No‐reflowmentioning

confidence: 99%

“…Other changes in the character of intravascular contents also favor vascular occlusion. The extravascular shifting of fluid results in hemoconcentration, predisposing to intravascular sludging 8,31 . The ATP deficit results in decreased erythrocyte deformability, which increases blockage of small vessels by erythrocytes, especially at low flow 32 …”

Section: Integrated Theory Of No‐reflowmentioning

confidence: 99%

“…Activated platelets secrete Thromboxane A 2 (T x A 2 ), serotonin, substance P, and other vasoactive and platelet aggregating substances, and they accelerate thrombin production 42‐45 . Intrinsic thrombolytic/fibrinolytic mechanisms are impaired 8,46,47 . Platelets continue to aggregate into larger clumps, bits break off some clumps to travel distally as microvascular emboli, vessel lumena narrow, and blood flow slows 48,49 …”

Section: Integrated Theory Of No‐reflowmentioning

confidence: 99%

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An Integrated Theory of the No‐Reflow Phenomenon and the Beneficial Effect of Vascular Washout on No‐Reflow

1999

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Microcirculatory events in ischemia/reperfusion of the pancreas defined by continuous tissue oximetry

Benz¹,

Wiessner

Obermaier

et al. 2002

Transplant International

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Temporal Factors Affecting the Secondary Critical Ischemia of Normothermic Experimental Skin Flaps

Cited by 9 publications

References 35 publications

Feily’s method as a new mode of hair grafting in prevention of scalp necrosis even in dense hair transplantation

Feily’s method as a new mode of hair grafting in prevention of scalp necrosis even in dense hair transplantation

An Integrated Theory of the No‐Reflow Phenomenon and the Beneficial Effect of Vascular Washout on No‐Reflow

Microcirculatory events in ischemia/reperfusion of the pancreas defined by continuous tissue oximetry

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