Temporal Lobectomy: Does It Worsen or Improve Presurgical Psychiatric Disorders?

Pintor, Luís

doi:10.1007/7854_2021_224

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Women who used AEDs that activate cytochrome P450 proteins experienced significant decreases in blood, testosterone, and estradiol levels, with higher levels of sex steroid globulin [ 45 ]. Women who used AEDs with the cytochrome P450 protein inhibitor had considerably higher adrenal and gonadal androgens [ 46 ]. WWE who use lamotrigine or gabapentin, two AEDs that do not affect cytochrome P450 proteins, have a hormonal balance that is not different from non-epileptic controls [ 47 , 48 ].…”

Section: Reviewmentioning

confidence: 99%

Epilepsy and Issues Related to Reproductive Health

Khan,

Bankar,

Bandre

et al. 2023

Cureus

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Sexual disorders are prevalent and vary in men and women with epilepsy (WWE). Infertility and reproductive abnormalities are twice as common in females with epilepsy. Antiepileptic medications and seizures can both have an impact on sexual health in people with epilepsy. Seizures can alter the release of pituitary and hypothalamic hormones, and some antiepileptic drugs (AEDs) can alter sex steroid hormones (gonadal steroids and gonad corticoids). Females with epilepsy are more susceptible to menstrual cycle irregularity and polycystic ovary syndrome . Females and males had lower reproductive rates, and the causes are likely psychological and physiological, with epilepsy and AEDs again playing a role. Sexual disorders are common in WWE and men with epilepsy and can be caused by psychological, physical, or social factors. Specialists must address the gender-based biology of epilepsy and the impact of AEDs on sexual well-being to offer the best treatment possible for patients with epilepsy, particularly women of sexual maturity.

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Section: Reviewmentioning

confidence: 99%

Epilepsy and Issues Related to Reproductive Health

Khan,

Bankar,

Bandre

et al. 2023

Cureus

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Role of epilepsy in women’s reproductive function

Orchinskaya,

Degtereva,

Zotova

et al. 2024

V.F.Snegirev Archives of Obstetrics and Gynecology

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According to the World Health Organization, epilepsy is one of the most common neurological diseases in the world, affecting about 50 million people. The overall prevalence of epilepsy in the Russian Federation in 2020 was 2.49 patients per 1,000 people, and the total number of registered epilepsy patients in Russia was 366,134 people. About 40% of epilepsy patients are women of reproductive age. The course of epilepsy in women of reproductive age has its own characteristics, which are associated with daily and monthly cyclic rhythms. Epilepsy has a wide range of physiological consequences due to antiepileptic pharmaceutical therapy. The purpose of the review is to summarize up-to-date information on the impact of epilepsy on women's reproductive health. The authors conducted a search for publications in the electronic databases PubMed, eLibrary and Google Scholar. The search strategy included the presence of the following keywords and their combinations: "epilepsy", "reproductive health", "sex hormones", "pregnancy", "menstrual cycle", "fetal", "neonatal", "epilepsy", "reproductive health", "sex hormones", "pregnancy", "menstrual cycle", "fetal", "neonatal". The search was conducted among studies published before December 2023. Women are particularly concerned about epilepsy throughout their reproductive years. Infertility rates increase as a result of the psychological stress faced by people with epilepsy and impaired physiological processes that support reproductive health. Finally, the doctor should examine the physiological effects of antiepileptic and anticonvulsant drugs. The main goal of therapy is to provide women with epilepsy with a seizure-free life, excellent overall well-being and improved health. The current plan is achievable if the practitioner is familiar with the sexual differences in the course of epilepsy at the molecular level. The limitation is that modern treatment methods cannot be available to every woman in conditions of limited resources.

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Temporal Lobectomy: Does It Worsen or Improve Presurgical Psychiatric Disorders?

Cited by 2 publications

References 67 publications

Epilepsy and Issues Related to Reproductive Health

Epilepsy and Issues Related to Reproductive Health

Role of epilepsy in women’s reproductive function

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