Temporal processing properties of auditory DUM neurons in a bush-cricket

Stumpner, Andreas; Lefebvre, Paule Chloé; Seifert, Marvin; Ostrowski, Tim D.

doi:10.1007/s00359-019-01359-9

Cited by 5 publications

(8 citation statements)

References 71 publications

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“…Negative deflections occurring in the rising flank, interpreted as IPSPs before (Lefebvre et al 2018 ; Stumpner et al 2019 ), were abolished by PTX -application (Fig. 5 a).…”

Section: Resultsmentioning

confidence: 80%

“…At 50 dB SPL, the average tuning broadened following PTX application by 1.99 ± 4.76 kHz (N = 40) and following ringer application by only 0. Negative deflections occurring in the rising flank, interpreted as IPSPs before (Lefebvre et al 2018;Stumpner et al 2019), were abolished by PTX -application (Fig. 5a).…”

Section: Blocking Inhibitionmentioning

confidence: 87%

“…Recording and staining have been described in detail by Lefebvre et al ( 2018 ) and Stumpner et al ( 2019 ). Briefly, the animal was anaesthetized for about 3 min with CO 2 and fixed ventral-side-up to a plastic holder with a wax–resin mixture.…”

Section: Methodsmentioning

confidence: 99%

“…Local auditory DUM neurons with small soma are described for grasshoppers (Stumpner and Ronacher 1991 ; Thompson and Siegler 1991 ) and bush-crickets (Lefebvre et al 2018 ). In the bush-cricket A. nigrovittata a population of at least 15 DUM neurons provides a filter bank for carrier frequency processing (Lefebvre et al 2018 ) and certain temporal parameters (Stumpner et al 2019 ). They have been hypothesized to inhibit local or ascending auditory neurons in the prothoracic ganglion (Lefebvre et al 2018 ), but it has not even been shown that they contain GABA as transmitter so far.…”

Section: Introductionmentioning

confidence: 99%

“…The bush-cricket A. nigrovittata with males and females singing at different carrier frequencies and with different temporal patterns has become a model case for auditory processing. The system has a—for bush-crickets—unusually large number of elements with auditory input in the prothorax (Stumpner and Molina 2006 , Stumpner et al 2019 ). Inhibition obviously plays a prominent role in shaping specific responses (Stumpner 1998 , Molina and Stumpner 2005 ).…”

Section: Introductionmentioning

confidence: 99%

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Auditory DUM neurons in a bush-cricket: inhibited inhibitors

et al. 2020

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Thoracic ganglia of many hearing insects house the first level of auditory processing. In bush-crickets, the largest population of local auditory neurons in the prothoracic processing centre are dorsal unpaired median (DUM) neurons. It has been suggested that DUM neurons are inhibitory using γ-aminobutyric acid (GABA) as transmitter. Immunohistochemistry reveals a population of about 35-50 GABA-positive somata in the posterior medial cluster of the prothoracic ganglion. Only very few small somata in this cluster remain unstained. At least 10 neurites from 10 neurons can be identified. Intracellularly stained auditory DUM neurons have their soma in the cluster of median GABA positive cells and most of them exhibit GABAimmunoreactivity. Responses of certain DUM neurons show obvious signs of inhibition. Application of picrotoxin (PTX), a chloride-channel blocker in insects, changes the responses of many DUM neurons. They become broader in frequency tuning and broader or narrower in temporal pattern tuning. Furthermore, inhibitory postsynaptic potentials (IPSPs) may be replaced by excitatory postsynaptic potentials. Loss of an IPSP in the rising graded potential after PTX-application leads to a significant reduction of first-spike latency. Therefore, auditory DUM neurons receive effective inhibition and are the best candidates for inhibition in DUM neurons and other auditory interneurons.

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“…Negative deflections occurring in the rising flank, interpreted as IPSPs before (Lefebvre et al 2018 ; Stumpner et al 2019 ), were abolished by PTX -application (Fig. 5 a).…”

Section: Resultsmentioning

confidence: 80%

Section: Blocking Inhibitionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Auditory DUM neurons in a bush-cricket: inhibited inhibitors

et al. 2020

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Communication by substrate-borne mechanical waves in insects: From basic to applied biotremology

Strauß

Stritih-Peljhan

Nieri

et al. 2021

Advances in Insect Physiology

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Multielectrode array use in insect auditory neuroscience to unravel the spatio-temporal response pattern in the prothoracic ganglion of Mecopoda elongata

Scherberich,

Stange-Marten,

Schöneich

et al. 2024

Journal of Experimental Biology

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Mechanoreceptors in hearing organs transduce sound-induced mechanical responses into neuronal signals, which are further processed and forwarded to the brain along a chain of neurons in the auditory pathway. Bushcrickets (katydids) have their ears in the front leg tibia and the first synaptic integration of sound-induced neuronal signals takes place in the primary auditory neuropil of the prothoracic ganglion. By combining intracellular recordings of the receptor activity in the ear, extracellular multichannel array recordings on top of the prothoracic ganglion and hook electrode recordings at the neck connective, we mapped the timing of neuronal responses to tonal sound stimuli along the auditory pathway from the ears towards the brain. The use of the multielectrode array allows the observation of spatio-temporal patterns of neuronal responses within the prothoracic ganglion. By eliminating the sensory input from one ear, we investigated the impact of contralateral projecting interneurons in the prothoracic ganglion and added to previous research on the functional importance of contralateral inhibition for binaural processing. Furthermore, our data analysis demonstrates changes in the signal integration processes at the synaptic level indicated by a long-lasting increase in the local field potential amplitude. We hypothesise that this persistent increase of the local field potential amplitude is important for the processing of complex signals, such as the conspecific song.

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Temporal processing properties of auditory DUM neurons in a bush-cricket

Cited by 5 publications

References 71 publications

Auditory DUM neurons in a bush-cricket: inhibited inhibitors

Auditory DUM neurons in a bush-cricket: inhibited inhibitors

Communication by substrate-borne mechanical waves in insects: From basic to applied biotremology

Multielectrode array use in insect auditory neuroscience to unravel the spatio-temporal response pattern in the prothoracic ganglion of Mecopoda elongata

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