Temporal relationships between awakening cortisol and psychosocial variables in inpatients with anorexia nervosa – A time series approach

Wild, Beate; Stadnitski, Tatjana; Wesche, Daniela; Stroe-Kunold, Esther; Rudofsky, Gottfried; Maser-Gluth, Christiane; Herzog, Wolfgang; Friederich, Hans‐Christoph

doi:10.1016/j.ijpsycho.2016.03.002

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…Patients were informed about the study and written consent was obtained during the first week of inpatient stay. In total, 28 AN patients were enrolled (Note: A subgroup of these patients were subjects in previous investigations of the cortisol awakening response in AN patients [ 16 ] and in the time series of awakening cortisol [ 17 ]. Findings of this study regarding leptin have been previously published [ 18 ]).…”

Section: Methodsmentioning

confidence: 99%

Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment

et al. 2017

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ObjectiveThe protein hormone adiponectin promotes metabolic and psychological health. The aim of the study was to track changes in adiponectin levels in response to weight gain and to assess associations between adiponectin and psychological aspects in patients with anorexia nervosa (AN).MethodsTo investigate if adiponectin levels depend on AN severity, data were assessed from 11 inpatients with a very low body mass index (BMI) and a high chronicity (high severity group; HSS), and nine with less severe symptoms (LSS). During the course of treatment, serum adiponectin concentrations were assessed on a weekly basis along with BMI. Psychological variables (i.e., depression, anxiety, stress, and AN-specific symptoms) were obtained by means of electronic diaries. Longitudinal regressions and correlations were calculated to evaluate the temporal course of adiponectin and its relationship with psychological self-ratings.ResultsAt the beginning adiponectin was not increased in HSS patients (p = .56), and only marginally elevated in LSS patients (p = 0.07) compared with controls. In HSS patients, adiponectin increased along with BMI during the first treatment phase (i.e., when the BMI of patients was below 16 kg/m2) and thereafter decreased with further weight gain. In LSS patients, adiponectin was not associated with BMI increase. Furthermore, adiponectin was strongly negatively correlated with psychological self-ratings when the BMI of patients was above 16 kg/m2, i.e., higher levels of adiponectin were related to lower ratings of depression, anxiety, and AN-specific symptoms.DiscussionThe study connects previous varying results by indicating that the course of adiponectin is dependent on BMI and symptom severity. Similarly, associations of adiponectin and psychological health depended on BMI.

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Section: Methodsmentioning

confidence: 99%

Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment

et al. 2017

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“…A much debated question is whether salivary cortisol could be used as a susceptibility marker for PTSD patients [ 20 ]. Studies investigating salivary cortisol as a susceptibility marker for PTSD patients have produced different results [ 12 ], which may be attributed to the differences in investigation time, sampling time, type of trauma, assessment tools for PTSD symptoms, and collection and analysis of salivary cortisol [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Salivary cortisol in post-traumatic stress disorder: a systematic review and meta-analysis

et al. 2018

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BackgroundStudies investigating salivary cortisol level as susceptibility marker for post-traumatic stress disorder (PTSD) produced inconsistent results. The aim of this study was to compare salivary cortisol concentration levels in PTSD patients with those in controls by synthesizing published data.MethodsWe did a systematic review, meta-analysis and meta-regression of studies comparing concentrations of salivary cortisol between patients with PTSD and controls. The electronic databases of PubMed, Embase, Web of Science and Psyc-ARTICLES were searched for relevant articles. A random-effects model with restricted maximum-likelihood estimator is used to synthesize the effect size (assessed by standardized mean difference).ResultsA total of 784 articles were identified of which 22 were included in the final analysis. A trend of lower salivary cortisol levels was found in PTSD patients when compared with the controls (SMD = − 0.28, 95% CI-0.53;-0.04, p = 0.022). Subgroup analysis showed that the salivary cortisol levels were lower in patients with PTSD than in controls in studies conducted after 2007 or in studies using saliva samples collected in the morning.ConclusionsThe evidence from this meta-analysis supports that salivary samples collected in the morning consistently showed a lower salivary cortisol level in patients with PTSD than in controls, although whether salivary cortisol could be used as a diagnostic tool requires further research.Electronic supplementary materialThe online version of this article (10.1186/s12888-018-1910-9) contains supplementary material, which is available to authorized users.

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“…In total, 28 AN patients were enrolled. Please note that a subgroup of these patients were subjects in previous investigations of the cortisol awakening response in AN patients [20] and of the time series of awakening cortisol [25]. …”

Section: Methodsmentioning

confidence: 99%

Time Course of Leptin in Patients with Anorexia Nervosa during Inpatient Treatment: Longitudinal Relationships to BMI and Psychological Factors

Stroe-Kunold¹,

Buckert²,

Friederich³

et al. 2016

PLoS ONE

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BackgroundLeptin, a hormone secreted by adipose tissue, appears to play a major role in the homeostasis of body weight and psychobiological processes associated with anorexia nervosa (AN). However, there is scarce data on its exact influence on this disorder, in particular data over time.ObjectiveThe present study addresses whether leptin changes during inpatient treatment play a role for treatment outcome and psychological factors in underweight AN patients.MethodsIn order to understand whether leptin’s role differs in relation to AN severity, data were assessed from 11 patients with a very low BMI and a higher chronicity (high severity group; HSS; mean BMI at the beginning of the study = 13.6; mean duration of illness = 5.1 years) vs. nine with less severe symptoms (LSS; mean BMI = 16.2; mean duration of illness = 3.7 years). During the course of treatment, serum leptin concentrations were assessed weekly while weight (BMI) was assessed twice per week. Concomitantly, psychological variables were obtained by means of electronic diaries. Unconditional linear growth models were calculated to evaluate the temporal course of leptin in relation to BMI. For HSS patients, two phases of treatment (BMI < 16 and BMI ≥ 16 kg/m2) were investigated.ResultsLeptin increased significantly with BMI in both groups of patients. For HSS patients, the increase of leptin in the first treatment phase did not predict later increases in BMI. Furthermore, the relationship of leptin and psychological factors was modulated by symptom severity. In HSS patients, higher leptin levels were associated with greater feelings of depression, anxiety, and stress whereas in LSS patients a higher leptin level showed the trend to be associated with lower psychological symptom burden.ConclusionsOur results suggest that leptin changes are differently associated with weight gain and psychological symptoms depending on the severity of starvation.

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Temporal relationships between awakening cortisol and psychosocial variables in inpatients with anorexia nervosa – A time series approach

Cited by 10 publications

References 25 publications

Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment

Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment

Salivary cortisol in post-traumatic stress disorder: a systematic review and meta-analysis

Time Course of Leptin in Patients with Anorexia Nervosa during Inpatient Treatment: Longitudinal Relationships to BMI and Psychological Factors

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