Temporal trends in bisphenol exposures and associated health risk among Japanese women living in the Kyoto area from 1993 to 2016

Lyu, Zhaoqing; Harada, Kouji H.; Kim, Sung-Min; Fujitani, Tomoko; Hitomi, Toshiaki; Pan, Rui; Park, Na-Youn; Fujii, Yukiko; Kho, Younglim; Choi, Kyungho

doi:10.1016/j.chemosphere.2023.137867

Cited by 12 publications

(4 citation statements)

References 38 publications

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“…According to that, the relevant HBGV must be updated to meet the current human health risk assessment standards (such as the TDI for the calculation of phenol-specific HQs should be updated) ( 101 ). Additionally, the HI values were < 1 (sum of the corresponding HQs of each bisphenol), and this finding is consistent with those of recent studies ( 33 , 103 ), although some of these values were set many years ago ( 83 ).…”

Section: Discussionsupporting

confidence: 91%

“…To assess PCP use by the different age groups, the Mann–Whitney U and Kruskal–Wallis tests were performed. The summary metric for BPs (ΣBPs) was calculated by summarizing the molar concentrations of the measured BPs ( 33 , 64 , 68 ). All bisphenol measurements, including the molar sum, were divided by urinary creatinine to adjust for urine dilution.…”

Section: Methodsmentioning

confidence: 99%

“…However, some other substitutes of BPA have been regularly detected in human urine samples, including BPF and BPS ( 32 ). BPF has been the most important risk driver since 2000 in Japan ( 33 ), whereas BPS concentrations increased every year in Australia from 2012 to 2017 ( 34 ), suggesting that BPF and BPS have become a BPA replacement. Notably, most animal studies have reported that BPA and its substitutes (e.g., BPF and BPS) disturb the reproductive neuroendocrine system ( 35 ), increasing the risk of endocrine disruption ( 36 ).…”

Section: Introductionmentioning

confidence: 99%

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Exposure characteristics and cumulative risk assessment of bisphenol A and its substitutes: the Taiwan environmental survey for toxicants 2013

Lin,

Chen,

Chang

et al. 2024

Front. Public Health

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IntroductionEver since the use of bisphenol A (BPA) has been restricted, concerns have been raised regarding the use of its substitutes, such as bisphenol S (BPS) and bisphenol F (BPF). Meanwhile, the EU European Food Safety Authority (EFSA) issued the new tolerable daily intake (TDI) after the latest re-risk assessment for BPA, which enforced the need for cumulative risk assessment in the population. This study was conducted to identify BPA and its substitute’s exposure characteristics of the general Taiwanese population and estimate the cumulative risk of bisphenol exposure.MethodsUrine samples (N = 366 [adult, 271; minor, 95]) were collected from individuals who participated in the Taiwan Environmental Survey for Toxicants 2013. The samples were analyzed for BPA, BPS, and BPF through ultraperformance liquid chromatography–tandem mass spectrometry. Daily intake (DI) levels were calculated for each bisphenol. Hazard quotients (HQs) were calculated with the consideration of tolerable DI and a reference dose. Additionally, hazard index (HI; sum of HQs for each bisphenol) values were calculated.ResultsOur study found that the median level of BPA was significantly higher in adults (9.63 μg/g creatinine) than in minors (6.63 μg/g creatinine) (p < 0.001). The DI of BPS was higher in female (0.69 ng/kg/day) than in male (0.49 ng/kg/day); however, the DIs of BPF and BPS were higher in boys (1.15 and 0.26 ng/kg/day, respectively) than in girls (0.57 and 0.20 ng/kg/day, respectively). Most HI values exceeded 1 (99% of the participants) after EFSA re-establish the TDI of BPA.DiscussionOur study revealed that the exposure profiles and risk of BPA and its substitute in Taiwanese varied by age and sex. Additionally, the exposure risk of BPA was deemed unacceptable in Taiwan according to new EFSA regulations, and food contamination could be the possible source of exposure. We suggest that the risk of exposure to BPA and its substitutes in most human biomonitoring studies should be reassessed based on new scientific evidence.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exposure characteristics and cumulative risk assessment of bisphenol A and its substitutes: the Taiwan environmental survey for toxicants 2013

Lin,

Chen,

Chang

et al. 2024

Front. Public Health

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show abstract

“…A value of 4 μg/kg bw/day for the tolerable daily intake (TDI) of BPA was used in the study [ 19 ]. The TDI values for BPS, BPF, and TBBPA were 4.4, 3.5, and 1000 μg/kg bw/day, respectively [ 20 , 21 ], while TDIs for other BPs are not available.…”

Section: Methodsmentioning

confidence: 99%

Bisphenol Chemicals in Surface Soil from E-Waste Dismantling Facilities and the Surrounding Areas: Spatial Distribution and Health Risk

Zhao,

Zhou,

Wang

et al. 2024

Toxics

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Electronic waste (e-waste) dismantling facilities are well-known bisphenol chemical (BP) sources. In this study, non-targeted screening combined with targeted analysis of BPs in surface soil from e-waste dismantling facilities and their surroundings revealed their presence, distribution, and exposure risk. A total of 14 BPs were identified including bisphenol A (BPA) and its novel structural analogs and halogenated BPs. The total concentrations of BPs ranged from 963 to 47,160 ng/g (median: 6970 ng/g) in e-waste soil, higher than those measured in surface soil from surrounding areas, i.e., 10–7750 ng/g (median 197 ng/g). BPA, tetrabromobisphenol A (TBBPA), and bisphenol F (BPF) were the dominant ones from the two areas. Concentrations of TBBPA and its debromination product from the surrounding area significantly decreased with increasing distances from the e-waste dismantling facilities. Estimation of daily intake via oral ingestion of soil suggests that current contamination scenarios are unlikely to pose health risks for e-waste dismantling workers and adults and toddlers living in the surrounding areas, with their intakes generally well below the tolerable daily intakes proposed for several BPs. However, the BPA intakes of workers exceeded the more strict tolerable daily intake for BPA established recently, which merits continuous environmental surveillance.

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Temporal trends in exposure to parabens, benzophenones, triclosan, and triclocarban in adult females in Kyoto, Japan, from 1993 to 2016

Yoshida,

Lyu,

Kim

et al. 2024

Environ Sci Pollut Res

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Temporal trends in bisphenol exposures and associated health risk among Japanese women living in the Kyoto area from 1993 to 2016

Cited by 12 publications

References 38 publications

Exposure characteristics and cumulative risk assessment of bisphenol A and its substitutes: the Taiwan environmental survey for toxicants 2013

Exposure characteristics and cumulative risk assessment of bisphenol A and its substitutes: the Taiwan environmental survey for toxicants 2013

Bisphenol Chemicals in Surface Soil from E-Waste Dismantling Facilities and the Surrounding Areas: Spatial Distribution and Health Risk

Temporal trends in exposure to parabens, benzophenones, triclosan, and triclocarban in adult females in Kyoto, Japan, from 1993 to 2016

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