Temporal Trends in Clinical Characteristics, Management and Prognosis of Patients With Symptomatic Heart Failure in Japan　– Report From the CHART Studies –

Transtubular Potassium Concentration Gradient as a Surrogate Measure of Arterial Underfilling in Acute Decompensated Heart Failure

“…Cardiovascular death or hospitalization for HF in Japanese patients with HFrEF is more frequent than in patients with HFpEF, according to a recent CHART-2 study. 13 The present study also identified an independent relationship between higher dose of loop diuretics and cardiac event occurrence, which corroborates previous findings of a significant dose-dependent association between chronic use of loop diuretics and worsening prognosis in Japanese patients with chronic HF. 14 The present findings should be interpreted in consideration of the following limitation.…”

Recent Progress and Next Challenges in the Treatment of Symptomatic Heart Failure in Japan

“…3 One of the major and important findings in this report is the improved long-term prognosis in symptomatic CHF patients from the recent widespread use of evidence-based therapy. At the same time, the report also reveals the increased prevalence of lifestyle-related tial benefit of the use of statins for the treatment of HFpEF.…”

Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART‐2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study

“…CHART‐2 data that support the findings of this study are available from the corresponding author on reasonable request. The CHART‐2 study has been described in detail previously . Briefly, CHART‐2 (n=10219) is a multicenter, prospective, observational cohort study designed to identify the characteristics, mortality, and prognostic risks of patients with a history of HF and those without HF but at high risk of HF in Japan .…”

“…The CHART‐2 study has been described in detail previously . Briefly, CHART‐2 (n=10219) is a multicenter, prospective, observational cohort study designed to identify the characteristics, mortality, and prognostic risks of patients with a history of HF and those without HF but at high risk of HF in Japan . From October 2006 to March 2010, 10219 consecutive stable patients at outpatient clinics or just before discharge aged >20 years were successfully enrolled in CHART‐2 if they had stage B, C, or D HF or significant coronary artery disease in stage A, as defined according to the ACC/AHA guidelines .…”