Temporal trends in the risk of second primary cancers among survivors of adult‐onset cancers, 1980 through 2013: An Australian population‐based study

Ye, Yuanzi; Otáhal, Petr; Wills, Karen; Neil, Amanda L.; Venn, A

doi:10.1002/cncr.31247

Cited by 15 publications

(12 citation statements)

References 23 publications

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“…We observed that patients with EC-LUSC and EC-LUAD were more often diagnosed in recent years (2010 to 2016) compared to patients with LC-1.These results might be attributed to the improvement of diagnostic technique over time and shorter follow-up intervals of EC patients. In fact, some researches con rmed that cancer survivors received more frequent screening for various subsequent primary cancers than patients without a history of cancer [22][23][24]. The fact that cancer survivors might receive better surveillance for new cancers also explained why individuals with previous EC tended to diagnosed at an earlier stage compared with LC-1 individuals in this study, which was consistent with previous study [25].…”

Section: Patient and Tumor Characteristicssupporting

confidence: 91%

Secondary Primary Lung Cancer After Esophageal Cancer: A Population-Based Study of 44,172 Patients

Gao

Qiu

et al. 2020

Preprint

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Background: The present study aimed to assess the incidence, characteristics, and survival of secondary primary lung cancer after primary esophageal cancer (EC-LC). Methods: The patients with esophageal cancer (EC) who developed SPLC and patients with first primary lung cancer (LC-1) were retrospectively reviewed in the Surveillance, Epidemiology, and End Results 18 registries covering 2000 to 2016. The risk of secondary primary lung cancer using standardized incidence ratio (SIR) was calculated among patients with EC. Overall survival and characteristics were compared between patients with EC-LC and patients with LC-1.Results: In comparison with the general population, the patients with EC had a higher risk for developing secondary primary lung cancer (SIR =1.86, 95% confidence interval (CI): 1.69-2.05). There was a significant difference with regard to the year of diagnosis, sex, grade and stage between the secondary primary lung squamous carcinoma after EC (EC-LUSC) and first primary lung squamous carcinoma (LUSC-1) patients. A statistically significant difference with respect to race, sex, age, year, grade and stage was found between the secondary primary lung adenocarcinoma after EC (EC-LUAD) and first primary lung adenocarcinoma (LUAD-1) patients. A history of EC was found to be an independent risk factor of death for lung squamous carcinoma and lung adenocarcinoma patients in localized stage based on multivariate Cox regression analysis, propensity score-matching analysis and multiple imputation.Conclusion: There is a significantly increased risk of secondary primary lung cancer in EC survivors and a history of EC adversely affects overall survival in individuals who subsequently develop localized EC-LUSC and EC-LUAD. Clinicians should moderately strengthen lung tissue protection during the management of EC patients.

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Section: Patient and Tumor Characteristicssupporting

confidence: 91%

Secondary Primary Lung Cancer After Esophageal Cancer: A Population-Based Study of 44,172 Patients

Gao

Qiu

et al. 2020

Preprint

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“…As our study cohorts were retrospectively collected within a long period, it is likely the risk of SPC was influenced by the secular trends of anticancer therapies. Improved screening and treatment strategies may have greatly prolonged patients' survival and thus lead to higher risk of exposure to a subsequent cancer [38]. Besides, the validity of our proposed nomogram needs further exploration in other population-based datasets.…”

Section: Discussionmentioning

confidence: 99%

Life-long follow-up of second primary lung and extra-pulmonary cancer in lung cancer patients is needed

Ma¹,

Qin²,

Zhang³

et al. 2020

J. Cancer

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Background: Lung cancer (LC) patients are at high risk of developing second primary cancer (SPC). This study aimed to explore the risk factors associated with SPC and provide an individualized risk prediction model for LC patients. Methods: Initial primary lung cancer (IPLC) patients diagnosed between 1998 and 2011 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. A Fine-Gray multivariate competing-risk model was used to estimate the risk of SPC, and the model was assessed regarding discrimination and calibration. A nomogram was designed for clinical convenience to predict the 3-, 5-, and 10-year probabilities of developing SPCs. Results: A total of 142,491 IPLC patients were considered in this study and 14,374(10.01%) developed SPC within a maximum study period of approximately 19 years. Seven independent prognostic factors were identified according to the competing-risk model, and the SEER summary stage and surgery were the strongest predictors. The model was well calibrated and had good discrimination ability(C-index = 0.746). Conclusions: LC survivors had an increased risk of SPC and factors associated with good prognosis often predicted SPC. Consideration should be given to increasing the duration of routine follow-up even after 10 years of initial diagnosis for those at the highest risk and site-specific follow-up strategy is also required.

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“…A growing number of patients are surviving from cancer because of the increased survival as well as the advances in cancer screening programs and novel treatments [ 1 – 3 ]. However, all cancer survivors are at risk for developing a second primary cancer [ 4 – 6 ]. It was reported that the incidence of second malignant neoplasm (SMN), calculated from the Surveillance, Epidemiology, and End Results (SEER) Program, was approximately 8.1% between 1992 and 2008 in the United States, indicating that nearly 1 in 12 cancer patients can develop a SMN [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Suicide among Cancer Survivors Who Developed a Second Malignant Neoplasm

Yang

Shang

et al. 2022

Computational Intelligence and Neuroscience

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Background. Cancer diagnosis entails substantial psychological distress and is associated with dramatically increased risks of suicidal behaviors. However, little is known about the suicide risk among cancer survivors who developed a second malignant neoplasm (SMN). Methods. Using the Surveillance, Epidemiology, and End Results database, we conducted a population-based cohort study involving 7,824,709 patients with first malignant neoplasm (FMN). We measured the hazard ratios (HRs) of suicide death after receiving a SMN diagnosis using Cox proportional hazard models, as compared with patients with FMN. The comparison with the US population was achieved by calculating standardized mortality ratios (SMRs). Results. Totally 685,727 FMN patients received a diagnosis of SMN during follow-up, and we in total identified 10,930 and 937 suicide deaths among FMN and SMN patients, respectively. The HR of suicide deaths was 1.23 (95% confidence interval (CI), 1.14–1.31) after a SMN diagnosis, compared with FMN patients, after adjusting for sociodemographic factors, tumor characteristics, and cancer treatment. As compared with the general population, while both SMN and FMN patients suffered an increased risk of suicide deaths, the excess risk was higher among SMN patients than FMN patients (age-, sex-, and calendar-year-adjusted SMR 1.65 (95% CI 1.54–1.75) vs. 1.29 (95% CI 1.26–1.31); P difference < 0.0001 ). Notably, across different time periods, we observed the greatest risk elevation during the first 3 months after a cancer diagnosis. Conclusions. Compared with either patients with FMN or the general population, cancer survivors who received a SMN diagnosis were at increased risk of suicide death. The risk elevation was most prominent soon after the cancer diagnosis, highlighting the necessity of providing timely psychological support to cancer survivors with a SMN.

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Temporal trends in the risk of second primary cancers among survivors of adult‐onset cancers, 1980 through 2013: An Australian population‐based study

Cited by 15 publications

References 23 publications

Secondary Primary Lung Cancer After Esophageal Cancer: A Population-Based Study of 44,172 Patients

Secondary Primary Lung Cancer After Esophageal Cancer: A Population-Based Study of 44,172 Patients

Life-long follow-up of second primary lung and extra-pulmonary cancer in lung cancer patients is needed

Increased Risk of Suicide among Cancer Survivors Who Developed a Second Malignant Neoplasm

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