2018
DOI: 10.21767/2248-9215.100070
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Temporal Variation in Murine Kidney Toxicity to the Antituberculosis Agent (Isoniazid)

Abstract: Background: Isoniazid is a drug largely used for both the treatment and prophylaxis of Tuberculosis. In this study, we investigated whether INH-induced nephrotoxicity is influenced by dosing-time. Materials and Methods:A potentially toxic INH dose (120 mg/kg) was injected by i.p. route to different groups of animals at three different circadian times: 1, 9 and 17 hours after light onset (HALO). INH administration at 1 and 9 HALO resulted in maximum and minimum nephrotoxicity respectively. Toxicity was assessed… Show more

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