Temporomandibular joint disc replacement made by tissue-engineered growth of cartilage

Puelacher, Wolfgang; Wisser, James; Vacanti, Charles A.; Ferraro, Nalton; Jaramillo, Diego; Vacanti, Joseph P.

doi:10.1016/0278-2391(94)90538-x

Cited by 127 publications

(68 citation statements)

References 28 publications

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“…2 Tissue engineering is a potential solution to assist in the healing of this poorly studied structure. 3 While pioneering tissue engineering studies exist for the TMJ disc, [4][5][6][7] it is critical that the detailed standards of native disc properties are determined to advance our tissue engineering efforts. 8 An early study in TMJ anatomy reported that the majority of the cells of the human TMJ disc were fibrocytes with occasional groups of rounder cells.…”

Section: Conclusion-mentioning

confidence: 99%

Cell Type and Distribution in the Porcine Temporomandibular Joint Disc

Detamore¹,

Hegde²,

Wagle³

et al. 2006

Journal of Oral and Maxillofacial Surgery

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Purpose-Surprisingly little is known about the cellular composition of the temporomandibular joint (TMJ) disc, which is a crucial piece of the puzzle in tissue engineering efforts. Toward this end, cell types were identified and quantified regionally in the TMJ disc.Materials and Methods-Porcine TMJ discs were examined by histology, electron microscopy, and immunohistochemistry. Histology consisted of hematoxylin and eosin staining to identify regional variation of cell type and cell numbers. Transmission electron microscopy was used to elucidate differences in organelle content and pericellular matrix between TMJ disc cells and chondrocytes from hyaline cartilage. Immunohistochemistry was used to assess the presence of smooth and skeletal muscle character in the TMJ disc.Results-The overall ratio of fibroblasts to chondrocyte-like cells in the TMJ disc was approximately 2.35 to 1, with the highest relative number of chondrocyte-like cells in the intermediate zone. Electron microscopy revealed distinct differences between TMJ disc chondrocyte-like cells and chondrocytes from hyaline cartilage with respect to organelles and the

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Section: Conclusion-mentioning

confidence: 99%

Cell Type and Distribution in the Porcine Temporomandibular Joint Disc

Detamore¹,

Hegde²,

Wagle³

et al. 2006

Journal of Oral and Maxillofacial Surgery

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“…Although TMJ tissue engineering 27,37,104 is a relatively new field with only a handful of tissue engineering studies available for the TMJ disc [6][7][8][9][10]13,28,29,41,79,86,99 and mandibular condyle, [2][3][4][5]24,25,32,44,45,63,82,83,101,106,108 the number of researchers in the field is growing exponentially as investigators in related fields are discovering a new application for their existing orthopaedic tissue engineering strengths. With more researchers joining the TMJ tissue engineering effort, it is crucial that they are aware of TMJ-specific concerns and understand the pressing questions that exist today.…”

Section: Tissue Engineering Sessionmentioning

confidence: 99%

A Call to Action for Bioengineers and Dental Professionals: Directives for the Future of TMJ Bioengineering

2007

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Abstract-The world's first TMJ Bioengineering Conference was held May 25-27, 2006, in Broomfield, Colorado. Presentations were given by 34 invited speakers representing industry, academics, government agencies such as NIH, and private practice, which included surgeons, engineers, biomedical scientists, and patient advocacy leaders. Other attendees included documentary film makers and FDA officials. The impetus for the conference was that the field of TMJ research has been lacking continuity, with no open forum available for surgeons, scientists, and bioengineers to exchange scientific and clinical ideas and identify common goals, strengths, and capabilities. The goal was thus to plant the seeds for establishing a forum for multidisciplinary and interdisciplinary interactions. The collective wisdom and interactions brought about by a melting pot of these diverse individuals has been pooled and is disseminated in this article, which offers specific directives to bioengineers, basic scientists, and medical and dental professionals including oral and maxillofacial surgeons, pain specialists, orthodontists, prosthodontists, endocrinologists, rheumatologists, immunologists, radiologists, neurologists, and orthopaedic surgeons. A primary goal of this article was to attract researchers across a breadth of research areas to lend their expertise to a significant clinical problem with a dire need for new talent. For example, researchers with expertise in finite element modeling will find an extensive list of clinically significant problems. Specific suggestions for TMJ research were presented by the leading organizations for TMJ surgeons and TMJ patients, and further research needs were identified in a series of group discussions. The specific needs identified at the conference and presented here will be essential for those who endeavor to engage in TMJ research, especially in the areas of tissue engineering and biomechanics. Collectively, it is our hope that many of the questions and directives presented here find their way into the proposals of multidisciplinary teams across the world with new and promising approaches to diagnose, prevent and treat TMJ disorders.

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“…15 biyobozunur poliglikolik asit (PGA) ve polilaktik asit (PLA) fiberlerini kullandılar. Bu baş-langıç girişimleri TME disk mühendisliğinin uygulanabilirliliğini gösterdi.…”

Section: Introductionunclassified

Temporomandi̇bular Eklem Tami̇r Ve Rejenerasyonunda Doku Mühendi̇sli̇ği̇ Uygulamalari

OYAR¹

2016

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Temporomandibular joint disc replacement made by tissue-engineered growth of cartilage

Cited by 127 publications

References 28 publications

Cell Type and Distribution in the Porcine Temporomandibular Joint Disc

Cell Type and Distribution in the Porcine Temporomandibular Joint Disc

A Call to Action for Bioengineers and Dental Professionals: Directives for the Future of TMJ Bioengineering

Temporomandi̇bular Eklem Tami̇r Ve Rejenerasyonunda Doku Mühendi̇sli̇ği̇ Uygulamalari

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