Temporomandibular Joint Involvement in Association With Quality of Life, Disability, and High Disease Activity in Juvenile Idiopathic Arthritis

Frid, Paula; Nordal, Ellen; Bovis, Francesca; Giancane, Gabriella; Larheim, Tore A.; Rygg, Marite; Marafon, Denise Pires; Angelis, Donato De; Palmisani, Elena; Murray, Kevin; Oliveira, Sheila Knupp Feitosa de; Simonini, Gabriele; Corona, Fabrizia; Davidson, J; Foster, Helen; Steenks, M.H.; Flatø, Berit; Zulian, Francesco; Baildam, Eileen; Saurenmann, Rotraud K.; Lahdenne, Pekka; Ravelli, Angelo; Martini, Alberto; Pistorio, Angela; Ruperto, Nicolino

doi:10.1002/acr.23003

Cited by 63 publications

(52 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…JIA is a heterogeneous group of arthritic diseases with an incidence rate of 1 or 2 cases per 1,000 persons worldwide (Schneider and Passo, ). JIA is characterized by chronic inflammation of the joints throughout the body, which can result in joint degradation (Frid et al, ). All joints can be affected, including the temporomandibular joint (TMJ) (Weiss et al, ).…”

mentioning

confidence: 99%

Cyclic Tensile Strain Reduces TNF‐α Induced Expression of MMP‐13 by Condylar Temporomandibular Joint Cells

Tabeian

Bakker

Betti

et al. 2017

Journal Cellular Physiology

View full text Add to dashboard Cite

To investigate whether the disproportionate degradation of mandibular condyle cartilage in arthritic juvenile temporomandibular joint (TMJ) is related to distinctive responses of TMJ-derived cells to tumor necrosis factor-α (TNF-α), and whether mechanical loading affects this response. The effect of TNF-α (0.1-10 ng/ml) was tested on juvenile porcine TMJ cells isolated from the condyle, fossa, and disc, grown in 3D agarose gels. Expression of anabolic and catabolic factors was quantified by RT-qPCR and/or immunohistochemistry. Condylar cells were stimulated for 12 h with TNF-α (10 ng/ml), followed by 8 h of 6% cyclic tensile strain, and gene expression of MMPs was quantified. TNF-α (10 ng/ml) reduced the expression of the matrix proteins collagen types I and II after 6 h of incubation. Aggrecan gene expression was increased in the presence of 0.1 ng/ml TNF-α. The fossa and disc cells responded to TNF-α with an increased expression of the aggrecanase ADAMTS4. TNF-α enhanced MMP-13 gene and protein expression only by condylar cells. Mechanical loading reduced this effect. Cells isolated from the different cartilaginous structures reacted differently to TNF-α. Since the disc and fossa contain a very low level of proteoglycans in comparison to the condyle, the role played by ADAMTS4 in degradation of the fossa and disc might be limited. TNF-α induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle. Since this expression was reduced by mechanical loading, functional loading with oral physiotherapy or orthodontic activators may help to reduce the catabolic effect of TNF-α. J. Cell. Physiol. 232: 1287-1294, 2017. © 2016 Wiley Periodicals, Inc.

show abstract

mentioning

confidence: 99%

Cyclic Tensile Strain Reduces TNF‐α Induced Expression of MMP‐13 by Condylar Temporomandibular Joint Cells

Tabeian

Bakker

Betti

et al. 2017

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…Untreated TMJ arthritis is particularly concerning in pediatric patients because a mandibular growth center is located directly beneath the thin fibrocartilage of the condylar head, making it particularly susceptible to arthritic damage [29]. Such damage can result in mandibular growth restriction, micrognathia, clockwise rotation of the mandible, anterior open bite, malocclusion, and facial asymmetry [19,[30][31][32][33], and negatively effects quality of life [16]. In the current study, CBCT imaging demonstrated TMJ abnormalities in 55% of joints, with at least one abnormal joint in 14 of 21 patients (67%).…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory TMJ arthritis can result in pain, functional limitation, occlusal instability, facial asymmetry and dentofacial deformity that may require operative correction [14,15]. TMJ arthritis has been shown to have a significant adverse impact on physical and psychosocial well-being of children with JIA when compared to those without TMJ involvement [16]. Inflammatory arthritis of the TMJ is often asymptomatic in its early stages [2,3,[6][7][8][9][10][11][12][13], even during times when active synovitis is identified on imaging [17], rendering physical examination insufficient for diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Frequency and Morbidity of Temporomandibular Joint Involvement in Adult Patients With a History of Juvenile Idiopathic Arthritis

Resnick

Dang

Henderson

et al. 2017

Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

“…When the TM complex is compromised, there is the potential for a wide variety of symptoms. Because a Temporomandibular Disorder can give rise to so many variable symptoms, making a proper diagnosis is rather dif icult [6]. The Temporomandibular Joint apparatus does not stand by itself, but is rather part of a highly balanced orthopaedic system including the head, neck, and shoulder regions.…”

Section: Temporomandibular Disorder: Do You Have Tmj?mentioning

confidence: 99%

TMD and pregnancy?

Bayramova¹

2017

Clin J Obstet Gynecol

View full text Add to dashboard Cite

Pregnancy is a happy stage in life of every woman, but at the same time it is a rather diffi cult period, since pregnancy represents a serious strain on the body. In the body of a woman during this period there are signifi cant physiological changes that ensure the correct development of the fetus, prepare the body for the upcoming delivery. In this diffi cult period, the burden on all organs and systems of the woman's body is signifi cantly increased. Especially often suffer joints; there is a risk of permanent pain, the development of diseases or exacerbation of existing diseases. One of the most common problems is Temporomandibular Dysfunction or Disorder (TMD) which many women face, but still hasn't been explained. Review ReviewOften the term TMJ is being used instead of TMD. In actuality, using the phrase "You have TMJ" is inaccurate. TMJ is neither a disease nor syndrome. It is the joint in front of your ear that allows the jaw to move. TMJ=Temporomandibular Joint TMD=Temporomandibular Dysfunction or DisorderThe temporomandibular joint (TMJ) is formed by the articulation of the mandible and the temporal bone of the cranium. It is located anteriorly to the tragus of the ear, on the lateral aspect of the face. The temporomandibular joint (TMJ) acts like a sliding hinge, connecting your jawbone to your skull. You have one joint on each side of your jaw [1]. TMJ disorders-a type of temporomandibular disorder or TMD-can cause pain in your jaw joint and in the muscles that control jaw movement (Figure 1).TMD is a failure of coordinated joint activity due to impaired occlusion of teeth, the location of the TMJ and muscle function. Occurs in 25-30% of the population, in women 3-5 times more often than men. The peak incidence falls on the age of 20-40 years which is the reproductive period for women. The pathophysiology of TMD is the

show abstract

Temporomandibular Joint Involvement in Association With Quality of Life, Disability, and High Disease Activity in Juvenile Idiopathic Arthritis

Cited by 63 publications

References 42 publications

Cyclic Tensile Strain Reduces TNF‐α Induced Expression of MMP‐13 by Condylar Temporomandibular Joint Cells

Cyclic Tensile Strain Reduces TNF‐α Induced Expression of MMP‐13 by Condylar Temporomandibular Joint Cells

Frequency and Morbidity of Temporomandibular Joint Involvement in Adult Patients With a History of Juvenile Idiopathic Arthritis

TMD and pregnancy?

Contact Info

Product

Resources

About