Ten‐m/Odz3 regulates migration and differentiation of chondrogenic ATDC5 cells via RhoA‐mediated actin reorganization

Takano, Ikuko; Takeshita, Nobuo; Yoshida, Michiko; Seki, Daisuke; Oyanagi, Toshihito; Kimura, Seiji; Jiang, Wei; Sasaki, Kaoru; Sogi, Chisumi; Kawatsu, Masayoshi; Takano‐Yamamoto, Teruko

doi:10.1002/jcp.30058

Cited by 6 publications

(2 citation statements)

References 43 publications

(66 reference statements)

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“…PE is a semicrystalline material, consisting of both crystalline and amorphous regions. The ratio between these regions has an impact on blooming, although the associated molecular mechanisms are still being debated. − Post-manufacturing processing can also have a significant influence on the diffusivity of blooming molecules and blooming rates through the reorganization of crystalline and amorphous domains . When stretched at room temperature, a procedure known as cold drawing, PE “necks” and spherulitic regions begin to reorient .…”

Section: Resultsmentioning

confidence: 99%

ROY Crystallization on Poly(ethylene) Fibers, a Model for Bed Net Crystallography

Erriah,

Shtukenberg,

Aronin

et al. 2024

Chem. Mater.

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Many long-lasting insecticidal bed nets for protection against disease vectors consist of poly(ethylene) fibers in which insecticide is incorporated during manufacture. Insecticide molecules diffuse from within the supersaturated polymers to surfaces where they become bioavailable to insects and often crystallize, a process known as blooming. Recent studies revealed that contact insecticides can be highly polymorphic. Moreover, insecticidal activity is polymorph-dependent, with forms having a higher crystal free energy yielding faster insect knockdown and mortality. Consequently, the crystallographic characterization of insecticide crystals that form on fibers is critical to understanding net function and improving net performance. Structural characterization of insecticide crystals on bed net fiber surfaces, let alone their polymorphs, has been elusive owing to the minute size of the crystals, however. Using the highly polymorphous compound ROY (5-methyl-2-[(2nitrophenyl)-amino]thiophene-3-carbonitrile) as a proxy for insecticide crystallization, we investigated blooming and crystal formation on the surface of extruded poly(ethylene) fibers containing ROY. The blooming rates, tracked from the time of extrusion, were determined by UV−vis spectroscopy after successive washes. Six crystalline polymorphs (of the 13 known) were observed on poly(ethylene) fiber surfaces, and they were identified and characterized by Raman microscopy, scanning electron microscopy, and 3D electron diffraction. These observations reveal that the crystallization and phase behavior of polymorphs forming on poly(ethylene) fibers is complex and dynamic. The characterization of blooming and microcrystals underscores the importance of bed net crystallography for the optimization of bed net performance.

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Section: Resultsmentioning

confidence: 99%

ROY Crystallization on Poly(ethylene) Fibers, a Model for Bed Net Crystallography

Erriah,

Shtukenberg,

Aronin

et al. 2024

Chem. Mater.

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“…Teneurin transmembrane protein 3 (TENM3) encodes a large transmembrane protein involved in neural development by regulating the establishment of proper connectivity within the nervous system (1)(2)(3). It has been found to play a role in the development of the human eye by regulating the formation of ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus and the superior colliculus (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Case report: Expansion of phenotypic and genotypic data in TENM3-related syndrome: Report of two cases

Zheng

et al. 2023

Front. Pediatr.

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Biallelic TENM3 variants were recently reported to cause non-syndromic microphthalmia with coloboma-9 (MCOPCB9) and microphthalmia and/or coloboma with developmental delay (MCOPS15). To date, only eight syndromic and non-syndromic microphthalmia cases with recessive TENM3 variants have been reported. Herein, we report two unrelated new cases with biallelic variants in TENM3, widening the molecular and clinical spectrum. Regarding patient 1, WES revealed compound heterozygous variants in the TENM3 gene: c.3847_3855del; p.Leu1283_Ser1285del and c.3698_3699insA; p.Thr1233Thrfs*20 in the index patient, who was presenting with bilateral microphthalmia, congenital cataract, microcephaly, and global developmental delay. Regarding patient 2, compound missense heterozygous variants in the TENM3 gene were identified: c.941C > T; p.Ala314Val and c.6464T > C; p.Leu2155Pro in the 3-year-old boy, who presented with congenital esotropia, speech delay, and motor developmental delay. The clinical features of these two cases revealed high concordance with the previously reported cases, including microphthalmia and developmental delay. The presence of microcephaly in our patient potentially expands the neurologic phenotype associated with loss of function variants in TENM3, as microcephaly has not previously been described. Furthermore, we present evidence that missense variants in TENM3 are associated with similar, but milder, ocular features.

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RHOA inhibits chondrogenic differentiation of mesenchymal stem cells in adolescent idiopathic scoliosis

Yang

Chen

Hou

et al. 2022

Connective Tissue Research

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Ten‐m/Odz3 regulates migration and differentiation of chondrogenic ATDC5 cells via RhoA‐mediated actin reorganization

Cited by 6 publications

References 43 publications

ROY Crystallization on Poly(ethylene) Fibers, a Model for Bed Net Crystallography

ROY Crystallization on Poly(ethylene) Fibers, a Model for Bed Net Crystallography

Case report: Expansion of phenotypic and genotypic data in TENM3-related syndrome: Report of two cases

RHOA inhibits chondrogenic differentiation of mesenchymal stem cells in adolescent idiopathic scoliosis

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